Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells.
Jiang B, Li X, Wang M, Li G, Ren P, Wang Y, Xin S, Qin L. Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells. Journal Of Geriatric Cardiology 2023, 20: 214-222. PMID: 37091261, PMCID: PMC10114191, DOI: 10.26599/1671-5411.2023.03.002.Peer-Reviewed Original ResearchElastase-induced abdominal aortic aneurysmContractile phenotypeAbdominal aortic aneurysm (AAAGieson stainingVehicle-treated miceMeasuring aortic diameterAbdominal aortic aneurysm formationAortic aneurysm formationAbdominal aortic aneurysmTrehalose-treated groupSmooth muscle cellsExpression of autophagy markersVerhoeff-Van Gieson stainSmooth muscle cell contractile phenotypeAutophagy inducerAorta dilatationAortic diameterLeukocyte infiltrationAortic aneurysmVascular histologyDecreased inflammationAAA progressionMouse modelAbdominal aortaMuscle cells