2020
Genital tuberculosis screening at an academic fertility center in the United States
Tal R, Lawal T, Granger E, Simoni M, Hui P, Buza N, Pal L. Genital tuberculosis screening at an academic fertility center in the United States. American Journal Of Obstetrics And Gynecology 2020, 223: 737.e1-737.e10. PMID: 32497612, DOI: 10.1016/j.ajog.2020.05.045.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, HabitualAcademic Medical CentersAdultEndometritisEndometriumFemaleFertility ClinicsGynatresiaHumansIncidenceInfertility, FemaleInterferon-gamma Release TestsLatent TuberculosisMass ScreeningMycobacterium tuberculosisPolymerase Chain ReactionProspective StudiesTuberculosis, Female GenitalUnited StatesYoung AdultConceptsFemale genital tuberculosisQuantiFERON-TB GoldGenital tuberculosisAcademic fertility centerLatent tuberculosisChest X-rayPositive test resultsFertility centerPolymerase chain reactionEndometrial biopsyMycobacterium tuberculosisChain reactionQuantiFERON-TB Gold resultsProspective cohort studyRecurrent pregnancy lossReproductive technology treatmentAcid-fast bacilliMultiple diagnostic modalitiesNegative test resultsGranulomatous endometritisNeonatal complicationsEndometrial samplingNeonatal morbidityCohort studyAsherman's syndrome
2018
Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation
Wu X, Snir O, Rottmann D, Wong S, Buza N, Hui P. Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation. Modern Pathology 2018, 32: 650-658. PMID: 30443012, DOI: 10.1038/s41379-018-0179-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkers, TumorColorectal Neoplasms, Hereditary NonpolyposisDNA-Binding ProteinsEndometrial NeoplasmsFemaleGenetic LociGenetic Predisposition to DiseaseHumansImmunohistochemistryMicrosatellite InstabilityMiddle AgedMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinPhenotypePolymerase Chain ReactionPredictive Value of TestsReproducibility of ResultsConceptsEndometrial cancerMLH1/PMS2Endometrial carcinomaMSH6 lossMicrosatellite shiftCancer cohortMismatch repair deficiency testingMicrosatellite instability-high colorectal cancerEndometrial cancer cohortLoss of PMS2Clear cell carcinomaColorectal cancer cohortHigh colorectal cancerLynch syndrome familiesMSH2/MSH6PMS2 lossCell carcinomaColorectal cancerDeficiency testingSolid malignanciesColorectal carcinomaCarcinomaCancerIsolated lossMSH-6
2014
Genotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament
Buza N, Rutherford T, Hui P. Genotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament. International Journal Of Gynecological Pathology 2014, 33: 58-63. PMID: 24300537, DOI: 10.1097/pgp.0b013e31827cd386.Peer-Reviewed Original ResearchMeSH KeywordsBroad LigamentChoriocarcinoma, Non-gestationalFallopian Tube NeoplasmsFemaleGenotypeHumansPolymerase Chain ReactionYoung AdultConceptsBroad ligamentFallopian tubePelvic lymph node metastasisMultiagent chemotherapy regimenRecurrence 26 monthsRight adnexal massRight fallopian tubeLymph node metastasisOnly necrotic tissueLast menstrual periodLarge tumor massMicroscopic examinationChemotherapy regimenEctopic pregnancyMultiagent chemotherapyNongestational choriocarcinomaPure choriocarcinomaNode metastasisPatient ageInitial diagnosisInitial presentationGestational choriocarcinomaAdnexal massesFinal diagnosisEmergency room
2013
Screening for EGFR and KRAS mutations in non-small cell lung carcinomas using DNA extraction by hydrothermal pressure coupled with PCR-based direct sequencing.
