2012
BRAF mutation testing in clinical practice
Ziai J, Hui P. BRAF mutation testing in clinical practice. Expert Review Of Molecular Diagnostics 2012, 12: 127-138. PMID: 22369373, DOI: 10.1586/erm.12.1.Peer-Reviewed Original ResearchMeSH KeywordsDNA Mutational AnalysisHumansMAP Kinase Signaling SystemMolecular Targeted TherapyMutation, MissenseNeoplasmsProtein Structure, TertiaryProto-Oncogene Proteins B-rafConceptsHairy cell leukemiaBRAF mutation testingPapillary thyroid carcinomaMalignant melanomaThyroid carcinomaCell leukemiaClinical practiceCutaneous malignant melanomaSerine/threonine-protein kinase BRAFCurrent clinical practiceImportant biological markerMEK/ERKTreatment paradigmClinical trialsHigh prevalenceBRAF inhibitorsBRAF mutationsMutation testingPrecision cancer therapyTherapeutic guidanceMutant BRAFLethal diseaseBiological markersCancerHuman cancers
2004
STAT3-Mediated Signaling in the Determination of Rod Photoreceptor Cell Fate in Mouse Retina
Zhang SS, Wei J, Qin H, Zhang L, Xie B, Hui P, Deisseroth A, Barnstable CJ, Fu XY. STAT3-Mediated Signaling in the Determination of Rod Photoreceptor Cell Fate in Mouse Retina. Investigative Ophthalmology & Visual Science 2004, 45: 2407-2412. PMID: 15223824, DOI: 10.1167/iovs.04-0003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCalcium-Calmodulin-Dependent Protein KinasesCell DifferentiationCell DivisionCiliary Neurotrophic FactorDNA-Binding ProteinsEnzyme InhibitorsFemaleFlavonoidsFluorescent Antibody Technique, IndirectImmunoenzyme TechniquesInterleukin-6Leukemia Inhibitory FactorMAP Kinase Signaling SystemMiceMitogen-Activated Protein KinasesPregnancyRetinaRetinal Rod Photoreceptor CellsSignal TransductionSTAT3 Transcription FactorTrans-ActivatorsConceptsMitogen-activated protein kinaseCiliary neurotrophic factorLeukemia inhibitory factorPhotoreceptor cell fateCell fate decisionsRod photoreceptor cell fateRod photoreceptor differentiationDominant negative STAT3Mouse retina developmentActivator of transcriptionMAPK inhibitor PD98059Activation of STAT3Fate decisionsCell fateTransduction pathwaysProtein kinasePhotoreceptor developmentRod developmentSignal transducerInhibitor PD98059Photoreceptor differentiationRetina explant culturesMouse retinaMAPK pathwayRetina development