2023
Hydroxyapatite Use in Repair of Lateral Skull Base CSF Leaks Via Transmastoid Approach: When Does It Work?
Shah R, Kveton J, Schwartz N. Hydroxyapatite Use in Repair of Lateral Skull Base CSF Leaks Via Transmastoid Approach: When Does It Work? Otology & Neurotology 2023, 44: 804-808. PMID: 37550871, DOI: 10.1097/mao.0000000000003973.Peer-Reviewed Original ResearchConceptsCSF leak repairTransmastoid approachTertiary level care hospitalSkull Base Cerebrospinal Fluid LeaksLeak repairHydroxyapatite cementPrior smoking historyTrans-mastoid approachPatients 18 yearsRetrospective cohort studyRecurrence of symptomsVP shunt placementPatient demographic factorsBenign intracranial hypertensionSpontaneous CSF leaksCerebrospinal fluid leakFailure rateSkull base repairAverage defect sizeRepair cohortRecurrent symptomsAdjuvant treatmentFormer smokersSmoking historyCohort studyOver‐The‐Counter Hearing Aids: Trends in Information‐Seeking Behavior
Panth N, Shah R, Judson B, Schwartz N. Over‐The‐Counter Hearing Aids: Trends in Information‐Seeking Behavior. Otolaryngology 2023, 169: 1691-1693. PMID: 37365970, DOI: 10.1002/ohn.406.Peer-Reviewed Original Research
2021
Multifocal Skull Base Defects With Associated Spontaneous Cerebrospinal Fluid Leaks
Schwartz N, Brown KD, Sasaki-Adams D, Morgan SA, Zanation AM, Thorp BD, O’Connell B. Multifocal Skull Base Defects With Associated Spontaneous Cerebrospinal Fluid Leaks. Otology & Neurotology 2021, 42: e624-e628. PMID: 33416298, DOI: 10.1097/mao.0000000000003048.Peer-Reviewed Original ResearchConceptsSpontaneous CSF leaksSpontaneous cerebrospinal fluid leaksElevated intracranial pressureCerebrospinal fluid leakCSF leakSurgical repairSurgical outcomesIntracranial pressureFluid leakSkull basePatients 18 yearsPercent of patientsTertiary referral centerRetrospective case seriesBody mass indexCSF leak repairOverall success rateCSF leak patientsAfrican AmericansSkull base defectsLeak patientsReferral centerCase seriesClinical presentationMass index
2020
Audiologic Outcomes of Cochlear Implantation in Cochlear Malformations: A Comparative Analysis of Lateral Wall and Perimodiolar Electrode Arrays.
Schwartz N, Brown KD, Park LR. Audiologic Outcomes of Cochlear Implantation in Cochlear Malformations: A Comparative Analysis of Lateral Wall and Perimodiolar Electrode Arrays. Otology & Neurotology 2020, 41: e1201-e1206. PMID: 33433084, DOI: 10.1097/mao.0000000000002833.Peer-Reviewed Original ResearchConceptsCochlear malformationsCochlear implantationLateral wallCochlear implantsTertiary referral centerRetrospective case seriesCochlear nerve deficiencyInner ear malformationsPediatric cochlear implant recipientsType of malformationCochlear implant recipientsConsonant word scoresSpeech perception outcomesReferral centerAudiologic outcomesCase seriesOutcome advantageEar malformationsRecognition outcomesMAIN OUTCOMESpeech perception scoresImplant recipientsMalformationsPerimodiolar electrode arrayPerception outcomesMRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection
Schwartz N, Rooth MA, Dillon MT, O'Connell BP, Dedmon MM, Huang BY, Brown KD. MRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection. American Journal Of Otolaryngology 2020, 41: 102518. PMID: 32451290, DOI: 10.1016/j.amjoto.2020.102518.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCochlear ImplantationCochlear NerveCranial Nerve NeoplasmsFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMonitoring, PhysiologicNeuroma, AcousticOrgan Sparing TreatmentsPostoperative PeriodRetrospective StudiesVestibulocochlear NerveVestibulocochlear Nerve DiseasesConceptsInternal auditory canalConcurrent cochlear implantationVestibular schwannoma resectionIpsilateral internal auditory canalCerebellopontine angleSchwannoma resectionCochlear nerveCochlear implantationHead MRITranslabyrinthine vestibular schwannoma resectionCochlear implant magnetResidual tumor growthCI recipientsMagnetic resonance imaging (MRI) monitoringTranslabyrinthine excisionImplant magnetMRI surveillanceRetrospective reviewVS tumorsTumor recurrenceAuditory canalSerial monitoringCI magnetExcellent visualizationTumor growthLoss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma
Verma A, Schwartz N, Cohen DJ, Patel V, Nageris B, Bachar G, Boyan BD, Schwartz Z. Loss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma. Scientific Reports 2020, 10: 4227. PMID: 32144339, PMCID: PMC7060328, DOI: 10.1038/s41598-020-60675-2.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaERβ expressionCell carcinomaLaryngeal squamous cell carcinomaEstrogen receptor-dependent mechanismHigh ESR1 expressionClinical cancer stageCancer Genome AtlasImproved survivalTumor burdenPathological stageResponsive cancersCancer stageERα36 expressionHistopathological markersEstrogen receptorXenograft tumorsESR1 expressionTumor aggressionEpithelial samplesLSCCDependent mechanismGenome AtlasERα66Carcinoma