Liu Y, Wu BQ, Zhong HH, Hui P, Fang WG. Screening for EGFR and KRAS mutations in non-small cell lung carcinomas using DNA extraction by hydrothermal pressure coupled with PCR-based direct sequencing. International Journal Of Clinical And Experimental Pathology 2013, 6: 1880-9. PMID: 24040454, PMCID: PMC3759496.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAdultAgedAged, 80 and overBiopsyCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellDNA Mutational AnalysisErbB ReceptorsExonsFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic TestingHumansLung NeoplasmsMaleMiddle AgedMutationParaffin EmbeddingPhenotypePolymerase Chain ReactionPrecision MedicinePredictive Value of TestsPressurePrognosisProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsTissue FixationYoung AdultConceptsNon-small cell lung carcinomaCore needle biopsyCell lung carcinomaKRAS mutationsNSCLC patientsSurgical resectionEGFR mutationsLung carcinomaNeedle biopsyKRAS mutation analysisTyrosine kinase inhibitorsKRAS gene mutationsDirect sequencingMutation analysisFemale patientsAdenocarcinoma componentLung cancerPatientsEGFRExon 19Kinase inhibitorsExon 18Gene mutationsStatistical significanceResection
2011
Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions
Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-234. PMID: 21732551, DOI: 10.1002/cncy.20172.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsHR-HPV testingHPV testingCIN 2Colposcopy rateHR-HPVRelative light units/cutoffCervical intraepithelial neoplasia 2High-risk human papillomavirusHR-HPV statusRLU/COIntraepithelial neoplasia 2Hybrid Capture 2Squamous intraepithelial lesionsCIN 1 lesionsLarge teaching hospitalNegative predictive valueLSIL cytologyHPV statusIntraepithelial lesionsCapture 2Human papillomavirusTeaching hospitalCytologic diagnosisSevere lesions
2010
Molecular diagnosis of gestational trophoblastic disease
Hui P. Molecular diagnosis of gestational trophoblastic disease. Expert Review Of Molecular Diagnostics 2010, 10: 1023-1034. PMID: 21080819, DOI: 10.1586/erm.10.93.Peer-Reviewed Original ResearchGlial Heterotopia of the Uterine Cervix: DNA Genotyping Confirmation of its Fetal Origin
Siddon A, Hui P. Glial Heterotopia of the Uterine Cervix: DNA Genotyping Confirmation of its Fetal Origin. International Journal Of Gynecological Pathology 2010, 29: 394-397. PMID: 20567155, DOI: 10.1097/pgp.0b013e3181c5a7e8.Peer-Reviewed Original ResearchConceptsGlial heterotopiaUterine cervixGlial tissueKlinefelter syndromeFetal originGlial fibrillary acidic proteinMature glial tissueFibrillary acidic proteinDown syndrome fetusesFetal brain tissueEndocervical glandular epitheliumFetal tissue samplesS100 immunohistochemistryCervical polypsCervical lesionsElective terminationIntriguing lesionsPregnancy terminationIdentical genetic profilesSyndrome fetusesGlandular epitheliumSyndromeBrain tissueFirst gestationDown syndrome
2009
Anaplastic oligoastrocytoma in Turcot syndrome
Baehring J, Hui P, Piepmeier J, Bannykh SI. Anaplastic oligoastrocytoma in Turcot syndrome. Journal Of Neuro-Oncology 2009, 95: 293-298. PMID: 19495563, DOI: 10.1007/s11060-009-9928-y.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesAgedAstrocytomaColorectal Neoplasms, Hereditary NonpolyposisDNA Repair EnzymesDNA-Binding ProteinsDNA, NeoplasmFemaleHumansImmunoenzyme TechniquesMagnetic Resonance ImagingMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinNuclear ProteinsPedigreePolymerase Chain ReactionConceptsHereditary non-polyposis colorectal cancerTurcot syndromeAnaplastic oligoastrocytomaNon-polyposis colorectal cancerYear old womanHandful of casesColorectal cancerLarge bowelDNA mismatch repair systemOlder womenBrain tumorsTumor DNABody sitesFamilial clusteringGermline mutationsRare variantsSyndromeOligoastrocytomasCancerMismatch repair systemChance occurrenceDetailed molecular dataBowelPathogenesisTumors
2008
Lack of Genetic Association Between Exaggerated Placental Site Reaction and Placental Site Trophoblastic Tumor
Jorge D, Hui P. Lack of Genetic Association Between Exaggerated Placental Site Reaction and Placental Site Trophoblastic Tumor. International Journal Of Gynecological Pathology 2008, 27: 562-567. PMID: 18753963, DOI: 10.1097/pgp.0b013e31816d1d00.Peer-Reviewed Original ResearchConceptsPaternal X chromosomeGenotypic Analysis of Hydatidiform Mole: An Accurate and Practical Method of Diagnosis
Bifulco C, Johnson C, Hao L, Kermalli H, Bell S, Hui P. Genotypic Analysis of Hydatidiform Mole: An Accurate and Practical Method of Diagnosis. The American Journal Of Surgical Pathology 2008, 32: 445-451. PMID: 18300805, DOI: 10.1097/pas.0b013e3181520034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleGenotypeHomozygoteHumansHydatidiform MoleImmunohistochemistryMiddle AgedPloidiesPolymerase Chain ReactionPregnancyUterine NeoplasmsConceptsMolar pregnancyMaternal endometrial tissuesDaily clinical practiceDNA ploidy analysisDNA genotypingCases of HMUnstained paraffin sectionsHistologic featuresEndometrial tissueMorphologic mimicsClinical practiceMolar gestationHydatidiform MoleParaffin sectionsChorionic villiDiagnosisRoutine diagnosisPregnancyPloidy analysisGenotypic analysisGenotypingPaternal originPCR amplification systemGestationCasesSynovial Sarcoma of the Stomach
