2020
Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma
Hsiang WR, Kenney PA, Leapman MS. Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma. Current Oncology Reports 2020, 22: 35. PMID: 32170461, DOI: 10.1007/s11912-020-0895-y.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Renal CellCytoreduction Surgical ProceduresHumansKidney NeoplasmsMetastasectomyNephrectomyPrognosisRisk FactorsSurvival AnalysisTreatment OutcomeConceptsMetastatic renal cell carcinomaSystemic therapyRenal cell carcinomaCytoreductive nephrectomySurgical therapyCell carcinomaManagement of mRCCPoor-risk metastatic renal cell carcinomaInitial systemic therapyReviewThe treatment landscapeTargeted therapy eraUpfront cytoreductive nephrectomyViable treatment approachSequence of surgeryTherapy eraTreatment landscapeUnselected patientsSurgical managementSummaryRecent evidenceRecent FindingsOneTreatment approachesNephrectomyTherapyOptimal rolePatients
2015
Prediction of Pulmonary Metastasis in Renal Cell Carcinoma Patients with Indeterminate Pulmonary Nodules
Adibi M, Kenney PA, Thomas AZ, Borregales LD, Nogueras-González GM, Wang X, Devine CE, Karam JA, Wood CG. Prediction of Pulmonary Metastasis in Renal Cell Carcinoma Patients with Indeterminate Pulmonary Nodules. European Urology 2015, 69: 352-360. PMID: 26382085, DOI: 10.1016/j.eururo.2015.08.053.Peer-Reviewed Original ResearchConceptsLung metastasis-free survivalIndeterminate pulmonary nodulesRenal cell carcinomaAdvanced renal cell carcinomaPulmonary metastasesCell carcinomaPulmonary nodulesMultivariable Cox regression modelsRenal cell carcinoma patientsRadical nephrectomy patientsCell carcinoma patientsMetastasis-free survivalCox regression modelIndividualized risk stratificationAvailable preoperative imagingKidney cancer patientsSmall lung nodulesThree yrNephrectomy patientsPreoperative chestOverall cohortCarcinoma patientsDistant metastasisPathological variablesRadical nephrectomyMucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes
Kenney PA, Vikram R, Prasad SR, Tamboli P, Matin SF, Wood CG, Karam JA. Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes. BJU International 2015, 116: 85-92. PMID: 25395040, DOI: 10.1111/bju.12992.Peer-Reviewed Original ResearchConceptsSpindle cell carcinomaCell carcinomaSingle-institution retrospective analysisContrast-enhanced computed tomographyRenal cell carcinoma variantsPT3a diseaseOncological outcomesSalvage surgeryClinical characteristicsMetastatic diseaseFemale predominanceMedian ageClinical outcomesRadical nephrectomyFemale predilectionExcellent outcomesPathological featuresCarcinoma variantsSarcomatoid dedifferentiationActive surveillanceHistological featuresRetrospective analysisEnergy ablationComputed tomographyPapillary RCC
2014
Preoperative Predictors of Pathological Lymph Node Metastasis in Patients with Renal Cell Carcinoma Undergoing Retroperitoneal Lymph Node Dissection
Babaian KN, Kim DY, Kenney PA, Wood CG, Wong J, Sanchez C, Fang JE, Gerber JA, Didic A, Wahab A, Golla V, Torres C, Tamboli P, Qiao W, Matin SF, Wood CG, Karam JA. Preoperative Predictors of Pathological Lymph Node Metastasis in Patients with Renal Cell Carcinoma Undergoing Retroperitoneal Lymph Node Dissection. Journal Of Urology 2014, 193: 1101-1107. PMID: 25390078, DOI: 10.1016/j.juro.2014.10.096.Peer-Reviewed Original ResearchConceptsRetroperitoneal lymph node dissectionLymph node dissectionRenal cell carcinomaNode dissectionPositive lymph nodesRecurrence-free survivalLymph node metastasisCell carcinomaECOG PSPreoperative predictorsLymph nodesDistant metastasisNode metastasisLocal symptomsCN stageM0 renal cell carcinomaAdvanced renal cell carcinomaPathological lymph node metastasisPreoperative clinical predictorsKaplan-Meier methodLactate dehydrogenasePatients 131PN1 casesPN0 diseasePredictive nomogram
2013
Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Su SC, Hu X, Kenney PA, Merrill MM, Babaian KN, Zhang XY, Maity T, Yang SF, Lin X, Wood CG. Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma. Clinical Cancer Research 2013, 19: 6461-6472. PMID: 24122794, PMCID: PMC4191899, DOI: 10.1158/1078-0432.ccr-13-1284.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsCarcinogenesisCarcinoma, Renal CellCell Line, TumorCell MovementDrug Resistance, NeoplasmFemaleHuman Umbilical Vein Endothelial CellsHumansIndolesKidney NeoplasmsLysophospholipidsMiceMice, Inbred BALB CMice, NudeMicrovesselsNeoplasm InvasivenessPhosphoric Diester HydrolasesPyrrolesSignal TransductionSunitinibTranscriptomeTumor BurdenXenograft Model Antitumor AssaysConceptsLPA receptor 1Lysophosphatidic acidATX-LPAResistance of RCCRenal cell carcinomaGene expression profilesExtracellular lysophospholipase DRCC cell linesTarget genesCell motilityEndothelial cellsExpression profilesIntracellular signalingInvasion responsesRCC tumorigenesisHuman renal cell carcinomaSignaling AxisSensitivity of RCCRCC cellsFunctional roleXenograft modelAltered expressionRenal tumorigenesisCell carcinomaLysophospholipase DPreoperative Pulmonary Embolism Does Not Predict Poor Postoperative Outcomes in Patients with Renal Cell Carcinoma and Venous Thrombus
