2010
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice
Leviel F, Hübner CA, Houillier P, Morla L, Moghrabi S, Brideau G, Hatim H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D. The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. Journal Of Clinical Investigation 2010, 120: 1627-1635. PMID: 20389022, PMCID: PMC2860930, DOI: 10.1172/jci40145.Peer-Reviewed Original ResearchConceptsNa-Cl cotransporterSodium transportMaintenance of euvolemiaTransepithelial NaCl absorptionDucts of miceEpithelial sodium channelIntravascular volumeIndependent Cl-/HCO3Sodium balanceMouse CCDAmiloride-sensitive epithelial sodium channelSodium absorptionExcretion resultsFluid homeostasisGenetic ablationNaCl absorptionSodium channelsMiceCl-/HCO3NaCl transportSlc4a8Genetic disruptionNovel roleHydrochlorothiazideDuct
2002
Ion exchangers mediating NaCl transport in the renal proximal tubule
Aronson PS. Ion exchangers mediating NaCl transport in the renal proximal tubule. Cell Biochemistry And Biophysics 2002, 36: 147-153. PMID: 12139400, DOI: 10.1385/cbb:36:2-3:147.Commentaries, Editorials and LettersConceptsProximal tubulesNaCl absorptionOxalate-sulfate exchangeLoop of HenleProximal tubule cellsNaCl transportRenal proximal tubulesRecycling of formateRole of NHE3NHE3 null miceTubule cellsNull micePerfusion solutionNephron segmentsIsoform-specific antibodiesApical membraneRenal brush border vesiclesMammalian proximal tubuleBrush border vesiclesSulfate cotransportBrush border membrane vesiclesTubulesFormate exchangeNHE3Stimulation
2001
Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron
Wang T, Hropot M, Aronson P, Giebisch G. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. American Journal Of Physiology. Renal Physiology 2001, 281: f1117-f1122. PMID: 11704563, DOI: 10.1152/ajprenal.2001.281.6.f1117.Peer-Reviewed Original ResearchConceptsLoop of HenleHOE 694Proximal tubulesAddition of ethylisopropylamilorideDistal convoluted tubuleBicarbonate reabsorptionConvoluted tubulesSitu microperfusionRat kidneySignificant inhibitionNHE isoformsHenlePredominant isoformTubulesNHE3Functional roleInhibitionNHE2Apical membraneIsoformsApical isoformKidneyMicroperfusionEthylisopropylamilorideNephron
1999
Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice
Wang T, Yang C, Abbiati T, Schultheis P, Shull G, Giebisch G, Aronson P. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice. American Journal Of Physiology 1999, 277: f298-f302. PMID: 10444585, DOI: 10.1152/ajprenal.1999.277.2.f298.Peer-Reviewed Original Research
1996
Mechanisms of stimulation of proximal tubule chloride transport by formate and oxalate
Wang T, Egbert AL, Abbiati T, Aronson PS, Giebisch G. Mechanisms of stimulation of proximal tubule chloride transport by formate and oxalate. American Journal Of Physiology 1996, 271: f446-f450. PMID: 8770178, DOI: 10.1152/ajprenal.1996.271.2.f446.Peer-Reviewed Original Research
1993
Effects of formate and oxalate on chloride absorption in rat distal tubule
Wang T, Agulian SK, Giebisch G, Aronson PS. Effects of formate and oxalate on chloride absorption in rat distal tubule. American Journal Of Physiology 1993, 264: f730-f736. PMID: 8386473, DOI: 10.1152/ajprenal.1993.264.4.f730.Peer-Reviewed Original Research
1992
Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogs
Zweifach A, Desir G, Aronson P, Giebisch G. Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogs. The Journal Of Membrane Biology 1992, 128: 115-122. PMID: 1501239, DOI: 10.1007/bf00231884.Peer-Reviewed Original Research
1991
Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles
Soleimani M, Lesoine GA, Bergman JA, Aronson PS. Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles. Journal Of Biological Chemistry 1991, 266: 8706-8710. PMID: 2026588, DOI: 10.1016/s0021-9258(18)31503-5.Peer-Reviewed Original ResearchIncreased Na(+)-H+ antiporter activity in apical membrane vesicles from mutant LLC-PK1 cells
Reilly RF, Haggerty JG, Aronson PS, Adelberg EA, Slayman CW. Increased Na(+)-H+ antiporter activity in apical membrane vesicles from mutant LLC-PK1 cells. American Journal Of Physiology 1991, 260: c738-c744. PMID: 1673319, DOI: 10.1152/ajpcell.1991.260.4.c738.Peer-Reviewed Original ResearchHigh affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles
Desir GV, Cragoe EJ, Aronson PS. High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles. Journal Of Biological Chemistry 1991, 266: 2267-2271. PMID: 1846621, DOI: 10.1016/s0021-9258(18)52238-9.Peer-Reviewed Original ResearchConceptsMembrane vesiclesMicrovillus membrane vesiclesRenal microvillus membrane vesiclesSimilar rank order potencyBinding sitesInternal sitesHigh-affinity inhibitorsMembrane localizationInternal binding siteAmiloride analoguesPlasma membraneRank order potencyHigh-affinity bindingAffinity inhibitorsHigh affinity-binding siteVesiclesBasolateral membrane vesiclesOrder potency
1989
Identification and Purification of a Renal Amiloride-binding Protein with Properties of the Na+-H+ Exchanger
Huot SJ, Cassel D, Igarashi P, Cragoe EJ, Slayman CW, Aronson PS. Identification and Purification of a Renal Amiloride-binding Protein with Properties of the Na+-H+ Exchanger. Journal Of Biological Chemistry 1989, 264: 683-686. PMID: 2536021, DOI: 10.1016/s0021-9258(19)84996-7.Peer-Reviewed Original Research
1987
Covalent modification of the renal Na+/H+ exchanger by N,N'-dicyclohexylcarbodiimide.
