2024
Physical space of thirty pediatric intensive care units in the United States of America: a national survey
Karam O, Ahmed A, Bizzarro M, Bogue C, Giuliano J, Collaborative P, Al-Subu A, Bateman S, Berning E, Brown K, Bulut Y, Cheifetz I, Chegondi M, Cholette J, Cowl A, Ceneviva G, Gehlbach J, Hobson M, Kudchadkar S, Labarinas S, Louis C, Miller M, Marinello M, Malone M, Nair A, Nishisaki A, Lowrie L, Rehder K, Rozenfeld R, Schneider J, Sequeira J, Shein S, Stalets E, Taylor J, Yager P. Physical space of thirty pediatric intensive care units in the United States of America: a national survey. Frontiers In Pediatrics 2024, 12: 1473805. PMID: 39359742, PMCID: PMC11445063, DOI: 10.3389/fped.2024.1473805.Peer-Reviewed Original ResearchRoom sizePediatric intensive care unitPhysical spaceConstruction of hospitalsIntensive care unitBuilding yearDesign practiceCare unitBuildings dateRoom designPrivate bathroomsOccupancy rateDouble roomRenovationBathroomCompliant unitsRoom characteristicsAmenitiesDesignConstructionIntermediate care unitCardiac ICUClinical outcomesInterquartile rangeUnit types
2023
Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU
Greenfield K, Karam O, O'Meara A. Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU. Journal Of Pediatric Intensive Care 2023 DOI: 10.1055/s-0043-1770081.Peer-Reviewed Original ResearchPediatric intensive care unitDevelopment of deliriumAssociated with deliriumCornell Assessment of Pediatric DeliriumPediatric deliriumPediatric intensive care unit patientsIntensive care unitEtiology of deliriumModifiable risk factorsNo significant associationPresence of deliriumTreatment strategiesCare unitIndividual patientsRisk factorsCritical illnessStudy daysPatientsOpiate infusionsSignificant associationCornell AssessmentYounger ageDelirium prevalenceDeliriumNeurological diagnosisFirst nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO)
Cousin V, Rodriguez-Vigouroux R, Karam O, Rimensberger P, Posfay-Barbe K. First nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO). BMC Pediatrics 2023, 23: 89. PMID: 36823601, PMCID: PMC9948414, DOI: 10.1186/s12887-023-03908-3.Peer-Reviewed Original ResearchConceptsVA-ECMO supportPediatric intensive care unitMedian timeClinical signsMedian PICU LOSNosocomial infection occurrenceUrinary tract infectionVentilator-associated pneumoniaExtracorporeal membrane oxygenationIntensive care unitPaucity of dataPICU lengthPICU LOSRefractory shockVA-ECMOTract infectionsMedian ageMembrane oxygenationSternotomy infectionsCare unitRetrospective studySevere infectionsFirst infectionMortality rateInfection occurrence
2022
Effect of Platelet Transfusions on Extracorporeal Life Support Oxygenator’s Function
Chegondi M, Vijayakumar N, Badheka A, Karam O. Effect of Platelet Transfusions on Extracorporeal Life Support Oxygenator’s Function. Frontiers In Pediatrics 2022, 10: 826477. PMID: 35321010, PMCID: PMC8936087, DOI: 10.3389/fped.2022.826477.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationPediatric intensive care unitPlatelet transfusionsOxygenator functionECMO supportVeno-arterial extracorporeal membrane oxygenationOnly independent factorSubgroup of patientsIntensive care unitAnticoagulation strategiesCommon complicationMembrane oxygenationCare unitRetrospective studyMain complicationsLowest quartileTransfusionIndependent factorsMmHgECMO oxygenatorROC curveComplicationsPatientsChildrenRegression models
2021
Airway microbiome dynamics and relationship to ventilator‐associated infection in intubated pediatric patients
Tarquinio KM, Karsies T, Shein SL, Beardsley A, Khemani R, Schwarz A, Smith L, Flori H, Karam O, Cao Q, Haider Z, Smirnova E, Serrano MG, Buck GA, Willson DF. Airway microbiome dynamics and relationship to ventilator‐associated infection in intubated pediatric patients. Pediatric Pulmonology 2021, 57: 508-518. PMID: 34811963, PMCID: PMC8809006, DOI: 10.1002/ppul.25769.Peer-Reviewed Original ResearchConceptsVentilator-associated infectionDays of intubationAirway microbiomeSerial tracheal aspirate samplesPediatric intensive care unitIntensive care unitIntubated pediatric patientsTracheal aspirate samplesTracheal microbiomePediatric patientsCare unitClinical parametersIntubation periodClinical variablesAntibiotic treatmentVentilated subjectsAspirate samplesInfection scoreMedian numberSubject demographicsPorphyromonadaceae familyMicrobiome patternsIntubationVeillonella atypicaPatientsAvailability and Quality of Grief and Bereavement Care in Pediatric Intensive Care Units Around the World, Opportunities for Improvement
