2008
CLINICAL STUDY: Subjective responses and cardiovascular effects of self‐administered cocaine in cocaine‐abusing men and women
Lynch WJ, Kalayasiri R, Sughondhabirom A, Pittman B, Coric V, Morgan PT, Malison RT. CLINICAL STUDY: Subjective responses and cardiovascular effects of self‐administered cocaine in cocaine‐abusing men and women. Addiction Biology 2008, 13: 403-410. PMID: 18782384, PMCID: PMC3690939, DOI: 10.1111/j.1369-1600.2008.00115.x.Peer-Reviewed Original ResearchConceptsSelf-administer cocaineSelf-administered cocaine infusionsDiastolic blood pressureSubjective effect measuresCocaine-induced increasesCocaine self-administration sessionsFeelings of hungerFixed ratio 1Cocaine-abusing menSelf-administration sessionsTime-dependent increaseCardiovascular effectsBlood pressureCardiovascular responsesHormonal influencesCocaine abuseSecondary analysisCocaine infusionsHuman laboratoryCardiovascular measuresEffect measuresWomenCocaineMenSignificant main effect
2006
A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial
Lynch WJ, Sughondhabirom A, Pittman B, Gueorguieva R, Kalayasiri R, Joshua D, Morgan P, Coric V, Malison RT. A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial. Psychopharmacology 2006, 185: 306-314. PMID: 16521032, DOI: 10.1007/s00213-006-0323-5.Peer-Reviewed Original ResearchConceptsTest-retest reliabilityCocaine administrationSelf-administered cocaine infusionsCocaine intakeTest-retest componentRegulation of cocaineTiming of infusionAbuse/dependenceDose-dependent fashionFixed ratio 1Non-treatment seeking volunteersDose-dependent wayCocaine abuse/dependenceCurrent studyHuman laboratory modelDrug-induced euphoriaCocaine-taking behaviorHuman cocaine usersCardiovascular responsesHuman laboratory paradigmCocaine infusionsConsecutive daysSubjective effectsPilot studyCocaine users