1992
Characterization of a direct effect of phorbol myristate acetate on human neutrophil cell membrane using 31D8 monoclonal antibody
Woronick C, Maderazo E, Anthony M, Krause P, Sha'afi R. Characterization of a direct effect of phorbol myristate acetate on human neutrophil cell membrane using 31D8 monoclonal antibody. Journal Of Leukocyte Biology 1992, 51: 289-295. PMID: 1541911, DOI: 10.1002/jlb.51.3.289.Peer-Reviewed Original ResearchConceptsPolymorphonuclear neutrophilsAntigen expressionLate effectsAlpha-tocopherolProtein kinase CInhibitor of cyclooxygenaseNormal polymorphonuclear neutrophilsKinase CPhorbol myristate acetateNeutrophil cell membraneProtective effectConcentrations of PMADirect effectHuman neutrophilsMonoclonal antibodiesMyristate acetateInhibitory affectRapid initiationMembrane stabilizationBetamethasoneNeutrophilsOxidative burstInactive analoguePMAPMA effect
1991
Modulation of Neonatal Neutrophil Function by Pentoxifylline
Krause P, Maderazo E, Contrino J, Eisenfeld L, Herson V, Greca N, Bannon P, Kreutzer D. Modulation of Neonatal Neutrophil Function by Pentoxifylline. Pediatric Research 1991, 29: 123-127. PMID: 2014147, DOI: 10.1203/00006450-199102000-00002.Peer-Reviewed Original ResearchConceptsPMN functionNitroblue tetrazolium reductionImpaired PMN functionsNeonatal neutrophil functionTetrazolium reductionTreatment of infectionsPolymorphonuclear leukocyte chemotaxisF-actin contentDose-dependent effectPotential clinical useCertain disease processesSimilar dose-dependent responseDose-dependent responseNeutrophil functionNewborn infantsPMN activityPMN deformabilityPMN chemotaxisDisease processPentoxifyllineLeukocyte chemotaxisMethylxanthine pentoxifyllinePhagocytic activityNeonatesClinical use
1990
Longitudinal study of neutrophil adherence and motility
Eisenfeld L, Krause P, Herson V, Savidakis J, Bannon P, Maderazo E, Woronick C, Giuliano C, Banco L. Longitudinal study of neutrophil adherence and motility. The Journal Of Pediatrics 1990, 117: 926-929. PMID: 2246695, DOI: 10.1016/s0022-3476(05)80139-8.Peer-Reviewed Original ResearchThe role of cellular maturation in neutrophil heterogeneity.
Krause P, Todd M, Hancock W, Pastuszak W, Maderazo E, Hild D, Kosciol C. The role of cellular maturation in neutrophil heterogeneity. Blood 1990, 76: 1639-46. PMID: 2207334, DOI: 10.1182/blood.v76.8.1639.bloodjournal7681639.Peer-Reviewed Original ResearchConceptsMaturational differencesPositive bone marrow cellsPeripheral blood PMNFunctional heterogeneityBone marrow cellsFlow cytometric analysisDifferent functional capacitiesBlood PMNMonoclonal antibody labelingNeutrophil heterogeneityPMN subpopulationFunctional capacityAntigenic expressionMyeloid cellsNeutrophil characteristicsFunctional maturationPMN populationCytometric analysisMorphologic maturationMarrow cellsMyeloblast cellsHL-60 cellsAntigenPMNHeterogeneous expression
1989
Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function
Herson V, Block C, Eisenfeld L, Maderazo E, Krause P. Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function. Journal Of Parenteral And Enteral Nutrition 1989, 13: 620-622. PMID: 2515309, DOI: 10.1177/0148607189013006620.Peer-Reviewed Original ResearchConceptsPolymorphonuclear leukocytesIntralipid infusionNeonatal intensive care unitAdult polymorphonuclear leukocytesIntensive care unitIntravenous fat infusionPresence of infectionAdverse hematologic effectsNeonatal polymorphonuclear leukocytesParenteral nutritionIll neonatesNeonatal neutrophilsPMN countCare unitPlatelet countPlatelet activityHematologic effectsIntravenous fatPlatelet functionPlatelet numberUnchanged preFat infusionPlatelet aggregationInfusionIntralipidEnhancement of neutrophil function for treatment of neonatal infections
KRAUSE P, HERSON V, EISENFELD L, JOHNSON G. Enhancement of neutrophil function for treatment of neonatal infections. The Pediatric Infectious Disease Journal 1989, 8: 382-389. PMID: 2664694, DOI: 10.1097/00006454-198906000-00011.Peer-Reviewed Original ResearchConceptsNewborn infantsRisk of morbidityFresh frozen plasmaMaximum therapeutic benefitHost defense mechanismsNeonatal infectionImportant therapyNeutrophil functionFrozen plasmaPMN functionTherapeutic benefitAdult PMNInfectionFurther studiesInfantsNew antibioticsDefense mechanismsTransfusionMorbidityNeonatesTherapyMortalityAdministrationImpairmentAntibodiesCharacterization of Nonmotile Neutrophil Subpopulations in Neonates and Adults
