2001
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus
Chin K, Cresswell P. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 15125-15130. PMID: 11752458, PMCID: PMC64994, DOI: 10.1073/pnas.011593298.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCells, CulturedCytomegalovirusDNA, ComplementaryHumansInterferon-alphaInterferon-betaMolecular Sequence DataOxidoreductases Acting on CH-CH Group DonorsProtein BiosynthesisProteinsSequence Homology, Amino AcidViral Envelope ProteinsVirus ReplicationGlycosylation and the Immune System
Rudd P, Elliott T, Cresswell P, Wilson I, Dwek R. Glycosylation and the Immune System. Science 2001, 291: 2370-2376. PMID: 11269318, DOI: 10.1126/science.291.5512.2370.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigen-Antibody ReactionsAntigen-Presenting CellsAntigens, CD1Carrier ProteinsCollectinsComplement System ProteinsEndoplasmic ReticulumEpitopesGlycoproteinsGlycosylationHistocompatibility AntigensHumansImmune SystemImmunoglobulinsPolysaccharidesProtein FoldingT-LymphocytesViral Envelope ProteinsConceptsImmune systemMajor histocompatibility complex antigensAntigen-presenting cellsAdaptive immune responsesCellular immune systemHistocompatibility complex antigensHumoral immune systemT cell receptor complexRheumatoid arthritisMannose-binding lectinAutoimmune diseasesCell receptor complexT cellsImmune responseComplex antigensPeptide antigensComplement componentsImmunoglobulin GAntigenKey moleculesReceptor complexSpecific glycoformsGlycoproteinGlycopeptide antigensArthritis
1999
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells
Tomazin R, Boname J, Hegde N, Lewinsohn D, Altschuler Y, Jones T, Cresswell P, Nelson J, Riddell S, Johnson D. Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nature Medicine 1999, 5: 1039-1043. PMID: 10470081, DOI: 10.1038/12478.Peer-Reviewed Original ResearchConceptsHuman cytomegalovirusT cellsT lymphocytesClass II proteinsMHC class II antigen presentation pathwayMHC class II pathwayClass II antigen presentation pathwayHCMV-infected macrophagesAntigen presentation pathwayClass II pathwayLifelong latent infectionLife-threatening diseaseMonocytes/macrophagesMHC class IImportant host cellsMHC class II proteinsImmune evasion proteinsVirus reactivationHLA-DRLatent reservoirPresent antigensGlial cellsUbiquitous herpesvirusLatent infectionPresentation pathway
1997
The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation
Lehner P, Karttunen J, Wilkinson G, Cresswell P. The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6904-6909. PMID: 9192664, PMCID: PMC21257, DOI: 10.1073/pnas.94.13.6904.Peer-Reviewed Original Research