2024
Clinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia.
Labarinas S, Norbisrath K, Johnson D, Meliones J, Greenleaf C, Salazar J, Karam O. Clinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia. Perfusion 2024, 2676591241247981. PMID: 38626382, DOI: 10.1177/02676591241247981.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationExtracorporeal membrane oxygenation daysCritically ill childrenSevere thrombocytopeniaPlatelet countPlatelet transfusionsMembrane oxygenationIll childrenMortality rateDuration of extracorporeal membrane oxygenationAssociated with in-hospital mortality ratesExtracorporeal membrane oxygenation durationSingle-center retrospective studyPlatelet transfusion strategyFrequent platelet transfusionsIn-hospital mortality rateAssociated with bleedingTransfusion strategyAssociated with higher proportionsMedian weightMulticenter studyRetrospective studyClinical outcomesOn-ECMOThrombocytopenia
2023
Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis
Aldairi N, Al Ali A, Alabdulqader M, Al Jeraisy M, Cyrus J, Karam O. Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis. Cureus 2023, 15: e39967. PMID: 37416033, PMCID: PMC10320736, DOI: 10.7759/cureus.39967.Peer-Reviewed Original ResearchContinuous renal replacement therapyExtracorporeal membrane oxygenationMolecular adsorbent recirculating systemRenal replacement therapyHypotensive eventsCircuit lifespanReplacement therapyAnticoagulation strategiesMeta-analysisThrombotic eventsExtracorporeal supportSystematic reviewAssociated with fewer bleeding eventsControl seriesProportion of bleedingMortality rateCritically ill childrenCritically ill patientsStatistically significant decreaseMultiple electronic databasesRandomized controlled trialsRisk of biasBleeding eventsMembrane oxygenationSupport modalitiesFirst nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO)
Cousin V, Rodriguez-Vigouroux R, Karam O, Rimensberger P, Posfay-Barbe K. First nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO). BMC Pediatrics 2023, 23: 89. PMID: 36823601, PMCID: PMC9948414, DOI: 10.1186/s12887-023-03908-3.Peer-Reviewed Original ResearchConceptsVA-ECMO supportPediatric intensive care unitMedian timeClinical signsMedian PICU LOSNosocomial infection occurrenceUrinary tract infectionVentilator-associated pneumoniaExtracorporeal membrane oxygenationIntensive care unitPaucity of dataPICU lengthPICU LOSRefractory shockVA-ECMOTract infectionsMedian ageMembrane oxygenationSternotomy infectionsCare unitRetrospective studySevere infectionsFirst infectionMortality rateInfection occurrenceCardiac manifestations of multisystem inflammatory syndrome of children after SARS-CoV-2 infection: a systematic review and meta-analysis.
Carmona C, Kuziez M, Freitas C, Cyrus J, Bain J, Karam O. Cardiac manifestations of multisystem inflammatory syndrome of children after SARS-CoV-2 infection: a systematic review and meta-analysis. Cardiology In The Young 2023, 33: 2319-2327. PMID: 36762563, DOI: 10.1017/s104795112300015x.Peer-Reviewed Original ResearchConceptsMultisystem inflammatory syndromeInflammatory syndromeCardiac manifestationsSystematic reviewSARS-CoV-2 infectionCommon cardiac manifestationVentricular systolic dysfunctionSARS-CoV-2 pandemicCoronary abnormalitiesSystolic dysfunctionHospital periodMembrane oxygenationOvid EmbasePatient outcomesOvid MEDLINEChild patientsLarge cohortAccurate prevalenceElectronic searchMortality rateLiterature databasesPrevalenceSyndromeFull textManifestations
2021
Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study
Nellis ME, Vasovic LV, Goel R, Karam O. Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study. Frontiers In Pediatrics 2021, 9: 673613. PMID: 34041211, PMCID: PMC8141845, DOI: 10.3389/fped.2021.673613.Peer-Reviewed Original ResearchHemostatic blood productsECMO daysPercent of childrenBlood productsMembrane oxygenationPediatric Health Information System Database StudyPediatric Health Information System databaseHealth Information System databaseUse of TXAHospital mortality rateRetrospective observational studyU.S. children's hospitalsExtracorporeal membrane oxygenationMedian ageChildren's HospitalMedian lengthHemostatic measuresInformation System databaseObservational studyECMODatabase studyHigh riskMortality rateHemostatic agentsFactor VIIa
2020
Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis
Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion 2020, 36: 501-512. PMID: 32862767, PMCID: PMC8216320, DOI: 10.1177/0267659120952982.Peer-Reviewed Original ResearchConceptsAnticoagulation strategiesMortality rateThrombotic eventsObservational studySystematic reviewProportion of bleedingType of ECMOExtracorporeal membrane oxygenationMultiple electronic databasesLower mortality rateMembrane oxygenationPatientsElectronic databasesECMOThrombosisSignificant differencesXaBleedingReviewMortalityStudy
2018
Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support
De Mul A, Nguyen DA, Doell C, Perez MH, Cannizzaro V, Karam O. Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support. Journal Of Pediatric Intensive Care 2018, 08: 057-063. PMID: 31093456, PMCID: PMC6517051, DOI: 10.1055/s-0038-1667012.Peer-Reviewed Original ResearchExtracorporeal life supportECLS initiationCPR durationClinical outcomesCardiopulmonary resuscitationPediatric intensive care unitLife supportReceiver-operating characteristic curveIntensive care unitPositive predictive valueActive resuscitationMedian agePrognostic factorsCare unitCardiac patientsPrognostic evaluationRetrospective analysisMortality ratePredictive valueSurvival ratePatientsStudy settingMortalityECPRCharacteristic curve
2016
Molecular Adsorbent Recirculating System (MARS™ en réanimation pédiatrique
Hagerman A, Karam O. Molecular Adsorbent Recirculating System (MARS™ en réanimation pédiatrique. Médecine Intensive Réanimation 2016, 25: 239-245. DOI: 10.1007/s13546-015-1162-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMolecular adsorbent recirculating systemHigh-flow hemofiltrationPediatric liver failureLife-threatening conditionCase-control studyLiver failureMortality rateControl studyLiver supportAppropriate timingRecirculating systemTreatmentAdultsSignificant improvementChildrenCurrent informationMorbidityPatientsHemofiltrationMortalityTrials