Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo
Bermingham DP, Hardaway JA, Snarrenberg CL, Robinson SB, Folkes OM, Salimando GJ, Jinnah H, Blakely RD. Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo. Neurochemistry International 2016, 98: 122-128. PMID: 26850478, PMCID: PMC4969213, DOI: 10.1016/j.neuint.2016.01.008.Peer-Reviewed Original ResearchConceptsDAT-1Caenorhabditis elegansSwimming-Induced ParalysisNematode Caenorhabditis elegansGenetic mutationsPresynaptic DA transporterNovel genesHeterologous expressionDA releaseFunction mutationsGenetic modificationIon channelsElegansMutationsPresynaptic DA receptorsModulation of neurotransmissionGenesSWIPPhenotypeDA receptorsAcute blockadeDA transporterDA uptakeDA signalingExpression