Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith–Lemli–Opitz syndrome
Korade Z, Folkes OM, Harrison FE. Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith–Lemli–Opitz syndrome. Pharmacology Biochemistry And Behavior 2013, 106: 101-108. PMID: 23541496, DOI: 10.1016/j.pbb.2013.03.007.Peer-Reviewed Original ResearchConceptsWild-type control miceMonths of ageControl miceHead-twitch responseSevere behavioral deficitsSocial dominance tube testSmith-LemliOpitz syndromeHET miceSerotonergic systemBehavioral deficitsSpectrum disorderBehavioral disturbancesMouse modelAgonist 1Behavioral testingUnderlying dysfunctionHuman patientsLocomotor activityNew treatmentsCholesterol synthesisMiceMolecular pathophysiologyUnfamiliar mouseDimethoxy-4