2020
Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma
Hsiang WR, Kenney PA, Leapman MS. Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma. Current Oncology Reports 2020, 22: 35. PMID: 32170461, DOI: 10.1007/s11912-020-0895-y.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaSystemic therapyRenal cell carcinomaCytoreductive nephrectomySurgical therapyCell carcinomaManagement of mRCCPoor-risk metastatic renal cell carcinomaInitial systemic therapyReviewThe treatment landscapeTargeted therapy eraUpfront cytoreductive nephrectomyViable treatment approachSequence of surgeryTherapy eraTreatment landscapeUnselected patientsSurgical managementSummaryRecent evidenceRecent FindingsOneTreatment approachesNephrectomyTherapyOptimal rolePatients
2013
Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma
Kenney P, Wood C. Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma. 2013, 155-177. DOI: 10.1007/978-1-4614-7236-0_10.Peer-Reviewed Original ResearchSystemic therapyBenefit of cytoreductionTargeted therapy eraVenous tumor thrombusRenal cell carcinomaTyrosine kinase inhibitorsAdjuvant settingUnresectable diseaseAdvanced diseaseCytoreductive surgeryNeoadjuvant therapyTherapy eraAdjuvant therapyMetastatic RCCTumor thrombusGenitourinary malignanciesCell carcinomaPartial nephrectomySurgeryTherapyEffective agentMonoclonal antibodiesKinase inhibitorsDiseaseCurrent role
2012
Nodal disease in the setting of metastatic renal cell carcionoma: Can a lymph node dissection alter outcomes?
Chapin B, Delacroix S, Kenney P, Nogueras Gonzalez G, Tamboli P, Jonasch E, Tannir N, Wood C. Nodal disease in the setting of metastatic renal cell carcionoma: Can a lymph node dissection alter outcomes? Journal Of Clinical Oncology 2012, 30: 386-386. DOI: 10.1200/jco.2012.30.5_suppl.386.Peer-Reviewed Original ResearchLymph node dissectionMetastatic renal cell carcinomaCytoreductive nephrectomyOverall survivalCN0 patientsNodal diseasePN0 patientsWorse OSCox proportional hazards regressionClinical node statusTargeted therapy eraMedian overall survivalPost-operative complicationsWorse median OSProportional hazards regressionRenal cell carcinomaLong-axis diameterImproved OSMedian OSTherapy eraNode dissectionClavien systemLN statusPositive diseaseComplete resection