2014
Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals
Fox HC, Morgan PT, Sinha R. Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals. Neuropsychopharmacology 2014, 39: 1527-1537. PMID: 24395021, PMCID: PMC3988558, DOI: 10.1038/npp.2014.1.Peer-Reviewed Original ResearchConceptsCocaine use disorderImagery conditionNegative emotionsDrug cravingUse disordersCocaine-dependent individualsCocaine-dependent malesCocaine-dependent menSex differencesGuanfacine's effectsDrug cuesImagery exposureNegative moodSystolic blood pressureStress arousalNicotine cravingAlcohol cravingCounterbalanced orderCravingCocaine cravingAnxietyCocaine addictionEmotionsRecovery time pointsGuanfacine
2011
Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings
Fox HC, Anderson GM, Tuit K, Hansen J, Kimmerling A, Siedlarz KM, Morgan PT, Sinha R. Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings. Alcohol Clinical And Experimental Research 2011, 36: 351-360. PMID: 21919922, PMCID: PMC3243763, DOI: 10.1111/j.1530-0277.2011.01628.x.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcoholismAnxietyBlood PressureCuesDiagnostic and Statistical Manual of Mental DisordersDouble-Blind MethodEmotionsFemaleHemodynamicsHumansHypothalamo-Hypophyseal SystemImaginationMalePituitary-Adrenal SystemPrazosinSecondary PreventionStress, PsychologicalConceptsCue-induced alcohol cravingNegative emotionsAlcohol-dependent individualsBlunted HPA responseAlcohol cravingAlcohol cuesStress dysregulationTreatment-seeking alcohol-dependent individualsCue-induced alcoholAlcohol cue exposureCue-Induced CravingImagery exposureBlood pressureHPA responseLower alcohol cravingCue exposureRelapse susceptibilityPreliminary efficacy studyEmotionsPrazosin groupPlacebo groupCravingCounterbalanced orderControl conditionAnxiety