Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: studies on sera from women with SLE/PAPS
Schwartz N, Shoenfeld Y, Barzilai O, Cervera R, Font J, Blank M, Yacobi S, Patlas N, Cohen A, Mevorach D, Ornoy A. Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: studies on sera from women with SLE/PAPS. Lupus 2007, 16: 110-120. PMID: 17402367, DOI: 10.1177/0961203306075741.Peer-Reviewed Original ResearchConceptsPrimary anti-phospholipid syndromeAnti-phospholipid antibodiesRecurrent pregnancy lossSystemic lupus erythematosusPlacental damagePregnancy lossBetahCG levelsPlacental growthAnti-phospholipid syndromeHuman placental explantsAnti-La antibodiesDifferent antibodiesAnti-RoAntiphospholipid antibodiesThromboembolic eventsLupus erythematosusAutoimmune diseasesPlacental explantsPredictive markerProgesterone secretionHCG secretionSensitive markerHigh titersTrophoblastic apoptosisAntibodies