2019
Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer
Verma A, Schwartz N, Cohen DJ, Boyan BD, Schwartz Z. Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer. Steroids 2019, 152: 108498. PMID: 31539535, DOI: 10.1016/j.steroids.2019.108498.Peer-Reviewed Original ResearchConceptsSex hormone receptorsEstrogen receptorBreast cancerHormone receptorsCanonical estrogen receptorsAnti-estrogen therapyLoss of ERαSquamous cell carcinomaEstrogen receptor αHormone therapyPrognostic valueCell carcinomaPrognostic indicatorLaryngeal cancerPrognostic markerSex hormonesLSCC tumorsEstrogen signalingReceptor αTumor growthPathogenic markersEnhanced aggressionImportant modulatorERαCancer24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo
Verma A, Cohen DJ, Schwartz N, Muktipaty C, Koblinski JE, Boyan BD, Schwartz Z. 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. Biochimica Et Biophysica Acta (BBA) - General Subjects 2019, 1863: 1498-1512. PMID: 31125679, DOI: 10.1016/j.bbagen.2019.05.013.Peer-Reviewed Original ResearchConceptsEstrogen receptorMCF7 tumor growthBreast cancer patientsBreast cancer cell survivalBreast cancer xenograftsNarrow therapeutic windowMammary fat padDose-dependent increasePre-clinical studiesNull female miceMarker of invasionAnti-proliferative effectsBreast cancer cellsCell survivalCancer cell survivalTumor burdenAnti-tumorigenic propertiesVitamin DCancer patientsCancer xenograftsFemale miceHigh serumBreast cancerDihydroxyvitamin D3Therapeutic window
2017
Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomes
Schwartz N, Verma A, Muktipaty C, Bivens C, Schwartz Z, Boyan BD. Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomes. Steroids 2017, 142: 34-42. PMID: 29274403, DOI: 10.1016/j.steroids.2017.11.012.Peer-Reviewed Original ResearchConceptsLaryngeal cancerReceptor profileCancer cellsLaryngeal cancer patientsAnti-apoptotic effectsSteroid hormone receptorsClassical nuclear receptorsCancer cell linesClinical outcomesAnti-apoptotic potentialCancer patientsLaryngeal tumorsTreatment modalitiesSex hormonesClinical characterizationIndividual patientsEstrogen responsivenessHormone responsivenessDifferent cancer cellsCancerDifferent cancer cell linesHormone receptorsAdverse effectsReceptorsMembrane ER
2016
Rapid steroid hormone actions via membrane receptors
Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica Et Biophysica Acta 2016, 1863: 2289-2298. PMID: 27288742, DOI: 10.1016/j.bbamcr.2016.06.004.Peer-Reviewed Original ResearchConceptsDNA-binding sitesPhosphoinositide-3 kinaseClassical steroid hormone receptorsMembrane-bound receptorsNumber of pathwaysDevelopmental functionsGene transcriptionSteroid hormone actionSteroid hormonesImpact tumorigenesisCell cycleCellular activitiesMembrane receptorsPhospholipase DSteroid hormone receptorsPhospholipase CReceptor counterpartsRapid steroidCancer cellsNovel receptorPathwayDihydroxy vitamin D3Cytosolic receptorHormone actionHormone receptors
2015
Combined approach sialendoscopy for management of submandibular gland sialolithiasis
Schwartz N, Hazkani I, Goshen S. Combined approach sialendoscopy for management of submandibular gland sialolithiasis. American Journal Of Otolaryngology 2015, 36: 632-635. PMID: 26052045, DOI: 10.1016/j.amjoto.2015.04.001.Peer-Reviewed Original ResearchConceptsSubmandibular glandGland preservation ratePost-operative courseSuccess rateSalivary gland diseaseSubmandibular gland sialolithiasisTreatment of sialolithiasisSteroid irrigationLow morbidityIntraoperative findingsInstitution experienceRetrospective studyLocal anesthesiaSignificant complicationsHigh success rateClinical dataObstructive sialadenitisStone removalGland diseaseInvasive techniquesPreservation rateIntraoral incisionSialendoscopySialolithiasisGland
2013
Role of ERα36 in membrane-associated signaling by estrogen
Chaudhri RA, Schwartz N, Elbaradie K, Schwartz Z, Boyan BD. Role of ERα36 in membrane-associated signaling by estrogen. Steroids 2013, 81: 74-80. PMID: 24252378, DOI: 10.1016/j.steroids.2013.10.020.Peer-Reviewed Original ResearchConceptsCell typesPlasma membraneAlternative splicing variantsRole of ERα36Non-genomic responsesDifferent cell typesMembrane-associated receptorsCancer cell typesPhosphorylation cascadeTranscription factorsProtein kinaseCellular developmentGene transcriptionApoptotic signalingSplicing variantsCellular responsesNon-classical receptorsNon-classical mechanismNuclear receptorsSimilar pathwaysCell proliferationSteroid hormonesNormal cellsEstrogen receptor αTraditional receptors17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36
