2021
Immunohistochemical and molecular pathological typing in the differential diagnosis and prognosis risk assessment of endometrial carcinoma
Wang M, Hui P. Immunohistochemical and molecular pathological typing in the differential diagnosis and prognosis risk assessment of endometrial carcinoma. 中华病理学杂志 2021, 50: 1078-1082. PMID: 34496509, DOI: 10.3760/cma.j.cn112151-20210628-00463.Peer-Reviewed Original Research
2018
MicroRNA signatures discriminate between uterine and ovarian serous carcinomas
Hui P, Gysler SM, Uduman M, Togun TA, Prado DE, Brambs CE, Nallur S, Schwartz PE, Rutherford TJ, Santin AD, Weidhaas JB, Ratner ES. MicroRNA signatures discriminate between uterine and ovarian serous carcinomas. Human Pathology 2018, 76: 133-140. PMID: 29518404, DOI: 10.1016/j.humpath.2018.02.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCarcinomaDiagnosis, DifferentialFemaleGene Expression ProfilingGenetic Predisposition to DiseaseHumansMicroRNAsMiddle AgedNeoplasm GradingNeoplasms, Cystic, Mucinous, and SerousOligonucleotide Array Sequence AnalysisOvarian NeoplasmsPhenotypePredictive Value of TestsReproducibility of ResultsRetrospective StudiesTranscriptomeUterine NeoplasmsConceptsHigh-grade serous carcinomaOvarian serous carcinomaSerous carcinomaOvarian malignancyPrimary ovarian high-grade serous carcinomaOvarian high-grade serous carcinomaMiRNA signatureEndometrial serous carcinomaHigh-grade ovarian serous carcinomaUterine serous carcinomaEndometrial counterpartOvarian primaryTaqMan Low Density Array technologySynchronous primariesEndometrial cancerMetastatic tumorsCarcinomaPrimary siteSignature panelPathological determinationMicroRNA signatureSignificant discriminatory powerCancer cellsMalignancyLineage characteristics
2015
Review of Leiomyoma Variants.
Arleo EK, Schwartz PE, Hui P, McCarthy S. Review of Leiomyoma Variants. American Journal Of Roentgenology 2015, 205: 912-21. PMID: 26397344, DOI: 10.2214/ajr.14.13946.Peer-Reviewed Original ResearchDiagnostic application of KRAS mutation testing in uterine microglandular proliferations
Hong W, Abi-Raad R, Alomari AK, Hui P, Buza N. Diagnostic application of KRAS mutation testing in uterine microglandular proliferations. Human Pathology 2015, 46: 1000-1005. PMID: 25997988, DOI: 10.1016/j.humpath.2015.03.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overBiopsyCell ProliferationCervix UteriDiagnosis, DifferentialDNA Mutational AnalysisEndometrial HyperplasiaEndometrial NeoplasmsFemaleHumansMiddle AgedMutationPredictive Value of TestsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsConceptsKRAS mutation analysisEndometrial adenocarcinomaMicroglandular hyperplasiaMicroglandular patternKRAS mutationsCareful morphological assessmentEndometrial mucinous carcinomaKRAS mutation testingCases of EMAMutation analysisFrequent KRAS mutationsElectronic medical recordsDifferential diagnostic toolHigh mitotic activityEndometrial biopsyImmunohistochemical workupUterine cervixMucinous carcinomaClinical historyDiagnostic challengeDiagnostic dilemmaGlandular proliferationMucinous lesionsMedical recordsEAC cases
2014
Mitotically Active Microglandular Hyperplasia of the Cervix
