2013
The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type
Fox HC, Sofuoglu M, Morgan PT, Tuit KL, Sinha R. The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type. Psychoneuroendocrinology 2013, 38: 1532-1544. PMID: 23374328, PMCID: PMC3772967, DOI: 10.1016/j.psyneuen.2012.12.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultAffectAlcohol DrinkingAnxietyArousalBlood PressureCocaine-Related DisordersComorbidityCuesDepressionDouble-Blind MethodEmotionsEstradiolFemaleHeart RateHumansHydrocortisoneHypothalamo-Hypophyseal SystemImagery, PsychotherapyMaleMiddle AgedPituitary-Adrenal SystemProgesteroneRelaxation TherapySex CharacteristicsSmokingStress, PsychologicalStroop TestConceptsDrug cravingCocaine-dependent menCognitive performanceStress arousalTreatment-seeking cocaine dependent individualsCue-induced cravingCocaine-dependent individualsCue typesStroop performanceSubjective cravingCognitive measuresImagery conditionNegative emotionsCue exposureInhibitory controlRelaxed moodDependent individualsDependent menArousal stateCravingArousalCounterbalanced orderStress exposureRewarding effectsCocaine dependence
2010
Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14455-14459. PMID: 20660731, PMCID: PMC2922598, DOI: 10.1073/pnas.1002467107.Peer-Reviewed Original ResearchConceptsMiddle frontal cortexStop-signal reaction timeCocaine-dependent patientsWhole-brain linear regressionLonger stop-signal reaction timesFunctional MRI studyInhibitory controlInhibition-related activationBlood pressureIntravenous methylphenidatePeripheral biomarkersSignal reaction timeFrontal cortexStop-signal taskIndividualized treatmentHealthy individualsMRI studiesVentromedial prefrontal cortexSpecific neural mechanismsCocaine dependenceBiological markersPrefrontal cortexPatientsMethylphenidate responseSignal task