Makhlouf HR, Ahrens W, Agarwal B, Dow N, Marshalleck JJ, Lee EL, Dotto JE, Hui P, Sobin LH, Oliveira A, Miettinen M. Synovial Sarcoma of the Stomach. The American Journal Of Surgical Pathology 2008, 32: 275-281. PMID: 18223331, DOI: 10.1097/pas.0b013e31812e6a58.Peer-Reviewed Original ResearchConceptsSynovial sarcomaTumor sizeSYT-SSX fusion transcriptsGastric synovial sarcomaGastric primary tumorSpindle cell neoplasmRound cell componentFocal keratinPartial gastrectomyPostoperative radiationMedian ageSegmental resectionVariable prognosisRecurrence 6Immunohistochemical featuresPrimary tumorKIT immunoreactivityMicroscopic calcificationCell neoplasmsTumors 25Differential diagnosisGastrointestinal tractOval lesionTransmural massPatientsPrimary or Secondary? Genotyping Confirmation of an Ovarian Primary Carcinoid Tumor
Dotto J, Mezzetti T, Hui P. Primary or Secondary? Genotyping Confirmation of an Ovarian Primary Carcinoid Tumor. International Journal Of Gynecological Pathology 2008, 27: 33-36. PMID: 18156971, DOI: 10.1097/pgp.0b13e318053df4.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoid TumorDiabetes Mellitus, Type 2FemaleGenotypeHumansHypertensionImmunohistochemistryLymphatic MetastasisMiddle AgedObesityOvarian NeoplasmsPolymerase Chain ReactionConceptsPrimary carcinoid tumorCarcinoid tumorsGerm cell originCell originInsular carcinoid tumorPure histological typePrimary ovarian tumorsSignificant diagnostic challengeExtraovarian tumorMetastatic carcinoidLymphovascular invasionHistological typeOvarian tumorsMetastatic tumorsClinical managementDiagnostic challengeTeratomatous componentsGastrointestinal tractTumorsAdditional studiesDNA genotypingCarcinoidsPrognosisTractWomen
2005
Atypical angiomyolipoma of kidney in a patient with tuberous sclerosis: a case report with p53 gene mutation analysis.
Ma L, Kowalski D, Javed K, Hui P. Atypical angiomyolipoma of kidney in a patient with tuberous sclerosis: a case report with p53 gene mutation analysis. Archives Of Pathology & Laboratory Medicine 2005, 129: 676-9. PMID: 15859641, DOI: 10.5858/2005-129-0676-aaokia.Peer-Reviewed Original ResearchConceptsHMB-45Tuberous sclerosisP53 mutationsPerivascular epithelioid cell tumorCommon benign mesenchymal tumorsFocal p53 immunoreactivityP53 gene mutation analysisSmooth muscle-like cellsEpithelioid cell tumorBenign mesenchymal tumorsMuscle-like cellsGene mutation analysisAtypical angiomyolipomaEpithelioid angiomyolipomaRenal angiomyolipomaCase reportMesenchymal tumorsCell tumorsAML progressionAML casesP53 immunoreactivityFrequent mitosesP53 abnormalitiesAngiomyolipomaEpithelioid cells
2004
Human herpesvirus‐8 is not associated with angiolymphoid hyperplasia with eosinophilia
Bhattacharjee P, Hui P, McNiff J. Human herpesvirus‐8 is not associated with angiolymphoid hyperplasia with eosinophilia. Journal Of Cutaneous Pathology 2004, 31: 612-615. PMID: 15330993, DOI: 10.1111/j.0303-6987.2004.00240.x.Peer-Reviewed Original ResearchConceptsHHV-8 DNAHHV-8Immunohistochemical studyHuman herpesvirus 8 DNACases of ALHEMultiple red papulesHuman herpesvirus 8Majority of casesPolymerase chain reaction analysisAngiolymphoid hyperplasiaRed papulesKaposi's sarcomaALHEHerpesvirus 8Chain reaction analysisAngioproliferative lesionsNeck regionRemaining tissueEosinophiliaSarcomaHyperplasiaContradictory dataAssociationReaction analysisPCR analysis
2002
Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma)
Hui P, Glusac EJ, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). Journal Of Cutaneous Pathology 2002, 29: 385-389. PMID: 12139632, DOI: 10.1034/j.1600-0560.2002.290701.x.Peer-Reviewed Original ResearchMeSH KeywordsChromosomes, Human, XClone CellsDNA, NeoplasmDosage Compensation, GeneticFemaleHistiocytoma, Benign FibrousHumansPolymerase Chain ReactionReceptors, AndrogenSkin NeoplasmsConceptsCutaneous fibrous histiocytomaDermatofibrosarcoma protuberansFibrous histiocytomaAR allelesCommon benign fibrohistiocytic lesionBenign fibrohistiocytic lesionsReactive fibroblastic proliferationCell typesCases of dermatofibromaAndrogen receptor geneMixed cell typeNeoplastic cell typesHistiocytoid featuresDeep fibrous histiocytomaFemale patientsHistological typeFibrohistiocytic lesionsHistiocytoid cellsInflammatory process
2001
Assessment of clonality in melanocytic nevi
Hui P, Perkins A, Glusac E. Assessment of clonality in melanocytic nevi. Journal Of Cutaneous Pathology 2001, 28: 140-144. PMID: 11168766, DOI: 10.1034/j.1600-0560.2001.028003140.x.Peer-Reviewed Original Research