Abi-Raad R, Alomari A, Hui P, Buza N. Mitotically Active Microglandular Hyperplasia of the Cervix. International Journal Of Gynecological Pathology 2014, 33: 524-530. PMID: 25083971, DOI: 10.1097/pgp.0000000000000086.Peer-Reviewed Original ResearchMeSH KeywordsAdultCervix UteriDiagnosis, DifferentialEndometrial HyperplasiaEndometrial NeoplasmsFemaleHumansHyperplasiaMiddle AgedUterine Cervical NeoplasmsConceptsHuman papillomavirus (HPV) statusMicroglandular hyperplasiaSmall biopsy specimensEndometrial malignancyClinical historyBiopsy specimensHigh risk human papillomavirus statusCarcinoembryonic antigenKi-67 proliferation indexMitotic activityModerate nuclear atypiaPatient's clinical historySignet ring cellsSignificant mitotic activityReticular growth patternMicroglandular patternVimentin immunostainsPatient ageCase seriesEndocervical polypEndometrial adenocarcinomaEndocervical glandsDiagnostic dilemmaClinical prognosisMucinous differentiationInstitutional Review of Primary Non-Hodgkin Lymphoma of the Female Genital Tract
Ahmad AK, Hui P, Litkouhi B, Azodi M, Rutherford T, McCarthy S, Xu ML, Schwartz PE, Ratner E. Institutional Review of Primary Non-Hodgkin Lymphoma of the Female Genital Tract. International Journal Of Gynecological Cancer 2014, 24: 1250-1255. PMID: 25010039, PMCID: PMC8139417, DOI: 10.1097/igc.0000000000000201.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBleomycinCombined Modality TherapyCyclophosphamideCytarabineDiagnosis, DifferentialDoxorubicinFemaleGenital Neoplasms, FemaleGynecologic Surgical ProceduresHumansLymphoma, Non-HodgkinMiddle AgedPrednisolonePrednisonePregnancyPregnancy Complications, NeoplasticRetrospective StudiesSurvival AnalysisTeniposideVincristineYoung AdultConceptsNon-Hodgkin lymphomaFemale genital tractGenital tractGynecologic malignanciesPara-aortic lymph nodesPrimary non-Hodgkin lymphomaDiffuse large B-cell lymphomaYale-New Haven HospitalLarge B-cell lymphomaConcomitant radiation therapyRadical gynecologic surgeryCommon histologic typeOverall median survivalSingle institution experienceStem cell transplantationRare gynecologic malignancyDiagnosis of lymphomaAnn Arbor systemB-cell lymphomaWorld Health OrganizationMedian survivalRecurrent diseaseCombination chemotherapyMedian ageUterine corpus
2013
Partial Hydatidiform Mole
Buza N, Hui P. Partial Hydatidiform Mole. International Journal Of Gynecological Pathology 2013, 32: 307-315. PMID: 23518914, DOI: 10.1097/pgp.0b013e3182626011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChromosome DisordersDiagnosis, DifferentialDNAFemaleGenotypeHumansHydatidiform MolePregnancyRetrospective StudiesUterine NeoplasmsYoung AdultConceptsVillous sizeVillous hydropsMorphologic featuresHigh positive predictive valueCases of PHMSignificant histologic overlapPositive predictive valuePopulations of villusPartial Hydatidiform MoleCistern formationRoutine workupGynecologic pathologistsVillus sizeDefinitive diagnosisHistologic diagnosisHistologic findingsAvailable hematoxylinHistologic overlapDNA genotypingHistologic parametersEosin slidesPredictive valueDiagnostic significanceChromosomal trisomiesTrophoblastic hyperplasia
2012
Relapsing and Remitting Severe Hypoglycemia due to a Monoclonal Anti-insulin Antibody Heralding a Case of Multiple Myeloma
Waldron-Lynch F, Inzucchi SE, Menard L, Tai N, Preston-Hurlburt P, Hui P, McClaskey J, Hagopian WA, Meffre E, Marks PW, Wen L, Herold KC. Relapsing and Remitting Severe Hypoglycemia due to a Monoclonal Anti-insulin Antibody Heralding a Case of Multiple Myeloma. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 4317-4323. PMID: 23074233, PMCID: PMC3513536, DOI: 10.1210/jc.2012-2388.Peer-Reviewed Original ResearchConceptsInsulin autoimmune syndromeAnti-insulin antibodiesMonoclonal anti-insulin antibodiesMultiple myelomaPathogenic antibodiesCases of MMSelf-reactive clonesPrimary multiple myelomaSynchronized courseHepatitis C.Autoimmune syndromeClinical courseSevere hypoglycemiaAntibody subtypesMonoclonal gammopathyPatientsAntibodiesNovel caseHypoglycemiaMyelomaAffinity maturationLongitudinal case historiesLaboratory investigationsTreatmentLow affinity
