2024
Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors
Morozov Y, Rakic P. Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors. Cerebral Cortex 2024, 34: bhae293. PMID: 39024157, PMCID: PMC11485267, DOI: 10.1093/cercor/bhae293.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsProgenitor cellsVentricular zoneCerebral cortexBasolateral cell membraneApical anchorageProlonged neurogenesisMammalian cerebral cortexPrimary ciliaApical neural progenitorsCell membraneFraction of cellsNeural progenitorsStem cellsCerebral neurogenesisApical segmentsDevelopment of ciliaNuclear translocationMicrotubule organizing centerNeurogenesisCellsMacaque monkeysSpecies-specific differencesCortexBasal bodies
2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrus
2000
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar T, Wang F, Schwartz M, Rakic P. Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. Journal Of Neuroscience 2000, 20: 5764-5774. PMID: 10908617, PMCID: PMC3823557, DOI: 10.1523/jneurosci.20-15-05764.2000.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAntimetabolitesBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCerebral VentriclesClone CellsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFetusGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGlutamic AcidKainic AcidMiceMice, Inbred ICRMuscimolNeocortexNeuronsOrgan Culture TechniquesStem CellsConceptsVentricular zoneNeural progenitor populationsNeural progenitor proliferationSubventricular zoneProgenitor populationsCell cycleProgenitor cloneProgenitor proliferationEmbryonic cerebrumNeocortical growthProliferationDifferential responsivenessRecent studiesBromodeoxyuridine uptakeDifferential modulationOrganotypic slice culturesClassical neurotransmitters GABAOpposite effectNeurotransmitter GABARelative contributionClonesDisparate effectsRegulationSlice culturesSpecific GABARadial Unit Hypothesis of Neocortical Expansion
Rakic P. Radial Unit Hypothesis of Neocortical Expansion. Novartis Foundation Symposia 2000, 228: 30-45. PMID: 10929315, DOI: 10.1002/0470846631.ch3.Peer-Reviewed Original ResearchConceptsRadial unit hypothesisSpecies-specific sizeFamily of genesMutations of genesVentricular zoneMammalian evolutionFounder cellsNatural selectionRegulatory genesCell divisionMorphoregulatory moleculesPostmitotic cellsTransgenic animalsCortical plateCell deathNeocortical expansionGenesBasic organizationGlial scaffoldingColumnar unitsCortical cellsCerebral cortexCellsCortical developmentSynaptic connections
1998
Changes in cell-cycle kinetics during the development and evolution of primate neocortex
Kornack D, Rakic P. Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1242-1246. PMID: 9448316, PMCID: PMC18732, DOI: 10.1073/pnas.95.3.1242.Peer-Reviewed Original ResearchConceptsCell divisionCell division cycleCell cycle kineticsProgenitor cell divisionCell cycle lengthCell cycle durationEvolutionary modificationsEvolutionary expansionCerebral ventricular zoneDevelopmental basisCell productionPrimate neocortexS-phase labelingAnthropoid primatesProgenitor cellsFetal rhesus monkeysNeurogenetic periodVentricular zoneNeocortical sizeCortical cellsNeurogenesisCortical developmentMonkey cortexTotal roundsCortical layers
1995
Radial and horizontal deployment of clonally related cells in the primate neocortex: Relationship to distinct mitotic lineages
Kornack D, Rakic P. Radial and horizontal deployment of clonally related cells in the primate neocortex: Relationship to distinct mitotic lineages. Neuron 1995, 15: 311-321. PMID: 7646888, DOI: 10.1016/0896-6273(95)90036-5.Peer-Reviewed Original Research
1983
Early divergence and changing proportions of neuronal and glial precursor cells in the primate cerebral ventricular zone
Levitt P, Cooper M, Rakic P. Early divergence and changing proportions of neuronal and glial precursor cells in the primate cerebral ventricular zone. Developmental Biology 1983, 96: 472-484. PMID: 6339301, DOI: 10.1016/0012-1606(83)90184-7.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinVentricular zoneRhesus monkey fetusesPrecursor cellsFibrillary acidic proteinGFA-positive cellsCerebral ventricular zoneGlial precursor cellsNeuronal precursor cellsMonkey fetusesGestational periodProliferative ventricular zoneOccipital lobePrimate brainImmunocytochemical stainingAcidic proteinMitotic figuresCellular compositionEmbryonic ageCellsElectron microscopic analysisEarly divergenceFetusesPresent resultsNeurons
1982
The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey
Levitt P, Rakic P. The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey. Brain Research 1982, 4: 35-57. DOI: 10.1016/0165-3806(82)90095-5.Peer-Reviewed Original ResearchRaphe nucleusMA neuronsLocus coeruleusMonoamine neuronsSubstantia nigraRhesus monkeysPostnatal rhesus monkeysMajority of neuronsVentral tegmental areaProliferation of neuronsSeries of fetusesSN neuronsRaphe magnusBrain stemTegmental areaRaphe dorsalisGestational periodSynaptic targetsMedial partVentricular zoneLateral portionNeuronsFinal mitosisEmbryonic dayMonkeysThe time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey.
