1989
The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study
Young R, Chen B, Petroff O, Gore J, Cowan B, Novotny E, Wong M, Zuckerman K. The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study. Pediatric Research 1989, 25: 27-31. PMID: 2919113, DOI: 10.1203/00006450-198901000-00006.Peer-Reviewed Original ResearchConceptsBrain lactateBrain high-energy phosphatesArrest of seizuresFlurothyl-induced seizuresCerebral blood flowNormalization of EEGEffects of diazepamVivo 31P nuclear magnetic resonance spectroscopyHigh-energy phosphatesElectrographic seizuresNeonatal seizuresNeonatal dogsPostictal periodBrain pHBaseline valuesBlood flowBrain phosphocreatineMetabolic recoveryProlonged elevationSeizuresSustained increaseVivo 31PRapid returnDiazepamEnergy phosphates
1987
In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure
Young R, Cowan B, Petroff O, Novotny E, Dunham S, Briggs R. In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure. Annals Of Neurology 1987, 22: 622-628. PMID: 3426168, DOI: 10.1002/ana.410220511.Peer-Reviewed Original ResearchConceptsNeonatal seizuresBrain energy stateBicuculline-induced seizuresBrain glucose concentrationsCerebral blood flowBeta-hydroxybutyrate levelsBrain metabolic stateVivo 31P nuclear magnetic resonance spectroscopyBrain alanineAdenosine triphosphate levelsNeonatal dogsPhosphocreatine levelsSignificant elevationBlood flowSeizuresMagnetic resonance spectroscopyBrain extractsVivo 31PHypoglycemiaAdverse effectsTriphosphate levelsGlucose concentrationGreater declineFurther deteriorationMetabolic state
1986
Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose
Behar K, Petroff O, Prichard J, Alger J, Shulman R. Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose. Magnetic Resonance In Medicine 1986, 3: 911-920. PMID: 2881185, DOI: 10.1002/mrm.1910030611.Peer-Reviewed Original ResearchHigh‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid
Petroff O, Yu R, Ogino T. High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid. Journal Of Neurochemistry 1986, 47: 1270-1276. PMID: 3746301, DOI: 10.1111/j.1471-4159.1986.tb00750.x.Peer-Reviewed Original Research