Grunauer M, Mikesell C, Bustamante G, Aronowitz D, Zambrano K, Icaza-Freire A, Gavilanes A, Barrera R, Group T, González J, López-Herce J, Rossetti E, Fabrizio C, Karam O, Saint-Faust M, Biban P, Carlassara S, von Dessauer B, Ordenes N, Urízar F, A A, Canarie M, Miller K, Irazuzta J, Tawfik D, Tucker E, Shilkofski N, Wenchao W, Yuxia Z, See L, Priscilla, Tekin R, Aktar F, Düzkaya D, Dursun O, Ongun E, Yilmaz R, Yildizdas D, Tekgüç H, Sazonov V, Tsoy T, Sazonov V, Saparov A, Sazonov V, Kalmbakh E, Grunauer M, Quiñones E, Eguiguren L, Briones K, Tovilla Y, Gómez S, Torres S, Cobarrubias P, Dmytriiev D, Martínez A, Guzaman G, Sanabria R, Krupanandan R, Ramachandran B, Choraria N, Patel J, Pooni P, Gill K, Appiah J, Heye T, Argaw R, Demtse A, Admasu I. Availability and Quality of Grief and Bereavement Care in Pediatric Intensive Care Units Around the World, Opportunities for Improvement. Frontiers In Pediatrics 2021, 9: 742916. PMID: 34869100, PMCID: PMC8634722, DOI: 10.3389/fped.2021.742916.Peer-Reviewed Original ResearchPediatric intensive care unitHealth care professionalsIntensive care unitHigh-income countriesCare unitUpper middle-income countriesBereavement careFulfillment scoresPalliative care consultation servicePediatric palliative careTrajectory of illnessProspective survey studyAge/genderTime of deathUnit infrastructurePatient characteristicsMiddle-income countriesMultidisciplinary carePalliative careIll childrenCare professionalsDirect careChild deathsCountry income levelLimited patient dataPain Assessment and Management in Pediatric Intensive Care Units Around the World, an International, Multicenter Study
Grunauer M, Mikesell C, Bustamante G, Cobo G, Sánchez S, Román A, Icaza-Freire A, Gavilanes A, Wang N, Group T, González J, López-Herce J, Rossetti E, Fabrizio C, Karam O, Saint-Faust M, Biban P, Carlassara S, von Dessauer B, Ordenes N, Urízar F, A A, Canarie M, Miller K, Irazuzta J, Chiriboga N, Tawfik D, Sourkes B, Wang N, Vongsachang H, Tucker E, Shilkofski N, Wang 王, Wenchao R, Yuxia Z, See L, Priscilla, Tekin R, Aktar F, Düzkaya D, Dursun O, Ongun E, Yilmaz R, Yildizdas D, Tekgüç H, Sazonov V, Tsoy T, Sazonov V, Saparov A, Sazonov V, Kalmbakh E, Grunauer M, Eguiguren L, Claudette K, Tovilla Y, Gómez S, Torres S, Cobarrubias P, Dmytriiev D, Martínez A, Guzaman G, Sanabria R, Krupanandan R, Ramachandran B, Choraria N, Patel J, Pooni P, Gill K, Appiah J, Anokye K, Heye T, Argaw R, Demtse A, Admasu I. Pain Assessment and Management in Pediatric Intensive Care Units Around the World, an International, Multicenter Study. Frontiers In Pediatrics 2021, 9: 746489. PMID: 34778135, PMCID: PMC8581242, DOI: 10.3389/fped.2021.746489.Peer-Reviewed Original ResearchPediatric intensive care unitIntensive care unitCare unitPain assessmentMulticenter cross-sectional observational studyCross-sectional observational studyPain management expertsPain management scoresPalliative care recommendationsManagement of painIncome countriesPain reliefMulticenter studyCare recommendationsObservational studyHigh-income countriesPainRoutine assessmentMedical doctorsAdequate assessmentManagement scoresAssessmentLack of resourcesRural areasSignificant trendEpidemiology of Bleeding in Critically Ill Children
Sequeira J, Nellis ME, Karam O. Epidemiology of Bleeding in Critically Ill Children. Frontiers In Pediatrics 2021, 9: 699991. PMID: 34422724, PMCID: PMC8371326, DOI: 10.3389/fped.2021.699991.Peer-Reviewed Original ResearchPediatric critical care unitRisk of mortalityCritical care unitsIll childrenCare unitClinical outcomesProspective observational cohort studyEpidemiology of BleedingPICU-free daysPercent of patientsVentilator-free daysDuration of surgeryObservational cohort studyCritically Ill ChildrenWorse clinical outcomesType of surgeryFurther multicenter studiesHigher severityCohort studyCritical illnessPediatric IndexSevere complicationsConsecutive patientsIll patientsMedian agePerformance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children