Levitt P, Rakic P. The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey. Brain Research 1982, 256: 35-57. PMID: 7093728, DOI: 10.1016/0165-3806(82)90095-5.Peer-Reviewed Original ResearchConceptsRaphe nucleusMA neuronsLocus coeruleusMonoamine neuronsSubstantia nigraRhesus monkeysPostnatal rhesus monkeysMajority of neuronsVentral tegmental areaProliferation of neuronsSeries of fetusesSN neuronsRaphe magnusBrain stemTegmental areaRaphe dorsalisGestational periodSynaptic targetsMedial partVentricular zoneLateral portionNeuronsFinal mitosisEmbryonic dayMonkeys
1981
The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey
Nowakowski R, Rakic P. The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey. The Journal Of Comparative Neurology 1981, 196: 129-154. PMID: 7204662, DOI: 10.1002/cne.901960110.Peer-Reviewed Original ResearchConceptsMicrometers/daySite of originVentricular zoneDentate gyrusHippocampal regionParahippocampal formationRhesus monkeysLateral cerebral ventricleMajority of neuronsLamina principalis externaDistinct cytoarchitectonic areasCerebral ventricleCortical plateSubventricular zoneAdjacent neocortexHippocampal formationMedial wallCytoarchitectonic areasNeuronsAnalysis of specimensThymidine autoradiographyProliferative zoneCell migrationGyrusLonger intervalsCoexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis
Levitt P, Cooper M, Rakic P. Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis. Journal Of Neuroscience 1981, 1: 27-39. PMID: 7050307, PMCID: PMC6564162, DOI: 10.1523/jneurosci.01-01-00027.1981.Peer-Reviewed Original ResearchConceptsGlial fibrillary acid proteinLast cell divisionCell divisionRadial glial cellsNeuronal cell lineAcid proteinCerebral ventricular zoneEmbryonic day 80Proliferative zoneGlial precursor cellsMitotic cycleCell typesPeak of neurogenesisPrecursor cellsCell linesVentricular zoneElectron microscopic levelFetal monkeysProliferative cellsGlial cellsSubventricular zoneOccipital lobePhenotypic expressionCytological compositionDistinct classes
1977
Genesis of the dorsal lateral geniculate nucleus in the rhesus monkey: Site and time of origin, kinetics of proliferation, routes of migration and pattern of distribution of neurons
Rakic P. Genesis of the dorsal lateral geniculate nucleus in the rhesus monkey: Site and time of origin, kinetics of proliferation, routes of migration and pattern of distribution of neurons. The Journal Of Comparative Neurology 1977, 176: 23-52. PMID: 409739, DOI: 10.1002/cne.901760103.Peer-Reviewed Original ResearchConceptsLateral geniculate bodyH3-TdRAnalysis of embryosExamination of embryosLast cell divisionGeneration of neuronsCell divisionCellular fasciclesPostmitotic cellsThird ventricleTime of originRoute of migrationPattern of distributionRhesus monkeysDorsal lateral geniculate bodyPrecursor neuronsDorsal lateral geniculate nucleusKinetics of proliferationEarly postnatal daysLateral geniculate nucleusVentricular zoneGerminal zoneProliferative unitsMonths of gestationEmbryos
1975
1 Timing of Major Ontogenetic Events in the Visual Cortex of the Rhesus Monkey
RAKIC P. 1 Timing of Major Ontogenetic Events in the Visual Cortex of the Rhesus Monkey. UCLA Forum In Medical Sciences 1975, 3-40. PMID: 812226, DOI: 10.1016/b978-0-12-139050-1.50008-2.Peer-Reviewed Original ResearchConceptsCortical plateMonkey visual cortexYoung neuronsVisual cortexSubventricular zoneVentricular cellsRadial glial guidesEarly postnatal stagesNumerous gliaLayer VSubventricular cellsMost neuronsLayer VILayer IVGlial guidesLayer IIICerebral surfaceVentricular zoneCell originCortical formationRhesus monkeysCell bodiesNeuronsPostnatal stagesCortex