2015
Arbitration between Action Strategies in Obsessive-Compulsive Disorder
Gruner P, Anticevic A, Lee D, Pittenger C. Arbitration between Action Strategies in Obsessive-Compulsive Disorder. The Neuroscientist 2015, 22: 188-198. PMID: 25605642, PMCID: PMC5159480, DOI: 10.1177/1073858414568317.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDecision MakingHumansLearningNeuroimagingObsessive-Compulsive DisorderPrefrontal CortexConceptsObsessive-compulsive disorderModel-based decisionDivergent behavioral outcomesContext-appropriate mannerFunctional imaging findingsCognitive remediationHypothesized deficitProcedural learningAutomatic processLearning taskCompulsive disorderBehavioral outcomesEvaluative processFruitful targetCorresponding circuitryPredictable regularityAction strategiesDeficitsLearningExcessive relianceComplex worldInappropriate recruitmentFunctional weaknessReinforcement learning algorithmDynamic arbitration
2014
Independent component analysis of resting state activity in pediatric obsessive‐compulsive disorder
Gruner P, Vo A, Argyelan M, Ikuta T, Degnan AJ, John M, Peters BD, Malhotra AK, Uluğ AM, Szeszko PR. Independent component analysis of resting state activity in pediatric obsessive‐compulsive disorder. Human Brain Mapping 2014, 35: 5306-5315. PMID: 24867148, PMCID: PMC4169329, DOI: 10.1002/hbm.22551.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingChildFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNerve NetObsessive-Compulsive DisorderOxygenPediatricsRestConceptsPosterior cingulate networkObsessive-compulsive disorderPediatric obsessive-compulsive disorderHealthy volunteersCingulate networkExpression scoreSpatial group independent component analysisVisual networkState functional magnetic resonanceCourse of illnessHigher expression scoresPediatric OCD patientsAnterior cingulate networkDorsal anterior cingulateFunctional magnetic resonancePatterns of brainGroup independent component analysisPharmacologic interventionsClinical correlatesPatientsAnterior cingulateGreater severityCingulate cortexFMRI abnormalitiesLogistic regression
2012
White Matter Abnormalities in Pediatric Obsessive-Compulsive Disorder
Gruner P, Vo A, Ikuta T, Mahon K, Peters BD, Malhotra AK, Uluğ AM, Szeszko PR. White Matter Abnormalities in Pediatric Obsessive-Compulsive Disorder. Neuropsychopharmacology 2012, 37: 2730-2739. PMID: 22871914, PMCID: PMC3473339, DOI: 10.1038/npp.2012.138.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderDorsal cingulum bundleFractional anisotropyYale-Brown ObsessiveCingulum bundleGreater fractional anisotropyT GE systemDrug-naïve patientsCourse of illnessNeurobiology of OCDPatients' symptom severityWhite matter abnormalitiesPediatric OCD patientsRight corticospinal tractWhite matter deficitsPediatric obsessive-compulsive disorderInferior fronto-occipital fasciculusLower fractional anisotropyWhite matter tractsChildren's Yale-Brown ObsessiveFronto-occipital fasciculusResponse inhibition functionHigher fractional anisotropyPediatric patientsCorticospinal tract