2011
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo
Isern J, He Z, Fraser ST, Nowotschin S, Ferrer-Vaquer A, Moore R, Hadjantonakis AK, Schulz V, Tuck D, Gallagher PG, Baron MH. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood 2011, 117: 4924-4934. PMID: 21263157, PMCID: PMC3100699, DOI: 10.1182/blood-2010-10-313676.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell LineageCytokinesDNA PrimersEpsilon-GlobinsErythroid Precursor CellsErythropoiesisFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Regulatory NetworksGlycolysisGreen Fluorescent ProteinsGrowth SubstancesMaleMiceMice, Inbred ICRMice, TransgenicOxygenPregnancyRecombinant Fusion ProteinsRNA, MessengerSignal TransductionConceptsPrimitive erythroid progenitorsMouse embryosErythroid progenitorsGlobal expression profilesEmbryonic day 7.5Critical regulatory factorKey regulatory pathwaysOnset of circulationFirst transcriptomeRemarkable proliferative capacityTranscript diversityTransgenic reporterTranscriptome analysisFirst cell typeRegulatory pathwaysHematopoietic lineagesExpression profilesRegulatory factorsCell typesDay 7.5EmbryosProgenitorsYolk sacBlood progenitorsGlycolytic profile
2009
Genome Expression Profiling of the First Hematopoietic Progenitors of the Mouse Embryo.
Baron M, Isern J, Fraser S, He Z, Tuck D, Schulz V, Gallagher P. Genome Expression Profiling of the First Hematopoietic Progenitors of the Mouse Embryo. Blood 2009, 114: 2536. DOI: 10.1182/blood.v114.22.2536.2536.Peer-Reviewed Original ResearchGenome expression profilingMouse embryosGFP reporterExpression profilingErythroid lineageLineage-specific cell typesEmbryonic globin genesDefinitive erythroid lineagesHematopoietic progenitorsGlobin gene expressionCandidate transcriptional regulatorsCell typesPrimitive erythroid lineageLineage-specific expressionEarly mouse embryosAnalysis of promotersEnd of gastrulationEmbryonic day 7.5Hematopoietic cell typesEarly hematopoietic progenitorsExpression of GATA2Distinct functional classesOrganelle biogenesisRibosome biogenesisPrimitive erythropoiesis