2023
Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells.
Jiang B, Li X, Wang M, Li G, Ren P, Wang Y, Xin S, Qin L. Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells. Journal Of Geriatric Cardiology 2023, 20: 214-222. PMID: 37091261, PMCID: PMC10114191, DOI: 10.26599/1671-5411.2023.03.002.Peer-Reviewed Original ResearchElastase-induced abdominal aortic aneurysmContractile phenotypeAbdominal aortic aneurysm (AAAGieson stainingVehicle-treated miceMeasuring aortic diameterAbdominal aortic aneurysm formationAortic aneurysm formationAbdominal aortic aneurysmTrehalose-treated groupSmooth muscle cellsExpression of autophagy markersVerhoeff-Van Gieson stainSmooth muscle cell contractile phenotypeAutophagy inducerAorta dilatationAortic diameterLeukocyte infiltrationAortic aneurysmVascular histologyDecreased inflammationAAA progressionMouse modelAbdominal aortaMuscle cells
2022
mTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice
He C, Jiang B, Wang M, Ren P, Murtada SI, Caulk AW, Li G, Qin L, Assi R, Lovoulos CJ, Schwartz MA, Humphrey JD, Tellides G. mTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. JCI Insight 2022, 7: e155815. PMID: 35132962, PMCID: PMC8855820, DOI: 10.1172/jci.insight.155815.Peer-Reviewed Original ResearchConceptsApoE-deficient miceAngiotensin IIVascular wall cellsAortic tearAortic ruptureMTOR inhibitionSmooth muscle cell hypertrophyMatricellular proteinWall cellsSuprarenal abdominal aortaMuscle cell hypertrophyExtracellular matrix accumulationInhibition of mTORRole of mTORSubadventitial hematomaFree ruptureAortic dissectionAortic diseaseAortic aneurysmSignificant dissectionAbdominal aortaHemorrhagic lesionsExtensive dissectionMetalloproteinase expressionCell hypertrophy