2010
Hypersensitivity to Thromboxane Receptor Mediated Cerebral Vasomotion and CBF Oscillations during Acute NO-Deficiency in Rats
Horváth B, Lenzsér G, Benyó B, Németh T, Benkő R, Iring A, Hermán P, Komjáti K, Lacza Z, Sándor P, Benyó Z. Hypersensitivity to Thromboxane Receptor Mediated Cerebral Vasomotion and CBF Oscillations during Acute NO-Deficiency in Rats. PLOS ONE 2010, 5: e14477. PMID: 21217826, PMCID: PMC3013104, DOI: 10.1371/journal.pone.0014477.Peer-Reviewed Original ResearchMeSH Keywords15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsBrainCerebrovascular CirculationEnzyme InhibitorsHypersensitivityLaser-Doppler FlowmetryMaleMiddle Cerebral ArteryMotionNG-Nitroarginine Methyl EsterNitric OxideRatsRats, WistarReceptors, ThromboxaneRho-Associated KinasesSignal TransductionThromboxane A2ConceptsCerebral blood flowCBF oscillationsNitric oxideCerebral vasomotionThromboxane receptorNitro-L-arginine methyl esterDecreased cerebral blood flowMean arterial blood pressureEndothelium-derived nitric oxideTP receptor agonist UAbsence of NOCerebral circulatory parametersLow-frequency spontaneous fluctuationsArterial blood pressureTP receptor activationCerebrovascular toneEndothelial dysfunctionBlood pressureL-NAMEVascular effectsAgonist UNO deficiencyCirculatory parametersPharmacological modulationBlood flow
2007
Influence of the heme-oxygenase pathway on cerebrocortical blood flow
Leszl-Ishiguro M, Horváth B, Johnson R, Johnson F, Lenzsér G, Hermán P, Horváth E, Benyó Z. Influence of the heme-oxygenase pathway on cerebrocortical blood flow. Neuroreport 2007, 18: 1193-1197. PMID: 17589325, DOI: 10.1097/wnr.0b013e3282202459.Peer-Reviewed Original ResearchConceptsCerebrocortical blood flowNitric oxide synthaseEndogenous carbon monoxideBlood flowInhibition of NOSDirect vascular effectsHeme oxygenase pathwayCentral nervous systemNOS blockadeVascular effectsCBF responseOxide synthaseAdult ratsNervous systemHeme oxygenaseBlockadeRatsCurrent studyInhibitionHypercapniaLatter effectHypoxia