2024
mosGILT controls innate immunity and germ cell development in Anopheles gambiae
Arora G, Tang X, Cui Y, Yang J, Chuang Y, Joshi J, Sajid A, Dong Y, Cresswell P, Dimopoulos G, Fikrig E. mosGILT controls innate immunity and germ cell development in Anopheles gambiae. BMC Genomics 2024, 25: 42. PMID: 38191283, PMCID: PMC10775533, DOI: 10.1186/s12864-023-09887-0.Peer-Reviewed Original ResearchConceptsGerm cell developmentAnopheles gambiaeCell developmentOvarian developmentReductase-like proteinWild-type mosquitoesPlasmodium life cycleBiological controlGrowth genesEssential regulatorRNA sequencingA. gambiaeGenesGambiaeAltered expressionImpaired ovarian developmentMosquito vectorsLife cycleMosquitoesImmune activationPlasmodium infectionTranscriptomeOogenesisRegulatorProtein
2001
Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers
Sant'Angelo D, Cresswell P, Janeway C, Denzin L. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6824-6829. PMID: 11381132, PMCID: PMC34437, DOI: 10.1073/pnas.121179998.Peer-Reviewed Original ResearchConceptsAllelic exclusionTCR heterodimerTCR proteinsCell surface expressionTCR lociT cellsCell surfaceFurther recombinationProteinAlpha chainBeta chainHeterodimersSurface expressionTransgenic miceTCR transgenic miceCellsAdditional mechanismExpressionTCR clonalityAssembly processGenesSecond TCRLociRNATCR
1998
Elucidation of the genetic basis of the antigen presentation defects in the mutant cell line .220 reveals polymorphism and alternative splicing of the tapasin gene
Copeman J, Bangia N, Cross J, Cresswell P. Elucidation of the genetic basis of the antigen presentation defects in the mutant cell line .220 reveals polymorphism and alternative splicing of the tapasin gene. European Journal Of Immunology 1998, 28: 3783-3791. PMID: 9842921, DOI: 10.1002/(sici)1521-4141(199811)28:11<3783::aid-immu3783>3.0.co;2-9.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAntigen PresentationAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP-Binding Cassette TransportersB-LymphocytesCell LineDNA, ComplementaryEndoplasmic ReticulumExonsHumansImmunoglobulinsMembrane Transport ProteinsMutationPolymorphism, GeneticReverse Transcriptase Polymerase Chain ReactionConceptsMutant cell linesEndoplasmic reticulumAlternative splicingN-terminal 49 amino acidsGenetic basisTapasin geneExon twoWild-type cellsFull-length transcriptsCell linesSingle nucleotide substitutionSignal peptideSecond intronNucleotide substitutionsPhysical associationSplice siteGlycoprotein tapasinPosition 240Amino acidsClass I moleculesSplicingOptimal bindingGenesI moleculesHeterodimersGenomic analysis of the Tapasin gene, located close to the TAP loci in the MHC
Herberg J, Sgouros J, Jones T, Copeman J, Humphray S, Sheer D, Cresswell P, Beck S, Trowsdale J. Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. European Journal Of Immunology 1998, 28: 459-467. PMID: 9521053, DOI: 10.1002/(sici)1521-4141(199802)28:02<459::aid-immu459>3.0.co;2-z.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP-Binding Cassette TransportersBase SequenceCentromereExonsGenes, MHC Class IHistocompatibility Antigens Class IHumansImmunoglobulinsIntronsMembrane Transport ProteinsMiceMolecular Sequence DataPhylogenyRatsConceptsTapasin geneMouse ESTsSyntenic positionsGenomic analysisSeparate exonsGene sequencesDistinct phylogenyEndoplasmic reticulumGenesK locusChromosome 17IgC domainFunctional significanceLociMHC class IClass IHLA-DP locusTAP2 genesEquivalent locationsTAP transporterTapasin moleculePhylogenyIntronsChromosomesESTs
1987
Regulation of HLA Class I and Class II antigen expression
Cresswell P. Regulation of HLA Class I and Class II antigen expression. British Medical Bulletin 1987, 43: 66-80. PMID: 3315102, DOI: 10.1093/oxfordjournals.bmb.a072177.Peer-Reviewed Original ResearchConceptsCell surfaceRegulatory genesTranscriptional levelHybridisation experimentsIntracellular transportThird glycoproteinHeterodimeric glycoproteinCell typesChondroitin sulfate proteoglycanEfficient assemblyCell linesSulfate proteoglycanEnhanced expressionT cell linesGenesClass IExpressionTissue distributionRegulationLymphoblastoid linesGlycoproteinUnusual complexityClass I moleculesInvariant chainBiosynthesis
1985
Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression
Carrington M, Salter R, Cresswell P, Ting J. Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression. Immunogenetics 1985, 22: 219-229. PMID: 2995246, DOI: 10.1007/bf00404481.Peer-Reviewed Original ResearchConceptsGene expressionDNA methylationLymphoblastoid cell linesRegulatory mechanismsDNA hypomethylationParental linesHybrid linesSomatic cell hybridsRestriction enzyme Hpa IIHpa II digestionMsp I siteDifferent regulatory mechanismsCell hybridsGenomic probesGene inductionUnexpressed genesComplete demethylationHpa IIGenesDR genesMethylationT-LCLCell linesI siteHypomethylation