2022
Endogenous Retroviruses Provide Protection Against Vaginal HSV-2 Disease
Jayewickreme R, Mao T, Philbrick W, Kong Y, Treger RS, Lu P, Rakib T, Dong H, Dang-Lawson M, Guild WA, Lau TJ, Iwasaki A, Tokuyama M. Endogenous Retroviruses Provide Protection Against Vaginal HSV-2 Disease. Frontiers In Immunology 2022, 12: 758721. PMID: 35058919, PMCID: PMC8764156, DOI: 10.3389/fimmu.2021.758721.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndogenous RetrovirusesFemaleHerpes GenitalisHerpesvirus 2, HumanMiceMice, KnockoutVaginal DiseasesConceptsHSV-2 infectionHSV-2 diseaseHerpes simplex virus type 2 infectionSimplex virus type 2 infectionEnhanced type I interferonIntravaginal HSV-2 infectionVaginal HSV-2 infectionVirus type 2 infectionEndogenous retrovirusesReceptor-deficient miceType 2 infectionHigh systemic levelsWildtype C57BL/6 miceType I interferonTLR7-/- miceC57BL/6 miceInfectious endogenous retrovirusDeficient miceIntravaginal applicationAntiviral immunityI interferonVaginal tissueDetrimental functionsTLR7Mice
2017
Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells
Wang Y, Shi J, Yan J, Xiao Z, Hou X, Lu P, Hou S, Mao T, Liu W, Ma Y, Zhang L, Yang X, Qi H. Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells. Nature Immunology 2017, 18: 921-930. PMID: 28650481, DOI: 10.1038/ni.3788.Peer-Reviewed Original Research
2013
MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation
Kang S, Liu W, Lu P, Jin H, Lim H, Shepherd J, Fremgen D, Verdin E, Oldstone M, Qi H, Teijaro J, Xiao C. MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation. Nature Immunology 2013, 14: 849-857. PMID: 23812097, PMCID: PMC3740954, DOI: 10.1038/ni.2648.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell DifferentiationFlow CytometryGerminal CenterImmunity, HumoralImmunohistochemistryInducible T-Cell Co-Stimulator ProteinLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroRNAsNuclear ProteinsPhosphatidylinositol 3-KinasesPhosphoprotein PhosphatasesSignal TransductionSpecific Pathogen-Free OrganismsT-Lymphocytes, Helper-Inducer