2023
Continuous non-invasive hemodynamic monitoring in early onset severe preeclampsia
Ackerman-Banks C, Bhinder J, Eder M, Heerdt P, Sugeng L, Testani J, Alian A, Lipkind H, Velazquez E, Reddy U, Chou J. Continuous non-invasive hemodynamic monitoring in early onset severe preeclampsia. Pregnancy Hypertension 2023, 34: 27-32. PMID: 37783090, DOI: 10.1016/j.preghy.2023.09.003.Peer-Reviewed Original ResearchConceptsTotal peripheral resistanceCardiac outputSevere preeclampsiaHemodynamic monitoringEarly-onset severe preeclampsiaProspective observational studyOnset severe preeclampsiaContinuous hemodynamic monitoringNon-invasive hemodynamic monitoringEarly preeclampsiaPregnant patientsPeripheral resistanceObservational studyPreeclampsiaLow mean biasDays postpartumNICOMModerate correlationPoor correlationMean biasAntepartumPatientsIntegrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application
Heerdt P, Martin-Flores M, Oakland H, Joseph P, Singh I. Integrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1929-1937. PMID: 37422337, PMCID: PMC10529383, DOI: 10.1053/j.jvca.2023.06.011.Peer-Reviewed Original ResearchConceptsRight heart catheterizationHeart catheterizationDiastolic functionRV volumesBeat measuresDiagnostic right heart catheterizationReference standardRight ventricular contractilityEnd-diastolic pressurePressure waveform analysisEnd-systolic elastancePotential clinical utilityClinical applicationRV volume measurementsVolume measurementsRV contractilityRV systolicVentricular contractilityRV pressureBland-Altman analysisClinical utilityAnesthetized swineNitric oxideExperimental modelContractility
2020
The glymphatic system and its role in cerebral homeostasis
Benveniste H, Elkin R, Heerdt P, Koundal S, Xue Y, Lee H, Wardlaw J, Tannenbaum A. The glymphatic system and its role in cerebral homeostasis. Journal Of Applied Physiology 2020, 129: 1330-1340. PMID: 33002383, PMCID: PMC7792843, DOI: 10.1152/japplphysiol.00852.2019.Peer-Reviewed Original Research
2019
Glymphatic System Function in Relation to Anesthesia and Sleep States
Benveniste H, Heerdt PM, Fontes M, Rothman DL, Volkow ND. Glymphatic System Function in Relation to Anesthesia and Sleep States. Anesthesia & Analgesia 2019, 128: 747-758. PMID: 30883420, DOI: 10.1213/ane.0000000000004069.Peer-Reviewed Original ResearchConceptsEye movement sleepGlymphatic systemMovement sleepNon-rapid eye movement sleepRapid eye movement (REM) sleepTight blood-brain barrierCentral nervous system tissueCerebral oxygen consumptionCritical care settingBlood-brain barrierGlymphatic system functionCentral nervous systemNervous system tissueCerebrospinal fluid flowAnesthetic regimensBrain glymphatic systemBrain parenchymaCognitive dysfunctionCare settingsNervous systemClinical explorationWaste clearanceWakefulness persistLymphatic systemKey anatomical components
2018
Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine.
Savarese JJ, Sunaga H, McGilvra JD, Belmont MR, Murrell MT, Jeannotte E, Cooke FE, Wastila WB, Heerdt PM. Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine. Anesthesiology 2018, 129: 970-988. PMID: 30212413, DOI: 10.1097/aln.0000000000002408.Peer-Reviewed Original ResearchConceptsNeuromuscular blocking agentsMean arterial pressureBlocking agentArterial pressureNeuromuscular blockadeHeart rateNew neuromuscular blocking agentRhesus monkeysNondepolarizing neuromuscular blocking agentDuration of actionStudy of bolusCirculatory effectsPreclinical pharmacologyControl infusionInstitutional Animal CareED95Large dosesSpontaneous recoveryGantacuriumDose ratioL-cysteineInfusionBolusUse CommitteeRecovery intervalBlood Pressure Targets in Perioperative Care
Meng L, Yu W, Wang T, Zhang L, Heerdt PM, Gelb AW. Blood Pressure Targets in Perioperative Care. Hypertension 2018, 72: 806-817. PMID: 30354725, DOI: 10.1161/hypertensionaha.118.11688.Peer-Reviewed Original ResearchPharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers
Kaullen JD, Owen JS, Brouwer KLR, Heerdt PM, Lien CA, Savarese JJ, Schmith VD. Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers. Anesthesiology 2018, 128: 1107-1116. PMID: 29494403, PMCID: PMC5953789, DOI: 10.1097/aln.0000000000002157.Peer-Reviewed Original ResearchConceptsNeuromuscular blocking agentsBlocking agentRapid onsetPharmacodynamic modelDifferent dose cohortsMuscle twitch heightOffset of effectSingle ascending dosePharmacokinetic/Pharmacodynamic ModelArterial plasma concentrationsIntermediate durationPlasma drug concentration dataSigmoid Emax modelDose-response studyDrug concentration dataConcentration-time dataLow interindividual variabilityDose cohortsED95 dosesAscending dosePredictable pharmacokineticsSevoflurane anesthesiaPopulation pharmacokineticsSingle dosesTwitch heightPerioperative pulmonary thromboembolism
