Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Su SC, Hu X, Kenney PA, Merrill MM, Babaian KN, Zhang XY, Maity T, Yang SF, Lin X, Wood CG. Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma. Clinical Cancer Research 2013, 19: 6461-6472. PMID: 24122794, PMCID: PMC4191899, DOI: 10.1158/1078-0432.ccr-13-1284.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsCarcinogenesisCarcinoma, Renal CellCell Line, TumorCell MovementDrug Resistance, NeoplasmFemaleHuman Umbilical Vein Endothelial CellsHumansIndolesKidney NeoplasmsLysophospholipidsMiceMice, Inbred BALB CMice, NudeMicrovesselsNeoplasm InvasivenessPhosphoric Diester HydrolasesPyrrolesSignal TransductionSunitinibTranscriptomeTumor BurdenXenograft Model Antitumor AssaysConceptsLPA receptor 1Lysophosphatidic acidATX-LPAResistance of RCCRenal cell carcinomaGene expression profilesExtracellular lysophospholipase DRCC cell linesTarget genesCell motilityEndothelial cellsExpression profilesIntracellular signalingInvasion responsesRCC tumorigenesisHuman renal cell carcinomaSignaling AxisSensitivity of RCCRCC cellsFunctional roleXenograft modelAltered expressionRenal tumorigenesisCell carcinomaLysophospholipase D