2019
24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo
Verma A, Cohen DJ, Schwartz N, Muktipaty C, Koblinski JE, Boyan BD, Schwartz Z. 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. Biochimica Et Biophysica Acta (BBA) - General Subjects 2019, 1863: 1498-1512. PMID: 31125679, DOI: 10.1016/j.bbagen.2019.05.013.Peer-Reviewed Original ResearchConceptsEstrogen receptorMCF7 tumor growthBreast cancer patientsBreast cancer cell survivalBreast cancer xenograftsNarrow therapeutic windowMammary fat padDose-dependent increasePre-clinical studiesNull female miceMarker of invasionAnti-proliferative effectsBreast cancer cellsCell survivalCancer cell survivalTumor burdenAnti-tumorigenic propertiesVitamin DCancer patientsCancer xenograftsFemale miceHigh serumBreast cancerDihydroxyvitamin D3Therapeutic window
2016
Rapid steroid hormone actions via membrane receptors
Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica Et Biophysica Acta 2016, 1863: 2289-2298. PMID: 27288742, DOI: 10.1016/j.bbamcr.2016.06.004.Peer-Reviewed Original ResearchConceptsDNA-binding sitesPhosphoinositide-3 kinaseClassical steroid hormone receptorsMembrane-bound receptorsNumber of pathwaysDevelopmental functionsGene transcriptionSteroid hormone actionSteroid hormonesImpact tumorigenesisCell cycleCellular activitiesMembrane receptorsPhospholipase DSteroid hormone receptorsPhospholipase CReceptor counterpartsRapid steroidCancer cellsNovel receptorPathwayDihydroxy vitamin D3Cytosolic receptorHormone actionHormone receptors
2013
Role of ERα36 in membrane-associated signaling by estrogen
Chaudhri RA, Schwartz N, Elbaradie K, Schwartz Z, Boyan BD. Role of ERα36 in membrane-associated signaling by estrogen. Steroids 2013, 81: 74-80. PMID: 24252378, DOI: 10.1016/j.steroids.2013.10.020.Peer-Reviewed Original ResearchConceptsCell typesPlasma membraneAlternative splicing variantsRole of ERα36Non-genomic responsesDifferent cell typesMembrane-associated receptorsCancer cell typesPhosphorylation cascadeTranscription factorsProtein kinaseCellular developmentGene transcriptionApoptotic signalingSplicing variantsCellular responsesNon-classical receptorsNon-classical mechanismNuclear receptorsSimilar pathwaysCell proliferationSteroid hormonesNormal cellsEstrogen receptor αTraditional receptors