Chegondi M, Vijayakumar N, Billa R, Badheka A, Karam O. Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children. Journal Of Pediatric Intensive Care 2021, 12: 228-234. PMID: 37565022, PMCID: PMC10411082, DOI: 10.1055/s-0041-1731434.Peer-Reviewed Original ResearchPlatelet mass indexPediatric intensive care unitSeptic shockPICU admissionMass indexPrognostic indicatorFl/Day 1Marker of severityRetrospective observational studyIntensive care unitCare unitPediatric sepsisObservational studyClinical valueDay 3SepsisCharacteristic curveFurther studiesAdmissionPMI valuesChildrenAUCSpecificityNonsurvivorsBleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation
Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Frontiers In Pediatrics 2021, 9: 611680. PMID: 33585373, PMCID: PMC7873638, DOI: 10.3389/fped.2021.611680.Peer-Reviewed Original Research
2020
Brighter Days May Be Ahead: Continuous Measurement of Pediatric Intensive Care Unit Light and Sound
Greenfield KD, Karam O, O'Meara A. Brighter Days May Be Ahead: Continuous Measurement of Pediatric Intensive Care Unit Light and Sound. Frontiers In Pediatrics 2020, 8: 590715. PMID: 33194924, PMCID: PMC7649178, DOI: 10.3389/fped.2020.590715.Peer-Reviewed Original ResearchPediatric intensive care unitCourse of admissionIll childrenTertiary care pediatric intensive care unitProspective observational cohort studyPost-intensive care syndromeObservational cohort studyIntensive care unitModifiable environmental factorsMedian illuminancePatients 0Cardiovascular supportCohort studyCare unitClinical effectsPatientsMedian light levelsSleep/AdmissionSound levelsMedian sound levelChildrenUnit lightHoursLevelsEffect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children
Nellis ME, Spinella PC, Tucci M, Stanworth SJ, Steiner ME, Cushing MM, Davis PJ, Karam O, The Pediatric Acute Lung Injury and Sepsis Investigators network P. Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children. Transfusion 2020, 60: 2849-2858. PMID: 32959409, PMCID: PMC8396066, DOI: 10.1111/trf.16094.Peer-Reviewed Original ResearchConceptsClinical outcomesIll childrenPLT transfusionsObservational point prevalence studyPediatric intensive care unitStorage ageSafety of plateletsFurther prospective evaluationPoint prevalence studyIntensive care unitImmune system dysfunctionFebrile transfusion reactionsDays of ageScreening weekCare unitProspective evaluationSystem dysfunctionTransfusion reactionsPlatelet changesTransfusionPLT countTransfusion efficacyAge groupsSecondary analysisSignificant associationAssociation Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass
Klee P, Rimensberger PC, Karam O. Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass. Frontiers In Pediatrics 2020, 8: 332. PMID: 32656170, PMCID: PMC7325592, DOI: 10.3389/fped.2020.00332.Peer-Reviewed Original ResearchPediatric critical care unitPICU admissionSystemic oxygen deliveryCardiopulmonary bypassCritical care unitsOxygen extractionBlood glucoseOxygen deliveryCardiac surgeryCare unitLow systemic oxygen deliveryObservational cohort studyDuration of bypassWorse clinical outcomesHigher oxygen extractionLogistic regression modelsCohort studyCardiac lesionsClinical outcomesSurrogate markerPyruvate ratioAdmissionHyperlactatemiaSame timepointsBypass
2018
Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support
De Mul A, Nguyen DA, Doell C, Perez MH, Cannizzaro V, Karam O. Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support. Journal Of Pediatric Intensive Care 2018, 08: 057-063. PMID: 31093456, PMCID: PMC6517051, DOI: 10.1055/s-0038-1667012.Peer-Reviewed Original ResearchExtracorporeal life supportECLS initiationCPR durationClinical outcomesCardiopulmonary resuscitationPediatric intensive care unitLife supportReceiver-operating characteristic curveIntensive care unitPositive predictive valueActive resuscitationMedian agePrognostic factorsCare unitCardiac patientsPrognostic evaluationRetrospective analysisMortality ratePredictive valueSurvival ratePatientsStudy settingMortalityECPRCharacteristic curve
2017
A Quantitative Pilot Study on Donation after Cardiac Death (DCD)
