2024
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997. PMID: 39475571, DOI: 10.1126/scitranslmed.abo1997.Peer-Reviewed Original ResearchConceptsProteomic analysisAlzheimer's diseasePrefrontal cortexBrain cell typesGenetics of PDParkinson's diseaseCell-cell interactionsChaperone expressionSingle-nucleus transcriptomesExpressed genesTranscriptional changesPostmortem human brainPostmortem brain tissueDiseased brainSynaptic proteinsSingle-cellDown-regulationBrain cell populationsBrain regionsCell typesNeurodegenerative disordersLate-stage PDParkinson's disease brainsDisease etiologyNeuronal vulnerability
2013
Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression.
Gupta R, Maralani P, Chawla S, Gopal P, Mohan S. Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression. Journal Of Neurosurgery 2013, 120: 522-7. PMID: 24329022, DOI: 10.3171/2013.11.jns13980.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Bacterial AgentsCerebellar DiseasesC-Reactive ProteinDecompression, SurgicalHumansImage Processing, Computer-AssistedImmunohistochemistryInfluenza VaccinesLeukocytosisMagnetic Resonance ImagingMaleNeuroimagingNeurosurgical ProceduresPseudotumor CerebriTomography, X-Ray ComputedVaccinationVentriculostomyConceptsPseudotumoral hemicerebellitisSurgical decompressionBilateral cerebellar hemispheresSignificant mass effectAcute cerebellitisT2 hyperintensityCerebellar swellingPediatric populationRare presentationSurgical interventionElderly malesInflammatory processPial enhancementAdvanced neuroimagingCerebellar hemisphereNeuroimaging findingsMR perfusionHemicerebellitisMR spectroscopyMass effectCerebellitisDecompressionMagnetic resonance