1999
Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptorsProcessing of the Notch Ligand Delta by the Metalloprotease Kuzbanian
Qi H, Rand M, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S. Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian. Science 1999, 283: 91-94. PMID: 9872749, DOI: 10.1126/science.283.5398.91.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell LineCells, CulturedDisintegrinsDrosophilaDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsLigandsMaleMembrane ProteinsMetalloendopeptidasesMolecular Sequence DataMutationNeuronsProtein Processing, Post-TranslationalReceptors, NotchSignal TransductionTransfectionConceptsLigand DeltaMetalloprotease KuzbanianCell fate determinationNotch ligand DeltaFate determinationNotch proteinsTransmembrane ligandsNotch activityProcessing eventsExtracellular fragmentGenetic analysisNotch ligandsSurface receptorsKuzbanianAdjacent cellsSoluble formBroad spectrumNotchSignalingProteinLigandsCellsFragmentsVivoReceptors
1998
Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations
Komuro H, Rakic P. Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations. Developmental Neurobiology 1998, 37: 110-130. PMID: 9777736, DOI: 10.1002/(sici)1097-4695(199810)37:1<110::aid-neu9>3.0.co;2-c.Peer-Reviewed Original ResearchConceptsGranule cellsNeurotransmitter receptorsGranule cell movementN-methyl-D-aspartate (NMDA) subtypeN-type Ca2Different cortical layersIon channelsAcute cerebellar slicesFrequency of Ca2Local cellular milieuPhase of Ca2Position-specific changesVoltage-gated ion channelsGlutamate receptorsSpecific ion channelsCerebellar slicesIntracellular Ca2Transient Ca2Cortical layersReceptor activityNeuronal migrationReceptorsPlasmalemmal surfaceLocal environmental cuesCell migration
1996
Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex.
Mrzljak L, Levey A, Rakic P. Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7337-7340. PMID: 8692994, PMCID: PMC38985, DOI: 10.1073/pnas.93.14.7337.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusGeniculate nucleusVisual cortexMacaque monkey visual cortexM2 muscarinic acetylcholine receptorM2 muscarinic receptorsM2 receptor proteinMuscarinic acetylcholine receptorsMonkey visual cortexPrimate visual cortexM2 receptorsCerebral cortexMuscarinic receptorsExcitatory neurotransmissionParvocellular layersLayers IIAcetylcholine receptorsSynaptic circuitsNeuronal channelsParvocellular channelsParvocellular pathwayCortexSelective expressionReceptors
1994
Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration
Rakic P, Cameron R, Komuro H. Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration. Current Opinion In Neurobiology 1994, 4: 63-69. PMID: 8173327, DOI: 10.1016/0959-4388(94)90033-7.Peer-Reviewed Original ResearchConceptsCell motilityDiverse cellular mechanismsMultiple molecular eventsSpecific ion channelsTransmembrane signalingExtracellular substratesMigration of neuronsMolecular eventsSecond messengerMolecular componentsIndividual molecular componentsIon channelsCellular mechanismsNeuronal migrationRecognition receptorsAdhesive interactionsAdhesion moleculesMultiple adhesion moleculesFinal destinationRecent studiesMotilityReceptorsSignalingMessengerMigration
1993
Modulation of Neuronal Migration by NMDA Receptors
Komuro H, Rakic P. Modulation of Neuronal Migration by NMDA Receptors. Science 1993, 260: 95-97. PMID: 8096653, DOI: 10.1126/science.8096653.Peer-Reviewed Original ResearchConceptsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeEndogenous extracellular glutamateCell migrationNMDA receptor activityElimination of synapsesApplication of glycineSynaptic contactsSlice preparationExtracellular glutamateGlutamate receptorsSpecific antagonistGranule cellsReceptor activityNeuronal migrationNeuronal differentiationReceptorsMouse cerebellumEarly roleBlockadeAntagonistCerebellumSubtypesNeuronsBrain
1992
Scheduling of Monoaminergic Neurotransmitter Receptor Expression in the Primate Neocortex during Postnatal Development
Lidow M, Rakic P. Scheduling of Monoaminergic Neurotransmitter Receptor Expression in the Primate Neocortex during Postnatal Development. Cerebral Cortex 1992, 2: 401-416. PMID: 1330122, DOI: 10.1093/cercor/2.5.401.Peer-Reviewed Original ResearchConceptsMonoaminergic receptorsCortical layersReceptor densityCytoarchitectonic areasPostnatal developmentNeurotransmitter receptor expressionSuperficial cortical layersMonths of ageTime of pubertyCerebral cortexCortical maturationPostnatal monthReceptor expressionPrimary motorPrimate neocortexVisual cortexRhesus monkeysFourth monthReceptorsMonthsReceptor sitesCortexDevelopmental changesDevelopmental courseTransient overproduction
1991
Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.
