Featured Publications
Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review
Misra S, Quinn T, Falcone G, Sharma V, de Havenon A, Zhao Y, Eldem E, French J, Yasuda C, Dawson J, Liebeskind D, Kwan P, Mishra N. Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review. European Journal Of Neurology 2023, 30: 1791-1800. PMID: 36912749, DOI: 10.1111/ene.15777.Peer-Reviewed Original ResearchConceptsPost-traumatic epilepsyPost-stroke epilepsyTraumatic brain injuryRisk of epilepsySystematic reviewSingle nucleotide polymorphismsBrain injuryOdds ratioRisk of PSERisk of PTEAcute brain injuryGenetic polymorphismsConfidence intervalsAssociation of SNPsQ-Genie toolPSE patientsLate seizuresHazard ratioStroke patientsTBI patientsPrespecified protocolStudy qualityCurrent evidenceEpilepsyPatients
2024
Prognostic biomarkers of intracerebral hemorrhage identified using targeted proteomics and machine learning algorithms
Misra S, Kawamura Y, Singh P, Sengupta S, Nath M, Rahman Z, Kumar P, Kumar A, Aggarwal P, Srivastava A, Pandit A, Mohania D, Prasad K, Mishra N, Vibha D. Prognostic biomarkers of intracerebral hemorrhage identified using targeted proteomics and machine learning algorithms. PLOS ONE 2024, 19: e0296616. PMID: 38829877, PMCID: PMC11146689, DOI: 10.1371/journal.pone.0296616.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhagePoor outcomePrognostic biomarker of ICHBiomarker of intracerebral hemorrhageHazard ratioOdds ratioShort-term poor outcomePrognostic of patient outcomeMMP-2Multivariate Cox regression modelICH prognosisInternal validation of prediction modelsModified Rankin Scale scoreIntracerebral hemorrhage patientsRankin Scale scoreUCH-L1Confidence intervalsCox regression modelsMultivariate logistic regressionProtein biomarkersIGFBP-3Regression modelsPrognostic outcomesSerum biomarkersClinical variables