2002
Dual receptor T cells extend the immune repertoire for foreign antigens
He X, Janeway CA, Levine M, Robinson E, Preston-Hurlburt P, Viret C, Bottomly K. Dual receptor T cells extend the immune repertoire for foreign antigens. Nature Immunology 2002, 3: 127-134. PMID: 11812989, DOI: 10.1038/ni751.Peer-Reviewed Original ResearchConceptsDual TCR cellsT cell receptorTCR cellsForeign antigensT cellsDual-receptor T cellsFunctional T cell receptorSecond T cell receptorReceptor T cellsAutoimmune potentialIntrathymic selectionTCR repertoireNormal miceImmune responseImmune systemCell receptorNaïve repertoireAntigenClonal expansionImmune repertoireBeneficial roleCellsMost studiesMiceReceptors
1998
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationDrosophilaDrosophila ProteinsHumansInterleukin-1 Receptor-Associated KinasesMembrane GlycoproteinsMembrane ProteinsMyeloid Differentiation Factor 88NF-kappa BProtein KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsTranscription Factor AP-1ConceptsIL-1R familyNF-kappaB activationNF-kappaB pathwayImmune response genesToll/IL-1R familyAP-1 activationImmune responseIL-1RTRAF6 proteinInnate immunityNF-kappaBMyD88Drosophila Toll proteinReceptor familyToll receptorAdaptor proteinSignaling pathwaysReceptorsActivationToll proteinRegulator moleculesResponse genesAdult DrosophilaPathwayProtein
1990
Monoclonal antibodies directed against a synthetic peptide corresponding to the α-bungarotoxin binding region of the acetylcholine receptor
Preston-Hurlburt P, Wilson P, Dowding A, Hawrot E. Monoclonal antibodies directed against a synthetic peptide corresponding to the α-bungarotoxin binding region of the acetylcholine receptor. Biochimica Et Biophysica Acta 1990, 1033: 324-328. PMID: 2317509, DOI: 10.1016/0304-4165(90)90141-i.Peer-Reviewed Original Research