Abel EJ, Wood CG, Eickstaedt N, Fang JE, Kenney P, Bagrodia A, Youssef RF, Sagalowsky AI, Margulis V. Preoperative Pulmonary Embolism Does Not Predict Poor Postoperative Outcomes in Patients with Renal Cell Carcinoma and Venous Thrombus. Journal Of Urology 2013, 190: 452-457. PMID: 23434945, DOI: 10.1016/j.juro.2013.02.033.Peer-Reviewed Original ResearchConceptsPreoperative pulmonary embolismCancer-specific survivalRenal cell carcinomaPulmonary embolismPoor postoperative outcomesCell carcinomaSpecific survivalVenous thrombiPostoperative outcomesMetastatic renal cell carcinomaCox proportional hazards analysisWorse cancer-specific survivalConsecutive patient recordsHigh-level thrombusProportional hazards analysisHigher T stagePostoperative disease recurrencePerioperative mortalityMedian followupDisease recurrenceTumor thrombusT stageTertiary hospitalEarly mortalityMulticenter study
2012
Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma
Kenney PA, Wood CG. Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma. Urologic Clinics Of North America 2012, 39: 211-231. PMID: 22487764, DOI: 10.1016/j.ucl.2012.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, HormonalCarcinoma, Renal CellChemotherapy, AdjuvantCombined Modality TherapyFemaleHumansImmunotherapyKidney NeoplasmsMaleNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm StagingNephrectomyPrognosisRadiotherapy, AdjuvantRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsRenal cell carcinomaSystemic therapyCell carcinomaMetastatic renal cell carcinomaAdvanced nonmetastatic diseaseUpfront cytoreductive nephrectomyIntegration of surgeryCytoreductive nephrectomyCytoreductive surgeryNeoadjuvant therapyNonmetastatic diseaseAdjuvant therapyMetastatic diseaseAppropriate patientsTherapySurgeryDiseaseCurrent roleNephrectomyFurther studiesCarcinomaPotential benefitsPatientsTrialsHIGHER PERIOPERATIVE MORBIDITY AND IN‐HOSPITAL MORTALITY IN PATIENTS WITH END‐STAGE RENAL DISEASE UNDERGOING NEPHRECTOMY FOR NON‐METASTATIC KIDNEY CANCER: A POPULATION‐BASED ANALYSIS
Kenney PA, Karam JA. HIGHER PERIOPERATIVE MORBIDITY AND IN‐HOSPITAL MORTALITY IN PATIENTS WITH END‐STAGE RENAL DISEASE UNDERGOING NEPHRECTOMY FOR NON‐METASTATIC KIDNEY CANCER: A POPULATION‐BASED ANALYSIS. BJU International 2012, 110: e191-e191. PMID: 22321381, DOI: 10.1111/j.1464-410x.2012.11018.x.Peer-Reviewed Original Research
2010
Comparison of hilar clamping and non‐hilar clamping partial nephrectomy for tumours involving a solitary kidney
Wszolek MF, Kenney PA, Lee Y, Libertino JA. Comparison of hilar clamping and non‐hilar clamping partial nephrectomy for tumours involving a solitary kidney. BJU International 2010, 107: 1886-1892. PMID: 21070570, DOI: 10.1111/j.1464-410x.2010.09713.x.Peer-Reviewed Original ResearchConceptsLatest glomerular filtration ratesGlomerular filtration rateNon-clamping groupEarly glomerular filtration ratePreoperative glomerular filtration rateSolitary functional kidneyHilar clampingPartial nephrectomyClamping groupSolitary kidneySpecific survivalRenal cell carcinoma-specific survivalInstitutional review board-approved retrospective reviewSurgical margin positivity ratesFunctional kidneyMean ischaemia timeSimilar cancer controlRenal Disease equationLocal recurrence rateMargin positivity ratesModification of DietCarcinoma-specific survivalSpectrum of complicationsNumber of tumorsAutotransplant proceduresNon‐clamped partial nephrectomy: techniques and surgical outcomes
Smith GL, Kenney PA, Lee Y, Libertino JA. Non‐clamped partial nephrectomy: techniques and surgical outcomes. BJU International 2010, 107: 1054-1058. PMID: 21040369, DOI: 10.1111/j.1464-410x.2010.09798.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Renal CellConstrictionEpidemiologic MethodsFemaleHumansKidney NeoplasmsMaleMiddle AgedNephrectomyReperfusion InjuryTreatment OutcomeConceptsPartial nephrectomyVascular clampingGroup AGroup BSolitary kidneyRenal functionBlood lossOncological efficacyPercentage changeVon Hippel-Lindau diseaseFour-variable ModificationRenal vascular clampingMedian tumor sizeRate of complicationsRenal Disease equationGlomerular filtration rateSubset of patientsMedian percentage changeRate of recurrencePositive margin rateHippel-Lindau diseaseUnclamped groupPerioperative deathsPreoperative eGFRRetrospective review