2013
Specific peripheral B cell tolerance defects in patients with multiple sclerosis
Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O’Connor K, Meffre E. Specific peripheral B cell tolerance defects in patients with multiple sclerosis. Journal Of Clinical Investigation 2013, 123: 2737-2741. PMID: 23676463, PMCID: PMC3668812, DOI: 10.1172/jci68775.Peer-Reviewed Original ResearchConceptsB cell tolerance checkpointsB cell tolerance defectsMultiple sclerosisRheumatoid arthritisTolerance checkpointsB cellsPeripheral B cell tolerance checkpointsTolerance defectsAutoreactive B cell clonesMature naive B cellsType 1 diabetesAutoreactive B cellsB cell toleranceCentral nervous systemNaive B cellsB cell clonesB cell selectionEarly B cell developmentIPEX patientsMost patientsTreg functionHomeostatic proliferationAutoimmune diseasesPatientsHealthy individuals
1993
Rules for the Presentation of Peptides by Class II Molecules of the Major Histocompatibility Complex
Janeway C, Preston-Hurlburt P, Al-Ramadi B, Rothbard J, Murphy D, Reich E, Rudensky A. Rules for the Presentation of Peptides by Class II Molecules of the Major Histocompatibility Complex. 1993, 181-188. DOI: 10.1007/978-3-642-51479-1_24.Peer-Reviewed Original ResearchCD4 T cellsClass II moleculesMHC class II moleculesMajor histocompatibility complexT cellsSelf peptidesSelf toleranceCD8 cytolytic T cellsHistocompatibility complexT cell responsesAdaptive immune responsesCytolytic T cellsSelf-MHC recognitionPresentation of peptidesCD4 TImmune responseAdaptive immunityMHC recognitionB cellsSpecific antigenCell responsesCellsPeptidesSingle peptide