Zellweger A, Eckert P, Karam O, Cedraschi C, Moretti D, Majmou H, Carre D, Ludwig V, Gasche Y. A Quantitative Pilot Study on Donation after Cardiac Death (DCD). Transplantation 2017, 101: s21. DOI: 10.1097/01.tp.0000525002.75001.e9.Peer-Reviewed Original ResearchIntensive care unitLausanne University HospitalDCD programUniversity HospitalICU caregiversAdult intensive care unitsOrgan donationPilot studyDepartment of AnaesthesiologyGeneva University HospitalsBrain death criteriaTherapy withdrawalPalliative treatmentCardiac deathCare unitICU nursesPatient deathDCD proceduresICU personnelLife careLife-support decisionsICU professionalsQuantitative pilot studyOrgan shortageCare assistantsFactors influencing plasma transfusion practices in paediatric intensive care units around the world
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Tucci M, Leteurtre S, Stanworth SJ, investigators T. Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Vox Sanguinis 2017, 112: 140-149. PMID: 28176380, DOI: 10.1111/vox.12490.Peer-Reviewed Original ResearchConceptsPlasma transfusion practicesPlasma transfusionTransfusion practiceCoagulation testsPediatric intensive care unitInternational pediatric studiesLocal transfusion serviceAbnormal coagulation testsIntensive care unitEfficacy of transfusionSignificant relevant factorTransfusion policyTransfusion rateCare unitAppropriate indicationsPediatric studiesFrequent treatmentTransfusionResponse rateTransfusion servicesLocal investigatorsPatientsCenter characteristicsWide variationBleeding
2016
Potential Pediatric Organ Donors After Cardiac Death
Pregernig A, Karam O. Potential Pediatric Organ Donors After Cardiac Death. Transplantation Proceedings 2016, 48: 2588-2591. PMID: 27788786, DOI: 10.1016/j.transproceed.2016.06.049.Peer-Reviewed Original ResearchConceptsWithdrawal of careOrgan donorsAgonal timeMaximal resuscitationCardiac deathPediatric populationNeonatal intensive care unitOrgan donationBrain-dead childrenIntensive care unitOrgan donor poolTransplant waiting listPediatric organ donorPotential organ donorsOrgan donation programsMedical contraindicationsCare unitRetrospective studyDonor poolWaiting listDonation programDonor populationCareChildrenResuscitationAccuracy of Transcutaneous Carbon Dioxide Measurement in Premature Infants
Janaillac M, Labarinas S, Pfister RE, Karam O. Accuracy of Transcutaneous Carbon Dioxide Measurement in Premature Infants. Critical Care Research And Practice 2016, 2016: 8041967. PMID: 27375901, PMCID: PMC4916268, DOI: 10.1155/2016/8041967.Peer-Reviewed Original ResearchPremature infantsBlood partial pressureBlood pCO2 valuesGestational ageBlood PCO2Tertiary neonatal intensive care unitNeonatal intensive care unitConsecutive premature infantsRetrospective observational studyWeeks gestational ageIntensive care unitTranscutaneous carbon dioxide measurementsCare unitCerebral lesionsObservational studyTranscutaneous methodCarbon dioxide valuesInfantsR correlationsTcPCO2Transcutaneous valuesPCO2 valuesPearson r correlationsPCO2Carbon dioxide measurements
2015
Indications and Effects of Plasma Transfusions in Critically Ill Children
Karam O, Demaret P, Shefler A, Leteurtre S, Spinella PC, Stanworth SJ, Tucci M. Indications and Effects of Plasma Transfusions in Critically Ill Children. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1395-1402. PMID: 25859890, DOI: 10.1164/rccm.201503-0450oc.Peer-Reviewed Original ResearchConceptsInternational normalized ratioMedian international normalized ratioPlasma transfusionIll childrenCoagulation testsBaseline international normalized ratioPediatric intensive care patientsPediatric intensive care unitPartial thromboplastin time valuesCritically Ill ChildrenPoint prevalence studyIntensive care patientsIntensive care unitStrong evidence baseMinor bleedingPostoperative bleedingMost patientsPatient characteristicsTransfusion strategyCare patientsCare unitCritical bleedingNormalized ratioPrimary indicationTransfusion
2014
Transfusions de plasma en réanimation pédiatrique
Labarinas S, Arni D, Karam O. Transfusions de plasma en réanimation pédiatrique. Médecine Intensive Réanimation 2014, 23: 455-462. DOI: 10.1007/s13546-014-0900-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAbnormal coagulation testsPlasma transfusionCoagulation testsRed blood cell transfusionNon-bleeding patientsBlood cell transfusionIntensive care unitRecent epidemiological studiesCell transfusionIll adultsIll patientsCare unitRéanimation pédiatriqueFrequent treatmentObservational studyCurrent evidenceEpidemiological studiesTransfusionCoagulation factorsVolume replacementPatientsTreatmentMost expertsIndicationsBleeding