2020
An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability
Folkes OM, Báldi R, Kondev V, Marcus DJ, Hartley ND, Turner BD, Ayers JK, Baechle JJ, Misra MP, Altemus M, Grueter CA, Grueter BA, Patel S. An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability. Journal Of Clinical Investigation 2020, 130: 1728-1742. PMID: 31874107, PMCID: PMC7108917, DOI: 10.1172/jci131752.Peer-Reviewed Original ResearchConceptsInhibitory neurotransmissionModulation of excitatoryAutism spectrum disorderAdministration of JZL184Feed-forward inhibitionMonoacylglycerol lipase inhibitorsVivo optogenetic activationSI deficitsGlutamatergic activityWT miceGlutamatergic circuitsNAc neuronsOptogenetic activationNovel treatmentsSocial deficitsOptogenetic inhibitionNeuromodulatory mechanismsBrain circuitsCore symptomsLipase inhibitorASD pathophysiologyASD modelsJZL184NeurotransmissionDeficits
2013
Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith–Lemli–Opitz syndrome
Korade Z, Folkes OM, Harrison FE. Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith–Lemli–Opitz syndrome. Pharmacology Biochemistry And Behavior 2013, 106: 101-108. PMID: 23541496, DOI: 10.1016/j.pbb.2013.03.007.Peer-Reviewed Original ResearchConceptsWild-type control miceMonths of ageControl miceHead-twitch responseSevere behavioral deficitsSocial dominance tube testSmith-LemliOpitz syndromeHET miceSerotonergic systemBehavioral deficitsSpectrum disorderBehavioral disturbancesMouse modelAgonist 1Behavioral testingUnderlying dysfunctionHuman patientsLocomotor activityNew treatmentsCholesterol synthesisMiceMolecular pathophysiologyUnfamiliar mouseDimethoxy-4