The role of tyrosine at the ligand-binding site of the nicotinic acetylcholine receptor
Pearce S, Preston-Hurlburt P, Hawrot E. The role of tyrosine at the ligand-binding site of the nicotinic acetylcholine receptor. Proceedings Of The Royal Society B 1990, 241: 207-213. PMID: 1979446, DOI: 10.1098/rspb.1990.0087.Peer-Reviewed Original ResearchConceptsLigand-binding siteNegative subsiteInvariant tyrosine residueNicotinic acetylcholine receptorsValuable structural informationDetailed structural knowledgeReceptor ligand-binding siteCationic ligandsFluorescence spectroscopicAcetylcholine receptorsRole of tyrosineCritical residuesLigand recognitionTyrosine residuesLigand bindingStructural comparisonStructural informationPeptide fragmentsLigandsPosition 190Receptor actionNeurotransmitter receptorsSpecific ligandsStructural knowledgeResiduesMonoclonal antibodies directed against a synthetic peptide corresponding to the α-bungarotoxin binding region of the acetylcholine receptor
Preston-Hurlburt P, Wilson P, Dowding A, Hawrot E. Monoclonal antibodies directed against a synthetic peptide corresponding to the α-bungarotoxin binding region of the acetylcholine receptor. Biochimica Et Biophysica Acta 1990, 1033: 324-328. PMID: 2317509, DOI: 10.1016/0304-4165(90)90141-i.Peer-Reviewed Original Research