2008
Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping
Xu ML, Yang B, Carcangiu ML, Hui P. Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping. Modern Pathology 2008, 22: 232-238. PMID: 18820674, DOI: 10.1038/modpathol.2008.165.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Squamous CellComparative Genomic HybridizationDiagnosis, DifferentialEndometrial NeoplasmsEpithelioid CellsFemaleGene Expression Regulation, NeoplasticGenetic TestingGenotypeGestational Trophoblastic DiseaseHumansItalyLung NeoplasmsMiddle AgedPregnancyUnited StatesUterine Cervical NeoplasmsConceptsEpithelioid trophoblastic tumorTrophoblastic tumorSquamous cell carcinomaUterine cervixComparative genomic hybridizationCommon squamous cell carcinomaChromosomal alterationsInvasive squamous cell carcinomaChorionic-type intermediate trophoblastGestational trophoblastic diseaseGenomic hybridizationDNA genotypingIntermediate trophoblastTrophoblastic diseaseAnatomic locationComparative genomic hybridization analysisTrophoblastic originTumorsGenomic hybridization analysisCervixNormal tissuesTrophoblastic natureConventional comparative genomic hybridizationCarcinomaChromosomal profile
2005
HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor
Hui P, Li N, Johnson C, De Wever I, Sciot R, Manfioletti G, Tallini G. HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor. Modern Pathology 2005, 18: 1519-1526. PMID: 16056249, DOI: 10.1038/modpathol.3800464.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsNerve sheath tumorsSheath tumorsSynovial sarcomaSYT-SSX fusion transcriptsRoutine surgical pathology practiceStaining patternMonophasic synovial sarcomaReal-time reverse transcription-polymerase chain reactionAvailable immunohistochemical markersReverse transcription-polymerase chain reactionSurgical pathology practiceTranscription-polymerase chain reactionExpression of HMGA2Nuclear staining patternHistological diagnosisPolymerase chain reactionProtein immunohistochemistryBiphasic tumorSignificant immunoreactivityImmunohistochemical markersImmunohistochemical stainingSarcomaGlandular component
2004
Differential Expression of HMGA1 and HMGA2 in Dermatofibroma and Dermatofibrosarcoma Protuberans: Potential Diagnostic Applications, and Comparison with Histologic Findings, CD34, and Factor XIIIa Immunoreactivity
Li N, McNiff J, Hui P, Manfioletti G, Tallini G. Differential Expression of HMGA1 and HMGA2 in Dermatofibroma and Dermatofibrosarcoma Protuberans: Potential Diagnostic Applications, and Comparison with Histologic Findings, CD34, and Factor XIIIa Immunoreactivity. American Journal Of Dermatopathology 2004, 26: 267-272. PMID: 15249855, DOI: 10.1097/00000372-200408000-00001.Peer-Reviewed Original Research
2003
Real-time Quantitative RT-PCR of Cyclin D1 mRNA in Mantle Cell Lymphoma: Comparison with FISH and Immunohistochemistry
Hui* P, Howe* J, Crouch J, Nimmakayalu M, Qumsiyeh MB, Tallini G, Flynn SD, Smith BR. Real-time Quantitative RT-PCR of Cyclin D1 mRNA in Mantle Cell Lymphoma: Comparison with FISH and Immunohistochemistry. Leukemia & Lymphoma 2003, 44: 1385-1394. PMID: 12952233, DOI: 10.1080/1042819031000079168.Peer-Reviewed Original ResearchCyclin D1Diagnosis, DifferentialFalse Negative ReactionsHumansImmunohistochemistryIn Situ Hybridization, FluorescenceLymphoma, B-CellLymphoma, Mantle-CellReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, NeoplasmSensitivity and SpecificityTranslocation, Genetic