Ruohoniemi DM, Sista AK, Doany CF, Heerdt PM. Perioperative pulmonary thromboembolism. Current Opinion In Anaesthesiology 2018, 31: 75-82. PMID: 29206697, DOI: 10.1097/aco.0000000000000550.Peer-Reviewed Original ResearchConceptsSubmassive pulmonary emboliCatheter-directed therapyPulmonary emboliSystemic anticoagulationIntervention efficacyMean pulmonary artery pressurePerioperative pulmonary thromboembolismPulmonary artery pressureCurrent treatment optionsWarrants further investigationInadequacy of treatmentArtery pressurePulmonary thromboembolismPostoperative patientsPulmonary embolismRelative contraindicationSurgical patientsAggressive interventionIntraoperative embolizationPerioperative patientsTreatment optionsOptimizing therapyPromising efficacyElevated riskVentricular monitoring
2017
Bridging the Educational Gap in Thoracic Anesthesia
Popescu WM, Heerdt PM. Bridging the Educational Gap in Thoracic Anesthesia. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 31: 1359-1360. PMID: 28800993, DOI: 10.1053/j.jvca.2017.05.021.Peer-Reviewed Original ResearchSingle-lung ventilation and oxidative stress
Heerdt PM, Stowe DF. Single-lung ventilation and oxidative stress. Current Opinion In Anaesthesiology 2017, 30: 42-49. PMID: 27783023, DOI: 10.1097/aco.0000000000000410.Peer-Reviewed Original ResearchConceptsSingle-lung ventilationOxidative stressRe-expanded lungHypoxic pulmonary vasoconstrictionRedistribution of bloodLocal tissue hypoxiaPostoperative disruptionPulmonary vasoconstrictionReperfusion responseAtelectatic lungTissue hypoxiaClinical dataReactive oxygenSystemic effectsOrgan functionLungNitrosative stressVentilationNitrogen speciesVasoconstrictionAnesthesia for nonintubated video-assisted thoracic surgery
Sunaga H, Blasberg JD, Heerdt PM. Anesthesia for nonintubated video-assisted thoracic surgery. Current Opinion In Anaesthesiology 2017, 30: 1-6. PMID: 27906718, DOI: 10.1097/aco.0000000000000413.Peer-Reviewed Original Research
2016
Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
Heerdt PM, Sunaga H, Owen JS, Murrell MT, Malhotra JK, Godfrey D, Steinkamp M, Savard P, Savarese JJ, Lien CA. Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man. Anesthesiology 2016, 125: 1136-1143. PMID: 27749289, DOI: 10.1097/aln.0000000000001386.Peer-Reviewed Original ResearchConceptsCardiopulmonary side effectsHistamine releaseSide effectsBlood pressureHealthy subjectsHeart rateSevoflurane/nitrous oxideDose-escalation clinical trialDynamic airway complianceNeuromuscular-blocking drugsEscalation clinical trialPlasma histamine concentrationSigmoid Emax modelClinical recoveryClinical durationAdductor pollicisTwitch depressionAirway complianceNeuromuscular blockadeClinical trialsPreclinical studiesArterial bloodEmax modelHistamine concentrationCW002
2015
Non-invasive cardiac output monitoring for cesarean delivery under epidural anesthesia in a patient with Marfan syndrome and cardiomyopathy
Beaudry S, Pick J, Heerdt P. Non-invasive cardiac output monitoring for cesarean delivery under epidural anesthesia in a patient with Marfan syndrome and cardiomyopathy. International Journal Of Obstetric Anesthesia 2015, 25: 82-85. PMID: 26718697, DOI: 10.1016/j.ijoa.2015.11.003.Peer-Reviewed Original ResearchConceptsNon-invasive cardiac output monitoringCardiac outputCardiac output monitoringCesarean deliveryStroke volumeEpidural anesthesiaBaseline valuesMarfan syndromeLeft ventricular ejection fractionOutput monitoringUse of phenylephrineEnd of surgeryIntravascular volume depletionMaternal cardiac outputMitral valve replacementSystemic blood pressureAdequate surgical anesthesiaClose hemodynamic monitoringVentricular ejection fractionAcute blood lossAcute volume overloadStroke volume increaseValve replacementBlood lossBlood pressureNovel neuromuscular blocking drugs and antagonists
Heerdt PM, Sunaga H, Savarese JJ. Novel neuromuscular blocking drugs and antagonists. Current Opinion In Anaesthesiology 2015, 28: 403-410. PMID: 26087274, DOI: 10.1097/aco.0000000000000209.Peer-Reviewed Original ResearchConceptsMuscle relaxantsClinical trialsNeuromuscular blocking drugsNondepolarizing muscle relaxantsNew muscle relaxantsL-cysteine injectionNondepolarizing drugSugammadex reversalBlocking drugsHistamine releasePreclinical studiesComplete paralysisCysteine injectionClinical developmentCW002RelaxantsRapid reversalIntermediate durationDrugsGantacuriumTrialsInjectionDurationRocuroniumSugammadex
