An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability
Folkes OM, Báldi R, Kondev V, Marcus DJ, Hartley ND, Turner BD, Ayers JK, Baechle JJ, Misra MP, Altemus M, Grueter CA, Grueter BA, Patel S. An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability. Journal Of Clinical Investigation 2020, 130: 1728-1742. PMID: 31874107, PMCID: PMC7108917, DOI: 10.1172/jci131752.Peer-Reviewed Original ResearchConceptsInhibitory neurotransmissionModulation of excitatoryAutism spectrum disorderAdministration of JZL184Feed-forward inhibitionMonoacylglycerol lipase inhibitorsVivo optogenetic activationSI deficitsGlutamatergic activityWT miceGlutamatergic circuitsNAc neuronsOptogenetic activationNovel treatmentsSocial deficitsOptogenetic inhibitionNeuromodulatory mechanismsBrain circuitsCore symptomsLipase inhibitorASD pathophysiologyASD modelsJZL184NeurotransmissionDeficits