2001
Global Analysis of Protein Activities Using Proteome Chips
Zhu H, Bilgin M, Bangham R, Hall D, Casamayor A, Bertone P, Lan N, Jansen R, Bidlingmaier S, Houfek T, Mitchell T, Miller P, Dean R, Gerstein M, Snyder M. Global Analysis of Protein Activities Using Proteome Chips. Science 2001, 293: 2101-2105. PMID: 11474067, DOI: 10.1126/science.1062191.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceCalmodulinCalmodulin-Binding ProteinsCell MembraneCloning, MolecularFungal ProteinsGlucoseLiposomesMembrane ProteinsMolecular Sequence DataOpen Reading FramesPeptide LibraryPhosphatidylcholinesPhosphatidylinositolsPhospholipidsProtein BindingProteomeRecombinant Fusion ProteinsSaccharomyces cerevisiaeSignal TransductionStreptavidinConceptsYeast proteome microarraysDiverse biochemical activitiesOpen reading framePotential binding motifsProtein-drug interactionsEukaryotic proteomesYeast proteomeProteome chipsPosttranslational modificationsReading frameCorresponding proteinNew calmodulinProtein activityBinding motifBiochemical activityProteome microarrayProteinProteomeMicroarrayCalmodulinGlobal analysisMotifPhospholipidsActivity
1991
SENEX: a computer-based representation of cellular signal transduction processes in the central nervous system
Ball S, Mah V, Miller P. SENEX: a computer-based representation of cellular signal transduction processes in the central nervous system. Bioinformatics 1991, 7: 175-187. PMID: 2059842, DOI: 10.1093/bioinformatics/7.2.175.Peer-Reviewed Original ResearchConceptsCellular signal transduction processesSignal transduction processesTransduction processesSerine/threonine kinasePossible signal transduction pathwaysSignal transduction pathwaysMammalian central nervous systemThreonine kinaseTransduction pathwaysMultisubunit proteinProtein kinaseTyrosine kinaseKinaseCentral nervous systemNervous systemSenexEnzymeInheritance of attributesEnzymatic reactionsSubunitsProteinSpecific retrievalInheritancePathwayFunction