Differential long term effects of early diisopropylfluorophosphate exposure in Balb/C and C57Bl/J6 mice
Lin T, Duek O, Dori A, Kofman O. Differential long term effects of early diisopropylfluorophosphate exposure in Balb/C and C57Bl/J6 mice. International Journal Of Developmental Neuroscience 2011, 30: 113-120. PMID: 22197972, DOI: 10.1016/j.ijdevneu.2011.12.004.Peer-Reviewed Original ResearchConceptsLong-term effectsSwim testIrreversible acetylcholinesterase inhibitor diisopropylfluorophosphateBALB/c miceBALB/c strainPostnatal day 14BALB/cDifferential long-term effectsSub-toxic dosePostnatal administrationC miceMore immobilityDay 14Anxiety behaviorDFP pretreatmentC57BL/6J strainSweet preferenceConsecutive daysMouse strainsC strainMiceAge 3Term effectsFirst sessionSecond sessionAcetylcholinesterase inhibitor pretreatment alters stress-induced expression of acetylcholinesterase transcripts in the mouse brain
Dori A, Oriel S, Livneh U, Duek O, Lin T, Kofman O. Acetylcholinesterase inhibitor pretreatment alters stress-induced expression of acetylcholinesterase transcripts in the mouse brain. Neuroscience 2011, 183: 90-98. PMID: 21453753, DOI: 10.1016/j.neuroscience.2011.03.044.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAnalysis of VarianceAnimalsBrainCholinesterase InhibitorsDisease Models, AnimalDose-Response Relationship, DrugDrug Administration ScheduleFemaleGene Expression Regulation, EnzymologicIsoflurophateMaze LearningMiceMice, Inbred C57BLReaction TimeRNA, MessengerSpecies SpecificityStatistics as TopicStress, PsychologicalConceptsHomecage controlsC57BL/6 miceRestraint stressC57 BL/6 miceCD-1CD-1 miceSoluble splice variantAChE-R expressionExpression of AChEBL/6 miceTreatment groupsDays pretreatmentAnxiety behaviorMouse brainBrain regionsDFP pretreatmentStress-induced changesPrefrontal cortexMiceEffect of pretreatmentAmygdalaMazeTranscript expressionPretreatmentStress-induced expression