TH17 cells mediate pulmonary collateral priming
Albrecht M, Chen HC, Preston-Hurlburt P, Ranney P, Hoymann HG, Maxeiner J, Staudt V, Taube C, Bottomly HK, Dittrich AM. TH17 cells mediate pulmonary collateral priming. Journal Of Allergy And Clinical Immunology 2011, 128: 168-177.e8. PMID: 21459426, PMCID: PMC3129446, DOI: 10.1016/j.jaci.2011.01.067.Peer-Reviewed Original ResearchConceptsCollateral primingAirway inflammationNew antigensAirway hyperresponsivenessIL-17AT cellsMemory/effector phenotypeCognate antigenLymphocytic airway inflammationStronger airway hyperresponsivenessIL-17A secretionEndogenous T cellsAirway responsivenessIgG2a levelsOngoing inflammationTh17 cellsAllergic sensitizationLymphocytic inflammationEffector phenotypePulmonary inflammationInflammatory phenotypeUnrelated antigensMurine modelInflammationCongenic mice