2001
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack D, Rakic P. Cell Proliferation Without Neurogenesis in Adult Primate Neocortex. Science 2001, 294: 2127-2130. PMID: 11739948, DOI: 10.1126/science.1065467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainBromodeoxyuridineCell DeathCell DivisionCell MovementEndothelium, VascularFemaleFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinImmunoenzyme TechniquesMacaca fascicularisMacaca mulattaMaleMicroscopy, ConfocalMicroscopy, FluorescenceNeocortexNeuronsNuclear ProteinsTubulinConceptsPrimate neocortexGlial cell markersAdult macaque monkeysNew neuronsNumerous BrdUOlfactory bulbCerebral wallAdult macaquesMacaque monkeysNonneuronal cellsHigher cognitive functionsCell markersCognitive functionNeocortexNeurogenesisTriple labelingCellular mechanismsCell proliferationNeuronsCellsHippocampus
2000
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain
Laywell E, Rakic P, Kukekov V, Holland E, Steindler D. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 13883-13888. PMID: 11095732, PMCID: PMC17670, DOI: 10.1073/pnas.250471697.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainCell LineageGlial Fibrillary Acidic ProteinImmunohistochemistryMiceMicroscopy, ElectronStem CellsConceptsCentral nervous systemNeural stem cellsAstrocyte monolayersMultipotent astrocytic stem cellsAstrocytic stem cellsPostnatal central nervous systemAdult mouse brainStem cellsCerebral cortexPostnatal wkSpinal cordAdult brainSubependymal zoneNervous systemEpendymal cellsMouse brainMammalian brainSpherical clonesCNS developmentBrainVivo identificationAstrocytesMature forebrainCritical periodCE cells
1999
Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1
Haydar T, Bambrick L, Krueger B, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1. Brain Research 1999, 4: 425-437. PMID: 10592354, DOI: 10.1016/s1385-299x(99)00033-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBromodeoxyuridineCell DivisionCell MovementCell SurvivalFemaleFetusFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinIn Situ Nick-End LabelingMiceMice, Inbred ICRMicroscopy, ConfocalMicrotubule-Associated ProteinsNeocortexNeurogliaNeuronsOrgan Culture TechniquesPregnancyConceptsCell deathProper cortical developmentCell-cell interactionsDynamic cellular interactionsQuantitative confocal microscopyDiffusible regulatorsPrimary cell culturesAnalysis of proliferationCellular interactionsCellular mechanismsCortical neurogenesisNeuronal migrationConfocal microscopyCell proliferationNeocortical neurogenesisExperimental manipulationThree-dimensional environmentVivo processesCell culturesNeurogenesisPhysiological methodsTropic supportOrganotypic slice culturesProliferationCortical development
1990
Cytological and quantitative characteristics of four cerebral commissures in the rhesus monkey
Lamantia A, Rakic P. Cytological and quantitative characteristics of four cerebral commissures in the rhesus monkey. The Journal Of Comparative Neurology 1990, 291: 520-537. PMID: 2329189, DOI: 10.1002/cne.902910404.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCell CountCorpus CallosumFemaleGlial Fibrillary Acidic ProteinMacacaMacaca mulattaMaleNeurogliaConceptsGlial fibrillary acidic proteinAnterior commissureCorpus callosumHippocampal commissureTelencephalic commissuresCerebral commissureNeocortical commissuresUnmyelinated axonsRhesus monkeysNumber of axonsPrimary sensory cortexGFAP-positive cellsFibrillary acidic proteinLarge myelinated axonsQuantitative electron microscopic analysisClasses of axonsNumerous desmosomal junctionsAdult rhesus monkeysAxonal compositionOpposite cerebralNeurons projectAssociation projectionsUnmyelinated fibersAxonal fasciclesGlia cells
1988
Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey
Eckenhoff M, Rakic P. Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey. Journal Of Neuroscience 1988, 8: 2729-2747. PMID: 3411351, PMCID: PMC6569394, DOI: 10.1523/jneurosci.08-08-02729.1988.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyCell DivisionGlial Fibrillary Acidic ProteinHippocampusImmunohistochemistryMacacaMacaca mulattaMicroscopy, ElectronThymidineConceptsProliferative cellsMitotic divisionPostmitotic cellsUltra-structural characteristicsPossible functionsElectron microscopic levelStable populationGlial fibrillary acidic proteinNeuronal cellsStem cellsJuvenile periodMajor classesMature primatesSubgranular zoneDentate gyrusGlial cellsLife spanCellsGFAP-negative cellsFateRhesus monkeysAcidic proteinNew neuronsPostpubertal animalsFibrillary acidic protein
1985
DNA Synthesis and Cell Division in the Adult Primate Braina
RAKIC P. DNA Synthesis and Cell Division in the Adult Primate Braina. Annals Of The New York Academy Of Sciences 1985, 457: 193-211. PMID: 3913364, DOI: 10.1111/j.1749-6632.1985.tb20806.x.Peer-Reviewed Original ResearchConceptsPostembryonic neurogenesisNonmammalian vertebratesCell divisionDNA precursorsPrimate central nervous systemStable populationDNA synthesisNonprimate mammalsCentral nervous systemMature primatesNeuronal additionGlial cellsNervous systemAdult monkeysRetention of memoryAutoradiographic analysisMultiple injectionsVertebratesDevelopmental periodMammalsVariable degreesNeuronsJuvenilesNeurogenesisTurnover
1983
Early divergence and changing proportions of neuronal and glial precursor cells in the primate cerebral ventricular zone
Levitt P, Cooper M, Rakic P. Early divergence and changing proportions of neuronal and glial precursor cells in the primate cerebral ventricular zone. Developmental Biology 1983, 96: 472-484. PMID: 6339301, DOI: 10.1016/0012-1606(83)90184-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGestational AgeGlial Fibrillary Acidic ProteinHistocytochemistryImmunoenzyme TechniquesIntermediate Filament ProteinsMacaca mulattaMicroscopy, ElectronMitosisNeurogliaNeuronsOccipital LobeConceptsGlial fibrillary acidic proteinVentricular zoneRhesus monkey fetusesPrecursor cellsFibrillary acidic proteinGFA-positive cellsCerebral ventricular zoneGlial precursor cellsNeuronal precursor cellsMonkey fetusesGestational periodProliferative ventricular zoneOccipital lobePrimate brainImmunocytochemical stainingAcidic proteinMitotic figuresCellular compositionEmbryonic ageCellsElectron microscopic analysisEarly divergenceFetusesPresent resultsNeurons
1981
Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis
Levitt P, Cooper M, Rakic P. Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis. Journal Of Neuroscience 1981, 1: 27-39. PMID: 7050307, PMCID: PMC6564162, DOI: 10.1523/jneurosci.01-01-00027.1981.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell DivisionCerebral CortexFetusGlial Fibrillary Acidic ProteinImmunoenzyme TechniquesMacaca mulattaMicroscopy, ElectronNerve Tissue ProteinsNeurogliaNeuronsOccipital LobeConceptsGlial fibrillary acid proteinLast cell divisionCell divisionRadial glial cellsNeuronal cell lineAcid proteinCerebral ventricular zoneEmbryonic day 80Proliferative zoneGlial precursor cellsMitotic cycleCell typesPeak of neurogenesisPrecursor cellsCell linesVentricular zoneElectron microscopic levelFetal monkeysProliferative cellsGlial cellsSubventricular zoneOccipital lobePhenotypic expressionCytological compositionDistinct classes