2020
An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability
Folkes OM, Báldi R, Kondev V, Marcus DJ, Hartley ND, Turner BD, Ayers JK, Baechle JJ, Misra MP, Altemus M, Grueter CA, Grueter BA, Patel S. An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability. Journal Of Clinical Investigation 2020, 130: 1728-1742. PMID: 31874107, PMCID: PMC7108917, DOI: 10.1172/jci131752.Peer-Reviewed Original ResearchConceptsInhibitory neurotransmissionModulation of excitatoryAutism spectrum disorderAdministration of JZL184Feed-forward inhibitionMonoacylglycerol lipase inhibitorsVivo optogenetic activationSI deficitsGlutamatergic activityWT miceGlutamatergic circuitsNAc neuronsOptogenetic activationNovel treatmentsSocial deficitsOptogenetic inhibitionNeuromodulatory mechanismsBrain circuitsCore symptomsLipase inhibitorASD pathophysiologyASD modelsJZL184NeurotransmissionDeficits
2017
Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior
Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ. Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior. Biological Psychiatry 2017, 84: 304-315. PMID: 29458998, PMCID: PMC6023784, DOI: 10.1016/j.biopsych.2017.11.036.Peer-Reviewed Original ResearchConceptsDirect pathway medium spiny neuronsMedium spiny neuronsDorsal striatumIndirect pathway medium spiny neuronsReceptor-expressing medium spiny neuronsStriatal direct pathwayAutism spectrum disorderDiacylglycerol lipase αConditional knockout miceSpectrum disorderGlutamatergic driveSpiny neuronsEndocannabinoid signalingRepetitive groomingSynaptic transmissionMouse modelRepetitive behaviorsKnockout miceExcessive groomingDopamine DBrain regionsStriatumVentral striatumBehavioral effectsTargeted deletion