Identification of a Novel Core Promoter Element That Enhances Transcription: Application to Ankyrin Promoters for Globin Gene Therapy.
Laflamme K, Elnitski L, Owen A, Gallagher P, Bodine D. Identification of a Novel Core Promoter Element That Enhances Transcription: Application to Ankyrin Promoters for Globin Gene Therapy. Blood 2006, 108: 3261. DOI: 10.1182/blood.v108.11.3261.3261.Peer-Reviewed Original ResearchGC-rich promoterLocus control regionΓ-globin expressionHematopoietic stem cellsTG dinucleotideErythroid cellsNovel core promoter elementΑ-globinDifferent tissue-specific promotersLike globin genesBinding regionsΓ-globin transcriptionANK-1 geneTranscription initiation complexΓ-globin geneErythroid K562 cellsConsensus promoter sequenceTranscriptional start siteCore promoter elementsRNA virus vectorMouse erythroid cellsK562 cellsStable transfection assaysWild-type promoterTissue-specific promoters