2024
Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT
Korem N, Duek O, Ben-Zion Z, Spiller T, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. Psychiatry Research Neuroimaging 2024, 343: 111864. PMID: 39111111, DOI: 10.1016/j.pscychresns.2024.111864.Peer-Reviewed Original ResearchReduced resting-state functional connectivityPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional connectivityPost-treatment changesReducing PTSD symptom severityFollow-up changesResting-state functional connectivityIntensive exposure therapyExposure-based psychotherapyVentromedial prefrontal cortexPTSD symptom severityReduced structural connectivityFunctional connectivity patternsPost-treatmentWhite matter integrityPrefrontal cortexExposure therapyPTSD symptomsStress disorderSymptom severityUncinate fasciculusLimbic systemSecondary analysisAssociated with sustained changes
2011
Acetylcholinesterase inhibitor pretreatment alters stress-induced expression of acetylcholinesterase transcripts in the mouse brain
Dori A, Oriel S, Livneh U, Duek O, Lin T, Kofman O. Acetylcholinesterase inhibitor pretreatment alters stress-induced expression of acetylcholinesterase transcripts in the mouse brain. Neuroscience 2011, 183: 90-98. PMID: 21453753, DOI: 10.1016/j.neuroscience.2011.03.044.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAnalysis of VarianceAnimalsBrainCholinesterase InhibitorsDisease Models, AnimalDose-Response Relationship, DrugDrug Administration ScheduleFemaleGene Expression Regulation, EnzymologicIsoflurophateMaze LearningMiceMice, Inbred C57BLReaction TimeRNA, MessengerSpecies SpecificityStatistics as TopicStress, PsychologicalConceptsHomecage controlsC57BL/6 miceRestraint stressC57 BL/6 miceCD-1CD-1 miceSoluble splice variantAChE-R expressionExpression of AChEBL/6 miceTreatment groupsDays pretreatmentAnxiety behaviorMouse brainBrain regionsDFP pretreatmentStress-induced changesPrefrontal cortexMiceEffect of pretreatmentAmygdalaMazeTranscript expressionPretreatmentStress-induced expression