Igarashi P, Aronson PS. Covalent modification of the renal Na+/H+ exchanger by N,N'-dicyclohexylcarbodiimide. Journal Of Biological Chemistry 1987, 262: 860-868. PMID: 3027072, DOI: 10.1016/s0021-9258(19)75866-9.Peer-Reviewed Original Research
1986
Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.
Grassl SM, Aronson PS. Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Biological Chemistry 1986, 261: 8778-8783. PMID: 3013862, DOI: 10.1016/s0021-9258(19)84448-4.Peer-Reviewed Original ResearchNa-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles
Moseley RH, Meier PJ, Aronson PS, Boyer JL. Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles. American Journal Of Physiology 1986, 250: g35-g43. PMID: 3002192, DOI: 10.1152/ajpgi.1986.250.1.g35.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAcridine OrangeAmilorideAmmoniaAnimalsBasement MembraneBiological Transport, ActiveCarrier ProteinsCell MembraneFiltrationHydrogen-Ion ConcentrationLithiumLiverMaleMembrane PotentialsOsmolar ConcentrationPotassiumRatsRats, Inbred StrainsSodiumSodium-Hydrogen ExchangersValinomycin
1985
Interrelationships among quinidine, amiloride, and lithium as inhibitors of the renal Na+-H+ exchanger.
Mahnensmith RL, Aronson PS. Interrelationships among quinidine, amiloride, and lithium as inhibitors of the renal Na+-H+ exchanger. Journal Of Biological Chemistry 1985, 260: 12586-12592. PMID: 2995381, DOI: 10.1016/s0021-9258(17)38911-1.Peer-Reviewed Original ResearchSodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling
Knickelbein R, Aronson PS, Schron CM, Seifter J, Dobbins JW. Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling. American Journal Of Physiology 1985, 249: g236-g245. PMID: 3927745, DOI: 10.1152/ajpgi.1985.249.2.g236.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAmilorideAnimalsAnionsBicarbonatesCarbonic AnhydrasesChloridesHydrogen-Ion ConcentrationHydroxidesIleumIn Vitro TechniquesIntestinal AbsorptionIntestinal MucosaMembrane PotentialsMicrovilliModels, BiologicalPotassiumRabbitsSodiumConceptsStimulation of ClBrush border membraneCl- uptakeInside-alkaline pH gradientCl transportCl-HCO3 exchangeRabbit ileumCoupling of NaX minMM ClBrush border vesiclesBrush borderN2-5Saturable functionMM KClNa uptakeLevel fourfoldAddition of HCO3K diffusion potentialsCarbonic anhydrase activityChloride transportUptake
1984
Cl- transport via anion exchange in Necturus renal microvillus membranes
Seifter JL, Aronson PS. Cl- transport via anion exchange in Necturus renal microvillus membranes. American Journal Of Physiology 1984, 247: f888-f895. PMID: 6507628, DOI: 10.1152/ajprenal.1984.247.6.f888.Peer-Reviewed Original Research
1983
Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange
Knickelbein R, Aronson PS, Atherton W, Dobbins JW. Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange. American Journal Of Physiology 1983, 245: g504-g510. PMID: 6624918, DOI: 10.1152/ajpgi.1983.245.4.g504.Peer-Reviewed Original ResearchInteraction of external H+ with the Na+-H+ exchanger in renal microvillus membrane vesicles.
Aronson PS, Suhm MA, Nee J. Interaction of external H+ with the Na+-H+ exchanger in renal microvillus membrane vesicles. Journal Of Biological Chemistry 1983, 258: 6767-6771. PMID: 6304054, DOI: 10.1016/s0021-9258(18)32287-7.Peer-Reviewed Original Research
1981
Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesicles
Kinsella JL, Aronson PS. Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesicles. American Journal Of Physiology 1981, 241: f374-f379. PMID: 7315961, DOI: 10.1152/ajprenal.1981.241.4.f374.Peer-Reviewed Original Research