2001
Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers
Sant'Angelo D, Cresswell P, Janeway C, Denzin L. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6824-6829. PMID: 11381132, PMCID: PMC34437, DOI: 10.1073/pnas.121179998.Peer-Reviewed Original ResearchConceptsAllelic exclusionTCR heterodimerTCR proteinsCell surface expressionTCR lociT cellsCell surfaceFurther recombinationProteinAlpha chainBeta chainHeterodimersSurface expressionTransgenic miceTCR transgenic miceCellsAdditional mechanismExpressionTCR clonalityAssembly processGenesSecond TCRLociRNATCRA Role for Calnexin in the Assembly of the MHC Class I Loading Complex in the Endoplasmic Reticulum
Diedrich G, Bangia N, Pan M, Cresswell P. A Role for Calnexin in the Assembly of the MHC Class I Loading Complex in the Endoplasmic Reticulum. The Journal Of Immunology 2001, 166: 1703-1709. PMID: 11160214, DOI: 10.4049/jimmunol.166.3.1703.Peer-Reviewed Original ResearchAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP-Binding Cassette TransportersCalcium-Binding ProteinsCalnexinCalreticulinCell Line, TransformedDimerizationEndoplasmic ReticulumHeat-Shock ProteinsHeLa CellsHistocompatibility Antigens Class IHLA AntigensHumansImmunoglobulinsIsomerasesKineticsMajor Histocompatibility ComplexMembrane Transport ProteinsProtein BindingProtein Disulfide-IsomerasesRibonucleoproteinsTumor Cells, Cultured
1999
The nature of the MHC class I peptide loading complex
Cresswell P, Bangia N, Dick T, Diedrich G. The nature of the MHC class I peptide loading complex. Immunological Reviews 1999, 172: 21-28. PMID: 10631934, DOI: 10.1111/j.1600-065x.1999.tb01353.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationATP Binding Cassette Transporter, Subfamily B, Member 2ATP Binding Cassette Transporter, Subfamily B, Member 3ATP-Binding Cassette TransportersDimerizationEndoplasmic ReticulumHistocompatibility Antigens Class IHumansModels, MolecularPeptidesProtein BindingProtein Structure, Quaternary
1998
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
Pamer E, Cresswell P. MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING. Annual Review Of Immunology 1998, 16: 323-358. PMID: 9597133, DOI: 10.1146/annurev.immunol.16.1.323.Peer-Reviewed Original Research
1997
Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin
Grandea III A, Lehner PJ, Cresswell P, Spies T. Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin. Immunogenetics 1997, 46: 477-483. PMID: 9321427, DOI: 10.1007/s002510050308.Peer-Reviewed Original ResearchA Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes
Ortmann B, Copeman J, Lehner P, Sadasivan B, Herberg J, Grandea A, Riddell S, Tampé R, Spies T, Trowsdale J, Cresswell P. A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes. Science 1997, 277: 1306-1309. PMID: 9271576, DOI: 10.1126/science.277.5330.1306.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigen PresentationAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP Binding Cassette Transporter, Subfamily B, Member 3ATP-Binding Cassette TransportersCalcium-Binding ProteinsCalreticulinCell LineCell Line, TransformedChromosome MappingChromosomes, Human, Pair 6Cloning, MolecularDimerizationEndoplasmic ReticulumGenetic LinkageHistocompatibility Antigens Class IHLA AntigensHumansImmunoglobulin GImmunoglobulinsMajor Histocompatibility ComplexMembrane Transport ProteinsMolecular Sequence DataRibonucleoproteinsSequence Homology, Amino AcidT-Lymphocytes, CytotoxicTumor Cells, Cultured
1996
HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules
Denzin L, Hammond C, Cresswell P. HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules. Journal Of Experimental Medicine 1996, 184: 2153-2166. PMID: 8976171, PMCID: PMC2196380, DOI: 10.1084/jem.184.6.2153.Peer-Reviewed Original ResearchConceptsClass II moleculesHLA-DR moleculesHLA-DMDR moleculesMajor histocompatibility complex classAntigenic peptidesEmpty class II moleculesCLIP dissociationHistocompatibility complex classMHC class II compartmentsHLA-DM moleculesClass II compartmentsII-CLIP complexesClass II dimersAlpha beta dimersAntigen processingBeta dimersDR complexesCell linesInvariant chain fragmentComplex classAssociationLow levels