Featured Publications
Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury
Misra S, Khan E, Lam T, Mazumder R, Gururangan K, Hickman L, Goswami V, Funaro M, Eldem E, Sansing L, Sico J, Quinn T, Liebeskind D, Montaner J, Kwan P, Mishra N. Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury. Neurology 2023, 101: e2243-e2256. PMID: 37550071, PMCID: PMC10727219, DOI: 10.1212/wnl.0000000000207749.Peer-Reviewed Original ResearchConceptsStandardized mean differencePoststroke epilepsyBrain injuryGenetic susceptibilityDisparate time pointsRisk of epileptogenesisLate-onset seizuresDevelopment of epilepsyBlood glucose levelsTraumatic brain injuryMean biomarker levelsIndividual genetic susceptibilityWeb of ScienceReported biomarkersPrimary outcomeEpileptogenic processBiofluid biomarkersBias assessmentBiomarker levelsCommon biological pathwaysEnrichment analysisGlucose levelsHigh riskPrognostic studiesEpilepsy
2024
Prognostic biomarkers of intracerebral hemorrhage identified using targeted proteomics and machine learning algorithms
Misra S, Kawamura Y, Singh P, Sengupta S, Nath M, Rahman Z, Kumar P, Kumar A, Aggarwal P, Srivastava A, Pandit A, Mohania D, Prasad K, Mishra N, Vibha D. Prognostic biomarkers of intracerebral hemorrhage identified using targeted proteomics and machine learning algorithms. PLOS ONE 2024, 19: e0296616. PMID: 38829877, PMCID: PMC11146689, DOI: 10.1371/journal.pone.0296616.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhagePoor outcomePrognostic biomarker of ICHBiomarker of intracerebral hemorrhageHazard ratioOdds ratioShort-term poor outcomePrognostic of patient outcomeMMP-2Multivariate Cox regression modelICH prognosisInternal validation of prediction modelsModified Rankin Scale scoreIntracerebral hemorrhage patientsRankin Scale scoreUCH-L1Confidence intervalsCox regression modelsMultivariate logistic regressionProtein biomarkersIGFBP-3Regression modelsPrognostic outcomesSerum biomarkersClinical variables