Schwartz N, Chaudhri RA, Hadadi A, Schwartz Z, Boyan BD. 17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36. Discover Oncology 2013, 5: 22-32. PMID: 24081562, PMCID: PMC3947116, DOI: 10.1007/s12672-013-0161-y.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisCarcinogenesisCarcinomaCell ProliferationCell SurvivalDrug Resistance, NeoplasmEstradiolEstrogen Receptor alphaFemaleHeLa CellsHumansLaryngeal NeoplasmsLymphatic MetastasisMaleMembrane ProteinsMiddle AgedMolecular Targeted TherapyNeoplasm StagingNeovascularization, PathologicPhospholipase DProtein IsoformsProtein Kinase CVascular Endothelial Growth Factor AConceptsLaryngeal cancerMembrane associated estrogen receptorsLymph node metastasisRole of E2Estrogen receptor alphaLaryngeal carcinoma cell lineSecondary sex organsChemotherapy-induced apoptosisAntiestrogen therapyNode metastasisCarcinoma cell linesLaryngeal tumorsEstrogen receptorReceptor alphaERα36Metastatic factorsSimilar associationCompelling evidenceCytoplasmic receptorsCancerTumor samplesAntiapoptotic effectNovel drugsClinical analysisE2 responsivenessSize discrepancy between sonographic and pathological evaluation of solitary papillary thyroid carcinoma
Bachar G, Buda I, Cohen M, Hadar T, Hilly O, Schwartz N, Shpitzer T, Segal K. Size discrepancy between sonographic and pathological evaluation of solitary papillary thyroid carcinoma. European Journal Of Radiology 2013, 82: 1899-1903. PMID: 23948454, DOI: 10.1016/j.ejrad.2013.07.002.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaThyroid carcinomaThyroid nodulesSonographic sizesLarge thyroid tumorsSolitary papillary thyroid carcinomaExtent of surgeryRabin Medical CenterTreatment of patientsSuspicious thyroid lesionsActual tumor sizePotential clinical implicationsHistological diameterPathological diameterPreoperative SonographicFinal pathologyPathological evaluationThyroid surgeryTumor sizeUltrasound findingsNeedle biopsyHistological examinationMedical CenterPapillary carcinomaStudy populationThyroid Surgery in the Elderly
Schwartz N, Shpitzer T, Feinmesser R, Robenshtok E, Bachar G. Thyroid Surgery in the Elderly. Gerontology 2013, 59: 401-407. PMID: 23988591, DOI: 10.1159/000351197.Peer-Reviewed Original ResearchConceptsOlder patientsThyroid diseaseIndividual risk-benefit analysisOlder groupPrevalence of comorbiditiesRetrospective cohort studyExtent of surgeryTertiary medical centerAdvanced disease stageBetween-group differencesRisk-benefit analysisBasis of ageMore comorbiditiesAdvanced diseasePostoperative complicationsTotal thyroidectomyCohort studyElderly patientsYounger patientsMedical chartsDistant metastasisHistologic subtypeSurgical managementOperative managementRecurrence rate
2012
Correlation between Eosinophil Count and Methacholine Challenge Test in Asymptomatic Subjects
Schwartz N, Grossman A, Levy Y, Schwarz Y. Correlation between Eosinophil Count and Methacholine Challenge Test in Asymptomatic Subjects. Journal Of Asthma 2012, 49: 336-341. PMID: 22715867, DOI: 10.3109/02770903.2012.672613.Peer-Reviewed Original ResearchConceptsMethacholine challenge testNegative methacholine testMethacholine testAirway hyperresponsivenessEosinophil countAsymptomatic subjectsChallenge testSeverity of AHRPositive methacholine challenge testTotal white blood cellsPositive methacholine testPeripheral blood eosinophiliaDiagnosis of asthmaAbsolute eosinophil countTotal eosinophil countFirst-degree relativesWhite blood cellsAsthmatic activityBlood eosinophiliaAbnormal spirometryNeutrophil countMethacholine concentrationPeripheral bloodMedical CenterBlood cells
2007
Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: studies on sera from women with SLE/PAPS
Schwartz N, Shoenfeld Y, Barzilai O, Cervera R, Font J, Blank M, Yacobi S, Patlas N, Cohen A, Mevorach D, Ornoy A. Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: studies on sera from women with SLE/PAPS. Lupus 2007, 16: 110-120. PMID: 17402367, DOI: 10.1177/0961203306075741.Peer-Reviewed Original ResearchConceptsPrimary anti-phospholipid syndromeAnti-phospholipid antibodiesRecurrent pregnancy lossSystemic lupus erythematosusPlacental damagePregnancy lossBetahCG levelsPlacental growthAnti-phospholipid syndromeHuman placental explantsAnti-La antibodiesDifferent antibodiesAnti-RoAntiphospholipid antibodiesThromboembolic eventsLupus erythematosusAutoimmune diseasesPlacental explantsPredictive markerProgesterone secretionHCG secretionSensitive markerHigh titersTrophoblastic apoptosisAntibodies