2016
The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model
Yuksel M, Xiao X, Tai N, Vijay M, Gülden E, Beland K, Lapierre P, Alvarez F, Hu Z, Colle I, Ma Y, Wen L. The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model. Clinical & Experimental Immunology 2016, 186: 164-176. PMID: 27414259, PMCID: PMC5054566, DOI: 10.1111/cei.12843.Peer-Reviewed Original ResearchMeSH KeywordsAmmonia-LyasesAnimalsAntigen-Presenting CellsAutoantibodiesAutoantigensCD8-Positive T-LymphocytesCytochrome P-450 CYP2D6CytokinesDisease Models, AnimalGlutamate FormimidoyltransferaseHepatitis, AutoimmuneHLA-DR4 AntigenHumansHypergammaglobulinemiaImmunizationImmunoglobulin GInflammation MediatorsMiceMice, Inbred NODMice, TransgenicMultienzyme ComplexesMultifunctional EnzymesPlasma CellsT-Lymphocyte SubsetsConceptsDevelopment of AIHAutoimmune hepatitisHLA-DR4DR4 miceT cellsAnti-liver kidney microsomal type 1Anti-liver cytosol type 1Induction of AIHWild-type NOD miceNon-obese diabetic (NOD) miceType 1Key immune cell subsetsAnti-smooth muscle actinAdult autoimmune hepatitisHepatitis mouse modelElevated alanine aminotransferasePD-1 expressionPlasma cell infiltrationChronic liver diseaseRegulatory T cellsMild liver injuryImmune cell subsetsPersistent liver damageAntigen-presenting cellsHuman leucocyte antigen
2015
Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs
Hu Y, Peng J, Tai N, Hu C, Zhang X, Wong FS, Wen L. Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs. The Journal Of Immunology 2015, 195: 4176-4184. PMID: 26401004, PMCID: PMC4765177, DOI: 10.4049/jimmunol.1500884.Peer-Reviewed Original ResearchConceptsNOD miceTolerogenic APCsDiabetes developmentT cell-mediated autoimmune diseaseDiabetogenic CD8 T cellsCell-mediated autoimmune diseasePolymyxin BCD8 T cellsNonobese diabetic (NOD) miceType 1 diabetesHost immune systemIslet β-cellsAutoimmune diabetesDifferent time pointsImmune toleranceDiabetic miceAutoimmune diseasesProfound protectionT cellsImmune responseProtective effectCommensal microbiotaGut microbiotaSusceptible individualsCommensal bacteria