Lidow M, Goldman-Rakic P, Rakic P. Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 10218-10221. PMID: 1658799, PMCID: PMC52899, DOI: 10.1073/pnas.88.22.10218.Peer-Reviewed Original Research
1990
Autoradiographic comparison of D1-specific binding of [3H]SCH39166 and SCH23390 in the primate cerebral cortex
Lidow M, Goldman-Rakic P, Rakic P, Gallager D. Autoradiographic comparison of D1-specific binding of [3H]SCH39166 and SCH23390 in the primate cerebral cortex. Brain Research 1990, 537: 349-354. PMID: 2085785, DOI: 10.1016/0006-8993(90)90384-n.Peer-Reviewed Original ResearchConceptsPrimate cerebral cortexCis-flupentixolCerebral cortexNovel dopamine D1 receptor antagonistDopamine D1 receptor antagonistD1 receptor antagonistSpecific bindingD1 receptor subtypeMicroM SCH23390Receptor antagonistReceptor subtypesAutoradiographic comparisonOccipital cortexLaminar patternQuantitative autoradiographySCH23390CortexRadioligandHigh affinityNon-specific bindingAntagonistSCH39166AgentsSubtypesReceptors
1989
Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride.
Lidow M, Goldman-Rakic P, Rakic P, Innis R. Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 6412-6416. PMID: 2548214, PMCID: PMC297850, DOI: 10.1073/pnas.86.16.6412.Peer-Reviewed Original ResearchConceptsDopamine D2 receptorsD2 receptorsD2 sitesDopamine D1 receptorsNeostriatum of ratsD2-selective antagonistRostral-caudal gradientCerebral cortexDopaminergic innervationD1 receptorsDopamine levelsDopamine receptorsPharmacological characterizationRat cortexSelective antagonistOccipital cortexPharmacological profileCognitive functionCortexReceptorsNeostriatumApparent involvementPresent studySaturable mannerMonkeysDistribution of major neurotransmitter receptors in the motor and somatosensory cortex of the rhesus monkey
Lidow M, Goldman-Rakic P, Gallager D, Geschwind D, Rakic P. Distribution of major neurotransmitter receptors in the motor and somatosensory cortex of the rhesus monkey. Neuroscience 1989, 32: 609-627. PMID: 2557559, DOI: 10.1016/0306-4522(89)90283-2.Peer-Reviewed Original ResearchConceptsMotor cortexSomatosensory cortexRhesus monkeysNeurotransmitter receptorsMajor neurotransmitter receptorsQuantitative autoradiographic techniqueAdult rhesus monkeysReceptor autoradiographyLaminar distributionReceptor subtypesMotor areaBenzodiazepine receptorsLayer IIIClassical histological techniquesLayer ID2 dopaminergicCortexAutoradiographic techniquesBeta 1Same receptorAlpha 1Alpha 2Different receptorsReceptorsCoextensive distribution
1988
Quantitative autoradiography of major neurotransmitter receptors in the monkey striate and extrastriate cortex
Rakic P, Goldman-Rakic P, Gallager D. Quantitative autoradiography of major neurotransmitter receptors in the monkey striate and extrastriate cortex. Journal Of Neuroscience 1988, 8: 3670-3690. PMID: 2848104, PMCID: PMC6569589, DOI: 10.1523/jneurosci.08-10-03670.1988.Peer-Reviewed Original ResearchConceptsMajor neurotransmitter receptorsArea 17Neurotransmitter receptorsBmax valuesQuinuclidinyl benzilateCortical layersVisual cortical areasAdult rhesus monkeysExtrinsic afferentsCholinergic receptorsCell-packing densityQuantitative autoradiographyCortical areasLaminar patternSpecific laminaeMonkey striateAdult monkeysArea 18Cytoarchitectonic areasEndogenous neurotransmittersLayer IRhesus monkeysBenzilateAlpha 2Receptors