2014
Regulation of Protein Phosphatase 1I by Cdc25C-associated Kinase 1 (C-TAK1) and PFTAIRE Protein Kinase*
Platholi J, Federman A, Detert JA, Heerdt P, Hemmings HC. Regulation of Protein Phosphatase 1I by Cdc25C-associated Kinase 1 (C-TAK1) and PFTAIRE Protein Kinase*. Journal Of Biological Chemistry 2014, 289: 23893-23900. PMID: 25028520, PMCID: PMC4156073, DOI: 10.1074/jbc.m114.557744.Peer-Reviewed Original ResearchConceptsProtein phosphatase 1IC-TAK1Protein kinaseKinase 1GSK-3Protein phosphatase 1Phosphatase activityPP-1cThr-72Multisite phosphorylationActivating residuesPhosphatase 1Regulatory subunitSer-86Ser-71Subsequent phosphorylationMajor endogenous formsInhibitor 2PhosphorylationKinaseCdc25CEndogenous formPFTK1ResiduesActivation
2012
Anesthesia and Pulmonary Hypertension
McGlothlin D, Ivascu N, Heerdt PM. Anesthesia and Pulmonary Hypertension. Progress In Cardiovascular Diseases 2012, 55: 199-217. PMID: 23009916, DOI: 10.1016/j.pcad.2012.08.002.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionNon-cardiothoracic surgeryThorough multidisciplinary planningOperative risk factorsRight ventricular failurePulmonary arterial hypertensionPreoperative risk assessmentCareful intraoperative managementArterial hypertensionPostoperative complicationsPostoperative hypoxemiaVentricular failureCardiac surgeryIntraoperative managementAnesthetic approachEarly recognitionMyocardial ischemiaRisk factorsMultidisciplinary planningHypertensionPatientsSurgerySuccessful managementAnesthesiaHypoxemia
2011
Letter to the Editor: Response to Ballestero et al
Heerdt PM. Letter to the Editor: Response to Ballestero et al. Pediatric Cardiology 2011, 32: 866-867. PMID: 21509496, DOI: 10.1007/s00246-011-9992-x.Peer-Reviewed Original Research
2010
Bivalirudin utilization in cardiac surgery: shifting anticoagulation from indirect to direct thrombin inhibition
Anand SX, Viles-Gonzalez JF, Mahboobi SK, Heerdt PM. Bivalirudin utilization in cardiac surgery: shifting anticoagulation from indirect to direct thrombin inhibition. Journal Canadien D'anesthésie 2010, 58: 296-311. PMID: 21136312, DOI: 10.1007/s12630-010-9423-0.Peer-Reviewed Original ResearchConceptsVascular graft patencyCardiac surgerySurgical proceduresGraft patencyCoronary artery bypass graft proceduresThrombin inhibitionCardiac Surgery (SYNTAX) trialBypass graft proceduresCardiac surgical proceduresVascular surgical proceduresOptimal clinical outcomesDirect thrombin inhibitionAdditional relevant articlesAnticoagulation protocolCardiopulmonary bypassUnfractionated heparinClinical outcomesSimilar safetySurgery TrialEfficacy profilePotential complicationsGraft proceduresUnited States National LibraryCardiac anesthesiologistsReference lists
2009
Case report: paradoxical ventricular septal motion in the setting of primary right ventricular myocardial failure
Maslow A, Schwartz C, Mahmood F, Singh A, Heerdt PM. Case report: paradoxical ventricular septal motion in the setting of primary right ventricular myocardial failure. Journal Canadien D'anesthésie 2009, 56: 510-517. PMID: 19475470, DOI: 10.1007/s12630-009-9108-8.Peer-Reviewed Original ResearchConceptsRV myocardial tissueRV ejectionSystemic hypotensionSeptal motionParadoxical ventricular septal motionMyocardial tissueRV fractional areaVentricular septal motionEnd-organ dysfunctionRight heart failureRight ventricular failureMitral valve replacementVentricular systolic functionEarly postoperative periodSystemic organ failureSystemic organ functionSystolic septal motionMultiple inotropesVasopressor administrationVentricular failureEchocardiographic evaluationHemodynamic instabilityInotropic medicationsPostoperative periodSystolic functionPostoperative care after pulmonary resection: postanesthesia care unit versus intensive care unit
Pedoto A, Heerdt PM. Postoperative care after pulmonary resection: postanesthesia care unit versus intensive care unit. Current Opinion In Anaesthesiology 2009, 22: 50. PMID: 19295292, DOI: 10.1097/aco.0b013e32831d7b25.Peer-Reviewed Original ResearchConceptsLength of stayElective lung resectionPostanesthesia care unitLung resectionCare unitPostoperative careElective ICU admissionSevere postoperative complicationsHigh-risk patientsImmediate postoperative careNoncardiac thoracic surgeryIntensive care unitPerioperative patient careComplex surgical casesPostoperative areaICU admissionPostoperative complicationsPulmonary resectionPreoperative evaluationAnesthetic techniqueOptimal careLung cancerThoracic surgeryHospital costsSurgical cases