Krause P, Kreutzer D, Eisenfeld L, Herson V, Weisman S, Bannon P, Greca N. Characterization of Nonmotile Neutrophil Subpopulations in Neonates and Adults. Pediatric Research 1989, 25: 519-524. PMID: 2717268, DOI: 10.1203/00006450-198905000-00019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, MonoclonalChemotaxis, LeukocyteFetal BloodHumansInfant, NewbornNeutrophilsPhagocytosisConceptsPMN subpopulationPolymorphonuclear leukocytesPMN motilityAdult polymorphonuclear leukocytesMost polymorphonuclear leukocytesMicropore filtersNeutrophil subpopulationsHomogeneous populationPhagocytic functionNeonatesChemotactic stimuliMAbsSubpopulationsAdultsPMN precursorsPresent studyHigh percentageMotilityCellsPrevious studiesPopulationLeukocytesAntibodies
1987
Host defense during pregnancy: Neutrophil chemotaxis and adherence
Krause P, Ingardia C, Pontius L, Malech H, LoBello T, Maderazo E. Host defense during pregnancy: Neutrophil chemotaxis and adherence. American Journal Of Obstetrics And Gynecology 1987, 157: 274-280. PMID: 3618673, DOI: 10.1016/s0002-9378(87)80150-3.Peer-Reviewed Original ResearchMeSH KeywordsCell AdhesionChemotaxis, LeukocyteFemaleHumansLabor, ObstetricNeutrophilsPostpartum PeriodPregnancyConceptsPolymorphonuclear leukocyte chemotaxisPregnant womenLeukocyte chemotaxisThird trimesterLeukocyte adherenceNonpregnant control subjectsIncidence of infectionMonths post partumPolymorphonuclear leukocyte adherenceNylon wool columnsMicropore filter assaysHumoral defectsFirst trimesterAutoimmune diseasesControl subjectsImmunologic functionPostpartum periodNeutrophil chemotaxisPregnancyWool columnsHost defensePost partumTrimesterNeutrophil motilityWomenThe Effect of Betamethasone on Neonatal Neutrophil Chemotaxis
Fuenfer M, Herson V, Raye J, Woronick C, Eisenfeld L, Ingardia C, Block C, Krause P. The Effect of Betamethasone on Neonatal Neutrophil Chemotaxis. Pediatric Research 1987, 22: 150-153. PMID: 3658539, DOI: 10.1203/00006450-198708000-00009.Peer-Reviewed Original ResearchConceptsEffect of betamethasoneBacterial infectionsNewborn infantsPMN functionMaternal glucocorticoid administrationNeonatal PMN functionFetal lung maturationMigration of PMNRandom migrationConcentrations of betamethasonePMN random migrationSignificant clinical importanceBetamethasone administrationGlucocorticoid administrationPregnant womenLung maturationNeutrophil functionStandard doseCord bloodNeutrophil chemotaxisAntiinflammatory agentsClinical importanceImportant causeImmune systemBetamethasone
1986
Polymorphonuclear Leukocyte Adherence and Chemotaxis in Stressed and Healthy Neonates
Krause P, Herson V, Boutin-Lebowitz J, Eisenfeld L, Block C, LoBello T, Maderazo E. Polymorphonuclear Leukocyte Adherence and Chemotaxis in Stressed and Healthy Neonates. Pediatric Research 1986, 20: 296-300. PMID: 3703618, DOI: 10.1203/00006450-198604000-00004.Peer-Reviewed Original ResearchConceptsStressed neonatesHealthy neonatesPMN adherencePMN chemotaxisAcute lower respiratory illnessBacterial infectionsPolymorphonuclear neutrophil (PMN) adherenceLower respiratory illnessPolymorphonuclear leukocyte adherenceRespiratory illnessNeutrophil adherenceLeukocyte adherenceFurther impairmentNeonatesHealthy adultsImportant causeGreater riskInfectionChemotaxis assaysAdherenceAdultsIllnessChemotaxisSignificant improvementSusceptibility
1982
Abnormalities of neutrophil adherence in newborns.
Krause P, Maderazo E, Scroggs M. Abnormalities of neutrophil adherence in newborns. Pediatrics 1982, 69: 184-7. PMID: 7058092, DOI: 10.1542/peds.69.2.184.Peer-Reviewed Original ResearchConceptsPMN adherenceNeutrophil adherencePolymorphonuclear neutrophil (PMN) adherenceHealthy term newbornsSerious bacterial infectionsSusceptibility of neonatesTerm newbornsNeonatal PMNNeonatal serumNylon woolAdult serumHumoral inhibitorAdult PMNBacterial infectionsGlass adherenceNormal childrenGood healthAdherenceGreater reductionPMNNewbornsSerumCellular defectsAdultsChildren