The role of tyrosine at the ligand-binding site of the nicotinic acetylcholine receptor
Pearce S, Preston-Hurlburt P, Hawrot E. The role of tyrosine at the ligand-binding site of the nicotinic acetylcholine receptor. Proceedings Of The Royal Society B 1990, 241: 207-213. PMID: 1979446, DOI: 10.1098/rspb.1990.0087.Peer-Reviewed Original ResearchConceptsLigand-binding siteNegative subsiteInvariant tyrosine residueNicotinic acetylcholine receptorsValuable structural informationDetailed structural knowledgeReceptor ligand-binding siteCationic ligandsFluorescence spectroscopicAcetylcholine receptorsRole of tyrosineCritical residuesLigand recognitionTyrosine residuesLigand bindingStructural comparisonStructural informationPeptide fragmentsLigandsPosition 190Receptor actionNeurotransmitter receptorsSpecific ligandsStructural knowledgeResidues