2006
A limited number of genes are involved in the differentiation of germinal center B cells
Nakayama Y, Stabach P, Maher SE, Mahajan MC, Masiar P, Liao C, Zhang X, Ye Z, Tuck D, Bothwell AL, Newburger PE, Weissman SM. A limited number of genes are involved in the differentiation of germinal center B cells. Journal Of Cellular Biochemistry 2006, 99: 1308-1325. PMID: 16795035, DOI: 10.1002/jcb.20952.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell DifferentiationCell LineChildChild, PreschoolDithiothreitolDNA-Binding ProteinsGene Expression ProfilingGerminal CenterHumansMolecular Sequence DataNuclear ProteinsOligonucleotide Array Sequence AnalysisPalatine TonsilProtein FoldingRegulatory Factor X Transcription FactorsTranscription FactorsTunicamycinX-Box Binding Protein 1ConceptsUnfolded protein responseX-box binding protein 1Interferon regulatory factor 4Protein 1B lymphocyte-induced maturation protein-1Transcription factor B lymphocyte-induced maturation protein-1Post-transcriptional changesBinding protein 1Maturation protein-1Mature B cellsDisulfide isomeraseTranscription factorsLevel of expressionPlasmacytoma cell lineProtein responseGene expressionRegulatory factor 4GenesGerminal center B cellsLymphoblastoid cellsLimited inductionCell linesB cellsFactor 4Germinal center centroblasts
2005
AP2α alters the transcriptional activity and stability of p53
Stabach P, Thiyagarajan M, Woodfield G, Weigel R. AP2α alters the transcriptional activity and stability of p53. Oncogene 2005, 25: 2148-2159. PMID: 16288208, DOI: 10.1038/sj.onc.1209250.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsChromatin ImmunoprecipitationColonic NeoplasmsCyclin-Dependent Kinase Inhibitor p21Gene Expression Regulation, NeoplasticGenes, ReporterHumansImmunoprecipitationLiver NeoplasmsPoint MutationPromoter Regions, GeneticProtein BindingTranscription Factor AP-2Transcription, GeneticTranscriptional ActivationTumor Cells, CulturedTumor Suppressor Protein p53ConceptsTranscriptional activityEndogenous p53 target genesEndogenous p21 geneNormal transcriptional activityP53 target genesP53-mediated inductionAmino acids 305Stability of p53Expression of aP2Transcriptional coactivationP21WAF1/CIP1P21 promoterTarget genesCertain genesRegion of p53AP2αReporter assaysP21 geneFunctional partnershipP53 stabilityP53 activityCell growthPoint mutationsAP2Genes