2001
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
Oppenheim R, Flavell R, Vinsant S, Prevette D, Kuan C, Rakic P. Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases. Journal Of Neuroscience 2001, 21: 4752-4760. PMID: 11425902, PMCID: PMC6762357, DOI: 10.1523/jneurosci.21-13-04752.2001.Peer-Reviewed Original ResearchConceptsCell deathGenetic deletionExtensive cytoplasmic vacuolizationPro-apoptotic proteasesCaspase familySpecific caspasesChromatin condensationNonapoptotic pathwaysPostmitotic neuronsCaspase-9Mammalian neuronsCell typesDeath processSpecific perturbationsCaspase-3Altered morphologyCaspasesNuclear changesKey membersDeletionUTP nickCytoplasmic vacuolizationElectron microscopic levelTerminal deoxynucleotidyl transferase-mediated biotinylated UTP nickNeuronal populations
1999
Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1
Haydar T, Bambrick L, Krueger B, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1. Brain Research 1999, 4: 425-437. PMID: 10592354, DOI: 10.1016/s1385-299x(99)00033-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBromodeoxyuridineCell DivisionCell MovementCell SurvivalFemaleFetusFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinIn Situ Nick-End LabelingMiceMice, Inbred ICRMicroscopy, ConfocalMicrotubule-Associated ProteinsNeocortexNeurogliaNeuronsOrgan Culture TechniquesPregnancyConceptsCell deathProper cortical developmentCell-cell interactionsDynamic cellular interactionsQuantitative confocal microscopyDiffusible regulatorsPrimary cell culturesAnalysis of proliferationCellular interactionsCellular mechanismsCortical neurogenesisNeuronal migrationConfocal microscopyCell proliferationNeocortical neurogenesisExperimental manipulationThree-dimensional environmentVivo processesCell culturesNeurogenesisPhysiological methodsTropic supportOrganotypic slice culturesProliferationCortical development
1990
Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain
Kostovic I, Rakic P. Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain. The Journal Of Comparative Neurology 1990, 297: 441-470. PMID: 2398142, DOI: 10.1002/cne.902970309.Peer-Reviewed Original ResearchConceptsSubplate zoneTransient subplate zoneCortical plateSomatosensory cortexSubcortical white matterSubplate neuronsBasal forebrainBrain stemContralateral cerebralGlial cellsPostmigratory neuronsSomatosensory areaFetal brainOccipital lobeCerebral convolutionsCerebral wallFiber terminalsHuman fetusesWhite matterMacaque monkeysVisual areasCortexGestationFiber-rich layersHistochemical methods
1981
Neurogenetic gradients in the superior and inferior colliculi of the rhesus monkey
Cooper M, Rakic P. Neurogenetic gradients in the superior and inferior colliculi of the rhesus monkey. The Journal Of Comparative Neurology 1981, 202: 309-334. PMID: 7298901, DOI: 10.1002/cne.902020303.Peer-Reviewed Original ResearchConceptsSuperior colliculusInferior colliculusCentral nucleusInferior colliculiRhesus monkeysVentrodorsal gradientLateral-medial gradientAnterior-posterior gradientTectal neuronsNeurogenetic gradientsPeak proliferationSubventricular zoneSelective cell deathRostrocaudal gradientCNS cellsFinal mitosisNeuronsDistinctive spatiotemporal patternsNeurogenesisEmbryonic dayColliculiColliculusGestation periodCell deathLateral cell movement
1978
Transient Synapses in the Embryonic Primate Spinal Cord
Knyihar E, Csillik B, Rakic P. Transient Synapses in the Embryonic Primate Spinal Cord. Science 1978, 202: 1206-1209. PMID: 103200, DOI: 10.1126/science.103200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCell SurvivalDendritesGestational AgeHaplorhiniMacaca mulattaSpinal CordSynapses